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HIV Perinatal Transmission and Reproductive Health

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AIDS and Women’s Reproductive Health

Part of the book series: Reproductive Biology ((RBIO))

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Abstract

HIV-1 infection in risk groups such as intravenous drug abusers, their sexual partners, and sexually active women in many developing countries has resulted in an increased number of HIV-infected women of childbearing age. In most parts of the world, where blood bank screening for HIV-1 is now in effect, mother-to-child transmission of the virus will be the major mode of infection to infants. Several prospective studies of infants born to infected mothers have shown a perinatal transmission rate of approximately 25–40% in both developed and developing countries (1–5). The actual mechanisms of mother-infant transmission are not yet known; data is supportive of trans-placental spread (6–8), birth canal transmission at delivery (9), and breast feeding (1, 10).

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References

  1. Blanche S, Rouzioux C, Guihard Moscato, ML et al. A Prospective Study of Infants Born to Women Seropositive for Human Immunodeficiency Virus Type 1. New Engl J Med 1989; 320:1648.

    Article  Google Scholar 

  2. The European Collaborative Study. Mother-To-Child Transmission of HIV Infection. Lancet 1988; 2:1039–43.

    Article  Google Scholar 

  3. Andiman WA, Simpson J, Dember L et al. Prospective Cohort of 50 Infants Born to HIV Seropositive Mothers. IV International Conference on AIDS, Stockholm, Sweden, June 1988.

    Google Scholar 

  4. Italian Multicentre Study. Epidemiology, Clinical Features, and Prognostic Factors of Paediatric HIV Infection. Lancet 1988; ii: 1043–1045.

    Google Scholar 

  5. Ryder RW, Nsa W, Hassig SE, Behets F, Rayfield M, Ekungola B et al. Perinatal Transmission of the Human Immunodeficiency Virus Type 1 to Infants of Seropositive Women in Zaire. New Engl J Med 1989; 320:1637–1642.

    Article  PubMed  CAS  Google Scholar 

  6. Sprecher S, Soumenkoff G, Puissant F, Degueldre M. Vertical Transmission of HIV in 15-Week Fetus. Lancet 1986; 2:288.

    Article  PubMed  CAS  Google Scholar 

  7. Marion RW, Wiznia AA, Hutcheon G, Rubinstein A. Human T-Cell Lymphotropic Virus Type III (HTLV-III) Embryopathy: A New Dysmorphic Syndrome Associated with Intrauterine HTLV-III Infection. Am J Dis Child 1986; 140:638–640.

    PubMed  CAS  Google Scholar 

  8. Qazi AH, Sheikh TM, Fikrig S, Menikoff H. Lack of evidence for craniofacial dysmorphism in perinatal human immunodeficiency virus infection. JPediatr 1988; 112:7–11.

    Article  CAS  Google Scholar 

  9. Wofsy CB, Cohen JB, Hauer LB et al. Isolation of AIDS-associated retrovirus from genital secretions of women with antibodies to the virus. Lancet 1986; i:527–529.

    Article  Google Scholar 

  10. Thiry L, Sprecher-Goldberger S, Jonckheer T et al. Isolation of AIDS c=virus from cell-free breast milk of three healthy virus carriers. Lancet 1985; ii:891–892.

    Article  Google Scholar 

  11. Scott GB, Buck BE, Leterman JG et al. Acquired Immunodeficiency Syndrome in Infants. New Engl J Med 1984; 310:76–81.

    Article  PubMed  CAS  Google Scholar 

  12. Pahwa S, Kaplan M, Fikrig S et al. Spectrum of human T-cell lymphotropic virus Type III infection in children. JAMA 1986; 255:2299–2305.

    Article  PubMed  CAS  Google Scholar 

  13. Oleske J, Minnefor A, Cooper R et al. Immune deficiency syndrome in children. DAMA 1983; 249:2345–2349.

    CAS  Google Scholar 

  14. Belman AL, Ultmann MR, Horoupian D et al. Neurological complications in infants and children with acquired immune deficiency syndrome. Annals of Neuro 1985; 18:560–6.

    Article  CAS  Google Scholar 

  15. Scott GB, Hutto C, Makuch RW, Mastrucci MT, O’Connor T, Mitchell CD, Trapido EJ, Parks WR. Survival in children with perinatally acquired human immunodeficiency virus type 1 infection. New Engl J Med 1989; 321:1791–1796.

    Article  PubMed  CAS  Google Scholar 

  16. Novick BE, Rubinstein A. AIDS - The paediatric perspective. AIDS 1987; 1:3–7.

    PubMed  CAS  Google Scholar 

  17. Bernstein LJ, Rubinstein A. Acquired immunodeficiency in infants and children. Prog Allergy 1986; 37:194–206.

    PubMed  CAS  Google Scholar 

  18. Matheron S, DeMaria H, Dormont D, Rey MA, Courpotin C, Couland JP, Saimot AG, Brun-Vesinet E HIV-2 Infection in mother-infant couples. IV International Symposium on AIDS, Stockholm, Sweden, June 1988.

    Google Scholar 

  19. Andreasson P-A, Dias F, Goudiaby JMT, Naucler A, Biberfield G. HIV-2 Infection in prenatal women and vertical transmission of HIV-2 in Guinea-Bissau. IV International Conference on AIDS in Africa, Marseilles, France, October 1989.

    Google Scholar 

  20. Hojlyng N, Kvinesdal BB, Molbak K, Aaby P. Vertical Transmission of HIV-2; Does It Occur? IV International Conference on AIDS in Africa, Marseilles, France, October 1989.

    Google Scholar 

  21. Poulsen A-G, Aaby P, Frederiksen K, Kvinesdal B, Molbak K, Dias F, Lauritzen E. Prevalence of and Mortality from Human Immunodeficiency Virus Type-2 in Bissau, West Africa. Lancet 1989; i:827–830.

    Article  Google Scholar 

  22. Ouattara SA, Gody M, Rioche M et al. Blood transfusions and HIV infections (HIV1, HIV2/LAV2) in Ivory Coast. J of Tropical Medicine and Hygiene 1988; 91:212–215.

    CAS  Google Scholar 

  23. Veronesi R, Mazza C, Santos Ferreira MO, Lourenco MH. HIV-2 in Brazil. Lancet 1987; ii:402 (letter).

    Article  Google Scholar 

  24. Gnaore E, De Cock KM, Gayle H et al. Prevalence and Mortality from HIV Type 2 in Guinea Bissau, West Africa. Lancet 1989; ii:513 (letter).

    Article  Google Scholar 

  25. Johnson JP, Nair P, Alexander S. Early Diagnosis of HIV Infection in the Neonate. New Engl J Med 1987; 316:273–274.

    Article  PubMed  CAS  Google Scholar 

  26. Pyun KH, Ochs HD, Dufford MTW, Wedgwood RJ. Perinatal Infection with Human Immunodeficiency Virus. Med Intellig 1987; 317:611–614.

    CAS  Google Scholar 

  27. Harnish DG, Hammerberg O, Walker IR, Rosenthal KL. Early detection of HIV infection in a newborn. New Engl J Med 1987; 316:272–271.

    Article  PubMed  CAS  Google Scholar 

  28. Borkowsky W, Paul D, Bebenroth D, Krasinski K, Moore T, Chandwani S. Humanimmunodeficiency-virus infections in infants negative for anti-HIV by enzyme-linked immunoassay. Lancet 1987 i:1168–1170.

    Article  Google Scholar 

  29. Monforte AA, Novati R, Marchisip et al. Early Diagnosis of HIV Infection in Infants. AIDS 1988; 3:391–395.

    Article  Google Scholar 

  30. Laure F, Rouzioux C, Veber F et al. Detection of HIV-1 DNA in infants and children by means of the Polymerase Chain Reaction. Lancet 1988; ii:538–541.

    Article  Google Scholar 

  31. Rogers MF, Ou CY, Rayfield M et al. Use of the Polymerase Chain reaction for early detection of the proviral sequences of human immunodeficiency virus in infants born to seropositive mothers. New Engl J Med 1989; 320:1649–1654.

    Article  PubMed  CAS  Google Scholar 

  32. Dormont D, DiMaria H, Courpotin C et al. Virology and Immunology Follow-Up of Newborns from Positive Mothers: Diagnostic and Prognostic Value of HIV Positive Cell Culture During the Neonatal Period. IV International Symposium on AIDS, Stockholm, Sweden, June 1988.

    Google Scholar 

  33. Wong-Staal F. Human Immunodeficiency Viruses and Their Replication. In: Virology, 2nd Edition, eds, Fields DM et al. Raven Press, Ltd., 1990, pp. 1529–1540.

    Google Scholar 

  34. Essex M, Allan J, Kanki P, McLane MF, Malone G, Kitchen L, Lee TH. Antigens of Human T-Lymphotropic Virus Type III/Lymphadenopathy-Associated Virus. Ann Int Med 1985; 103:700–703.

    PubMed  CAS  Google Scholar 

  35. Lee TH, Coligan JE, Allan JS, McLane MF, Groopman JE, Essex M. A New HTLVIII/LAV Protein Encoded by a Gene Found in Cytopathic Retroviruses. Science 1986; 231:1546–1549.

    Article  PubMed  CAS  Google Scholar 

  36. Allan JS, Coligan JE, Lee TH, McLane MF, Kanki PJ, Groopman JE, Essex M. A New HTLV III/LAV Encoded Antigen Detected by Antibodies from AIDS Patients. Science 1985; 230:810–813.

    Article  PubMed  CAS  Google Scholar 

  37. Arya SK, Gallo RC. Three Novel Genes of Human T-Lymphotropic Virus Type III: Immune Reactivity of Their Products with Sera from Acquired Immune Deficiency Syndrome Patients. Proc Natl Acad Sci 1986; 83:2209–2213.

    Article  PubMed  CAS  Google Scholar 

  38. Franchini G, Robert-Guroff M, Aldovini A et al. Spectrum of Natural Antibodies Against Five HTLV-III Antigens in Infected Individuals: Correlation of Antibody Prevalence with Clinical Status. Blood 1987; 69:437–441.

    PubMed  CAS  Google Scholar 

  39. Matsuda Z, Chou MJ, Matsuda M, Huang JH, Chen YM, Redfield R, Mayer K, Essex M, Lee TH. Human Immunodeficiency Virus Type 1 has an additional coding sequence in the central region of the genome. Proc Natl Acad Sci 1988; 85:6968–6972 (1988).

    Article  PubMed  CAS  Google Scholar 

  40. Yu XF, Ito S, Essex M, Lee TH. A Naturally Immunogenic Virion-Associated Protein Specific for HIV-2 and SIV. Nature 1988; 335:262–265.

    Article  PubMed  CAS  Google Scholar 

  41. Guyader M, Emerman M, Sonigo P, Clavel F, Montagnier L, Alizon M. Genome Organization and Transactivation of the Human Immunodeficiency Virus Type 2. Nature 1987; 326:662–669.

    Article  PubMed  CAS  Google Scholar 

  42. Essex M, Kanki PJ, Barin F, Chou MJ, Lee TH. Immunogenicity of HIV-1 and HIV-2 Antigens and Their Relationship to Disease Development. 2nd Colloque des Cent Gardes 1987, ed. Girard M and Vallette L, 1988, pp. 219–220.

    Google Scholar 

  43. Allan JS, Essex M. Unpublished data.

    Google Scholar 

  44. Bann F, McLane MF, Allan JS, Lee TH, Groopman J, Essex M. Virus Envelope Protein of Human T cell Leukemia Virus Type III (HTLV III) Represents Major Target Antigen for Antibodies in AIDS Patients. Science 1985; 228:1094–1096.

    Article  Google Scholar 

  45. Allan J, Coligan JE, Bann F, McLane MF, Rosen C, Sodroski J, Haseltine WA, Lee TH, Essex M. Major Glycoprotein Antigens that Induce Antibodies in AIDS Patients are Encoded by HTLV III. Science 1985; 228:1091–1094.

    Article  PubMed  CAS  Google Scholar 

  46. Bann F, M’Boup S, Denis F, Kanki P, Allan JS, Lee TH, Essex M. Serological Evidence for a Virus Related to Simian T-Lymphotropic Retrovirus III in Residents of West Africa. Lancet 19485; ii:1387–1390.

    Google Scholar 

  47. Lee TH, Redfield RF, Chou MJ, Huang TH, Saah A, Hsieh CC, Yu XF, McLane MF, Mar-link R, Burke DS, Essex M. Association Between Antibody to Envelope Glycoprotein gp120 and the Outcome of HIV Infection. In: Vaccines 1988: New Chemical and Genetic Approaches to Vaccination, eds. Ginsberg H et al. Cold Spring Harbor Press,1988,pp.373–377.

    Google Scholar 

  48. Lee TH, Syu WJ, Chou MJ, Essex M. Immunodominant Epitopes of HIV-1 gp120: A Possible Obstacle for Vaccine Development. In: Vaccines 89 Modern Approaches to New Vaccines Including Prevention of AIDS,eds. Lerner RA, Ginsberg H, Chanock RM

    Google Scholar 

  49. Goedert JJ, Drummond JE, Minkoff HL, Stevens R, Blattner WA, Mendez H, RobertGuroff M, Holman S, Rubinstein A, Willoughby A, Landeman SH. Mother-to-Infant Transmission of Human Immundeficiency Virus Type 1: Association with Prematurity or Low Anti-gp120. Lancet 1989; ii:1351–1354.

    Article  Google Scholar 

  50. Rossi P, Moschese V, Broliden PA, Fundaro C, Quinti I, Plebani A, Giaquinto C, Tovo PA, Ljunggren K, Rosen J, Wigzell H, Jondal M, Wahren B. Presence of maternal antibodies to human immunodeficiency virus type 1 envelope glocoprotein gp epitopes correlates with the uninfected status of children to seropositive mothers. Medical Sciences 1989; 86:8055–8058.

    CAS  Google Scholar 

  51. Kanki P, Ricard D, M’Boup S, Essex M. Perinatal Transmission of HIV-2. IV International Conference on AIDS, Stockholm, Sweden, June 1988.

    Google Scholar 

  52. Ryder RW and Hassig SE. The epidemiology of perinatal transmission of HIV. AIDS 2 (suppl) 1988; S83–S89.

    Google Scholar 

  53. Nelson AM, Anderson V, Ryder R et al. Placental pathology as a predictor of perinatal HIV infection in infants born to HIV seropositive women in Kinshasa, Zaire. IV International Conference on AIDS, Stockholm, Sweden, 1988. Abstract 6585.

    Google Scholar 

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© 1991 Springer Science+Business Media New York

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Kanki, P.J., Kalengayi, M., Boup, S.M. (1991). HIV Perinatal Transmission and Reproductive Health. In: Chen, L.C., Amor, J.S., Segal, S.J., Anderson, J.M. (eds) AIDS and Women’s Reproductive Health. Reproductive Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3354-2_12

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  • DOI: https://doi.org/10.1007/978-1-4615-3354-2_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6479-5

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