Skip to main content

The Development of the Tumour Vascular System: 2-D and 3-D Approaches to Network Formation in Human Xenografted Tumours

  • Chapter
Angiogenesis in Health and Disease

Part of the book series: NATO ASI Series ((NSSA,volume 227))

Abstract

Angiogenesis plays a significant role during normal growth and pathological conditions such as inflammation, wound healing and tumour growth. However, our knowledge of angiogenesis is not so extensive as justified by the significance of this research front. Thus, for example, the “International Symposium on Angiogenesis” 1991 in St. Gallen as well as the meeting “Angiogenesis in Health and Disease” of the NATO Advanced Study Institute 1991 in Porto Hydra (Greece), where the latest experimental results were presented and the current interdisciplinary research on angiogenesis was summarised, showed that basic questions still remain unresolved despite extensive and detailed knowledge in various fields.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. J. Denekamp, Vascular endothelium as the vulnerable element in tumors, Acta Radiol. Oncol., 23:217–225 (1984).

    CAS  Google Scholar 

  2. J. Folkman, Anti-angiogenesis: new concept for therapy of solid tumors Ann. Surg. 175:409–416 (1972).

    Article  PubMed  CAS  Google Scholar 

  3. J. Folkman, R. Langer, R.J. Linhardt, C. Haudenschild, S. Taylor, Angiogenesis inhibi tion and tumor regression caused by heparin or a heparin fragment in the presence of cortisone, Sience 221:719–725 (1983).

    Article  CAS  Google Scholar 

  4. J. Denekamp, B. Hobson, Endothelial cell proliferation in experimental tumours, Br. J. Cancer 46:711–720 (1982).

    Article  PubMed  CAS  Google Scholar 

  5. N. Paweletz, M. Knierim,Tumor-related angiogenesisCrit. Rev. Oncol. Hematol. 9:197–242 (1989).

    Article  PubMed  CAS  Google Scholar 

  6. R. Thoma, Untersuchungen über die Histogenese und Histomechanik des Gefäß-Systems, Stuttgart, Enke (1893).

    Google Scholar 

  7. J.G. Simpson, R.A. Fraser, Angiogenese in malignen Tumoren, in: P. Vaupel, F. Hammersen eds., Mikrozirkulation in Forschung und Klinik. vol. 2, Karger, Basel-München-ParisLondon-New York-Sydney, 1–14. (1989).

    Google Scholar 

  8. F. Hammersen, U. Osterkamp-Baust, B. Endlich, Ein Beitrag zum Feinbau terminaler Strombahnen und ihrer Entstehung in bösartigen Tumoren, in: P. Vaupel, F. Hammersen eds., Mikrozirkulation in Forschung und Klinik, vol. 2, Karger, Basel-Mönchen-ParisLondon-New York-Tokyo-Sydney, 15–51 (1989).

    Google Scholar 

  9. R.K. Jain, Determinants of tumor blood flow: a review, Cancer Res. 48:2641–2658 (1988).

    PubMed  CAS  Google Scholar 

  10. V. Budach, M. Bamberg, K. Donhuijsen, U. Schmidt, D. van Beuningen, M. Stuschke, Serial xenotransplantation of a human embryonal carcinoma in experimental urology, J. Urol.,136:1143–1147 (1986).

    PubMed  CAS  Google Scholar 

  11. M.A. Konerding, F. Steinberg, C. Streffer, The vasculature of xenotransplanted human melanomas and sarcomas. 1. Vascular corrosion casting studies, Acta Anat. 136:21–26 (1989).

    Article  PubMed  CAS  Google Scholar 

  12. M.A. Konerding, F. Steinberg, C. Streffer, The vasculature of xenotransplanted melanomas and sarcomas. 2. Scanning and transmission electron microscopic studies, Acta Anat. 136:27–33 (1989).

    Article  PubMed  CAS  Google Scholar 

  13. M.A. Konerding, F. Steinberg, V. Budach, The vascular system of xenotransplanted tumors - scanning and light microscopic studies, Scanning Microsc. 3:327–336 (1989).

    PubMed  CAS  Google Scholar 

  14. H.A. Eddy, G.W. Casarett, Development of the vascular system in the hamster malignant neurilemmoma, Microvasc Res. 6:63–82 (1973).

    Article  PubMed  CAS  Google Scholar 

  15. T.W. Grunt, A. Lametschwandtner, K. Kaper, The angioarchitecture of the Lewis lung carcinoma in laboratory mice, Scanning Microsc. II:557–573 (1986).

    Google Scholar 

  16. B.A. Warren, The ultrastructure of the microcirculation at the advancing edge of Walker 256 carcinoma, Microvasc. Res. 2:443–453 (1970).

    CAS  Google Scholar 

  17. K. Donhuijsen, D. van Beuningen, V. Budach, U. Schmidt, Instability of xenotransplanted soft tissue sarcomas: morphologic and flow cytometric results, Cancer 61:68–75 (1988).

    Article  PubMed  CAS  Google Scholar 

  18. F. Steinberg, M.A. Konerding, C. Streffer, The vascular architecture of human xenotransplanted tumors: histological, morphometrical and ultrastructural studies, Int. J. Cancer Res., 116:517–524 (1991).

    Google Scholar 

  19. M.A. Konerding, F. Steinberg, U. Winkler, C. Streffer, Comparison of human primary and xenotransplanted tumours: the tumour vascular system as revealed by transmission and scanning electron microscopy, J. Cancer Res. Clin. Oncol. 116:514 (1990).

    Google Scholar 

  20. B.C. Giovanella, J. Fogh, Present and future trends in investigations with the nude mouse as a recipient of human tumor transplants, J. Fogh, B.C. Giovanella, eds., The Nude Mouse in Experimental and Clinical Research, Academic Press, New York, 281–297 (1978).

    Google Scholar 

  21. A. Bugajski, M. Nowogrodzka-Zagorska, J. Lenko, A.J. Miodonski, Angiomorphology of the humen renal clear cell carcinoma. A light and scanning electron microscopic study, Virchows Arch. (A) 415:103–113 (1989).

    Article  CAS  Google Scholar 

  22. F. Steinberg, M.A. Konerding, A. Sander, C. Streffer, Vascularization, proliferation and necrosis in untreated human primary tumours and untreated human xenografts, Int. J. Radiat. Biol. 60:161–168 (1991).

    Article  PubMed  CAS  Google Scholar 

  23. J. Folkman, C. Haudenschild, Angiogenesis in vitro, Nature 288:551–556 (1980).

    Article  PubMed  CAS  Google Scholar 

  24. P. Vaupel, H.P. Fortmeyer, S. Runkel, Blood flow, oxygen consumption, and tissue oxygenation of human breast cancer xenografts in nude rats, Cancer Res. 47:3496–3503 (1987).

    PubMed  CAS  Google Scholar 

  25. M. Lehmann, M.A. Konerding, M. Blank, Vascularisation of the peripheral nerve after epineural suture, in: M. Samii, Peripheral Nerve Lesions, Springer, Berlin-HeidelbergNew York-London-Paris-Tokyo-Hongkong-Barcelona, 149–153 (1990)

    Chapter  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer Science+Business Media New York

About this chapter

Cite this chapter

Konerding, M.A., van Ackern, C., Steinberg, F., Streffer, C. (1992). The Development of the Tumour Vascular System: 2-D and 3-D Approaches to Network Formation in Human Xenografted Tumours. In: Maragoudakis, M.E., Gullino, P., Lelkes, P.I. (eds) Angiogenesis in Health and Disease. NATO ASI Series, vol 227. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3358-0_16

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-3358-0_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6481-8

  • Online ISBN: 978-1-4615-3358-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics