Abstract
The first step in the formation of blood vessels is the emergence of their inner lining cells, the endothelial cells (EC). These cells then associate into tubular structures and other cells types, notably smooth muscle cells or pericytes, organize themselves around them to make the vessel wall. Structural specializations such as tight junctions in vessels of the blood-brain barrier or regionalized. adhesion molecules are acquired by differentiating EC. The development of new blood vessels is an uncommon physiological event in adults. It occurs during development of the corpus luteum or the placenta, during wound healing and regeneration or during tumorigenesis. The latter phenomenon has been elected by many groups for detailed morphological and biochemical analysis. Various in vivo and in vitro models have been devised to study this process. It could be shown that endothelial cells do not arise de novo in the adult but derive from already established blood vessels. The basement membrane surrounding the capillaries breaks down; endothelial cells undergo mitogenesis and migrate into the tumor under the effect of chemoattractive and mitogenic factors (review in Folkman, 1985). This process has been designated as angiogenesis and several growth factors have been identified with angiogenic properties. The quiescent state normal in most physiological situations is maintained through an interplay between endothelial cells and pericytes (Sato et al., 1990).
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Beaupain, D., Martin, C. and Dieterlen-Lièvre, F., 1979, Are developmental hemoglobin changes related to the origin of stem cells and site of erythropoiesis ? Blood, 53: 212.
Chen, C.H., Bucy, R.P. and Cooper, M.D., 1991, T cell differentiation in birds, Sem. Immunol.
Coffin, J.D. and Poole, T.J., 1988, Embryonic vascular development: immunohistochemical identification of the origin and subsequent morphogenesis of the major vessel primordia in quail embryos, Development, 102: 735.
Dieterlen-Lièvre, F., 1984, Emergence of intraembryonic blood stem cells studied in avian chimeras by means of monoclonal antibodies, Dev. Comp. Immunol., supplt.3: 75.
Dieterlen-Lièvre, F. and Le Douarin, N.M., 1991, The use of avian chimeras in developmental biology, In: “Avian Immunology, Basis and Practice”, A. and P. Toivanen eds, CRC Press, sous presse.
Dieterlen-Lièvre, F. and Martin, C., 1981, Diffuse intraembryonic hemopoiesis in normal and chimeric avian development, Dev. Biol., 88: 180.
Folkman, J., 1985, Toward an understanding of angiogenesis: search and discovery, Perspectives in Biology and Medicine, 29: 10.
Hirakow, R. and Hiruma, T., 1981, Scanning electron microscopy study on the development of primitve blood vessels in chick embryos at the early somite-stage, Anat. Embryol., 163: 299.
Houssaint, E., Tobin, E., Cihak, J. and Lösch, U., 1987, A chicken leukocyte common antigen: biochemical characterization and ontogenetic study, Eur. J. Immunol., 17: 287.
Jotereau, F. and Le Douarin, N.M., 1978, The developmental relationship between osteocytes and osteoclasts: a study using the quail-chick nuclear marker in endochondral ossification, Dev. Biol,. 63: 253.
Kessel, J. and Fabian, B., 1987, Inhibitory and stimulatory influences on mesodermal erythropoiesis in the early chick blastoderm, Development, 101: 45.
Labastie, M.C., Poole, T.J., Péault, B.M. and Le Douarin, N.M., 1986, MB1, a quail leukocyte-endothelium antigen: partial characterization of the cell surface and secreted forms in cultured endothelial cells. Proc. Natl. Acad. Sci. USA, 83: 9016.
Labastie, M.C., 1989, MB1, a quail leukocyte-endothelium antigen: further characterization of soluble and cell-associated forms. Cell Diff. and Dev., 27: 151.
Le Douarin, N.M., 1973, A biological cell labeling technique and its use in experimental embryology, Dev. Biol., 30: 217.
Le Lièvre, C. and Le Douarin, N., 1975, Mesenchymal derivatives of the neural crest: analysis of chimaeric quail and chick embryos, J. Embryol. exp. Morphol., 34: 125.
Martin, C., Beaupain, D. and Dieterlen-Lièvre, F., 1980, A study of development of the hemopoietic system using Quail-Chick chimeras obtained by blastoderm recombination, Dev. Biol., 75: 303.
Mucenski, M.L., McLain, K., Kier, A.B., Swerdlow, S.H., Schreiner, C.M., Miller, T.A., Pietryga, D.W., Scott, W.J. and Potter, S.S., 1991, A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis, Cell, 65: 677.
Noden, D.M., 1989, Embryonic origins and assembly of blood vessels, Am. Rev. Resp. Dis., 140: 1097.
Pardanaud, L., Altmann, C., Kitos, P., Dieterlen-Lièvre, F. and Buck, C.A., 1987, Vasculogenesis in the early quail blastodisc as studied with a monoclonal antibody recognizing endothelial cells, Development, 100: 339.
Pardanaud L., Yassine F. and Dieterlen-Lièvre F., 1989, Relationship between vasculogenesis, angiogenesis and hemopoiesis during avian ontogeny, Development. 105, 473.
Péault, B., Thiery, J.P., and Le Douarin, N.M., 1983, Surface marker for the hemopoietic and endothelial cell lineages in the quail that is defined by a monoclonal antibody, Proc. Natl. Acad. Sci. USA, 80: 2976.
Péault, B., 1987, MB1, a quail leukocyte/vascular endothelium antigen: characterization of the lymphocyte-surface form and identification of its secreted counterpart as alpha2-microglobulin, Cell Differentiation, 21: 175.
Péault, B., Coltey, M. and Le Douarin, N.M., 1988, Ontogenic emergence of a quail leukocyte/endothelium cell surface. Cell Differentiation, 23: 165.
Risau, W. and Lemmon, V., 1988, Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesis, Dev. Biol., 125: 441.
Sabin, F.R., 1920, “Studies on the origin of the blood-vessels and of red-blood corpuscles as seen in the living blastoderm of chicks during the second day of incubation,” In: Contributions to Embryology, vol.9, Carnegie Inst. Wash., pp.214–262.
Sariola, H., Péault, B., Le Douarin, N.M., Buck, C., Dieterlen-Lièvre, F. and Saxen, L., 1984, Extracellular matrix and capillary ingrowth in interspecies chimeric kidneys, Cell Differentiation, 15: 43.
Sato, Y., Tsuboi, R., Lyons, R., Moses, H. and Rifkin, D.B., 1990, Characterization of the activation of latent TGF-b by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulation system, J. Cell Biol., 111: 757.
Schramm, C. and Solursh, M., 1990, The formation of premuscle masses during chick wing bud development. Anat. Embryol., 182: 235.
Stern, C.D., Fraser, S.E., Keynes, R.J. and Primmett, D.R.N., 1988, A cell lineage analysis of segmentation in the chick embryo, Development, 104: supplt., 231.
Stewart, P.A. and Wiley, M.J., 1981, Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cellls: a study using quail-chick transplantation chimeras, Dev. Biol., 84, 183.
Vandenbunder, B., Pardanaud, L., Jaffredo, T., Mirabel, M.A. and Stéhelin, D., 1989, Complementary patterns of expression of c-etsl, cmyb and c-myc in the blood-forming system of the chick embryo, Development, 106: 265.
Williams, R.L., Risau, W., Zerwes, H.G., Drexler, H., Aguzzi, A. and Wagner, E.F., 1989, Endothelioma cells expressing the polyoma middle T oncogene induce hemangiomas by host cell recruitment, Cell, 57: 1053.
Wilt, F.H., 1965, Erythropoiesis in the chick embryo: the role of endoderm. Science, 147, 1588.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Dieterlen-Lièvre, F., Pardanaud, L. (1992). Embryonic Development of Blood Vessels. In: Maragoudakis, M.E., Gullino, P., Lelkes, P.I. (eds) Angiogenesis in Health and Disease. NATO ASI Series, vol 227. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3358-0_1
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3358-0_1
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6481-8
Online ISBN: 978-1-4615-3358-0
eBook Packages: Springer Book Archive