Aspirin as a Biological Response Modifier

Hsia, Judith; Tang, Ting

doi:10.1007/978-1-4615-3340-5_16

Aspirin as a Biological Response Modifier

Judith Hsia³ &
Ting Tang³

Chapter

52 Accesses
2 Citations

Abstract

For some time our laboratory has been interested in the development and control of cellular immunity, both by the thymosins and other agents. Thymosins are a family of peptide hormones produced by the thymus and thymus-derived tissues such as T lymphocytes, which modulate differentiation of a variety of T cells providing us with immunity against viruses, mycobacteria, fungi and tumors. About ten years ago, while studying thymosins, Dr. Allan Goldstein’s laboratory looked at cyclooxygenase inhibitors, among other agents, to determine whether they might influence or inhibit thymic peptides. These studies demonstrated that acetyl salicylic acid (aspirin) could enhance immune responses and synergize with thymosins.

This is a preview of subscription content, log in via an institution.

Chapter: USD 29.95; Price excludes VAT (USA)

eBook: USD 39.99; Price excludes VAT (USA)

Softcover Book: USD 54.99; Price excludes VAT (USA)

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

References

R.S. Rappaport and G. R. Dodge, Prostaglandin E inhibits the production of human interleukin 2, J. Exp. Med. 155:943 (1982).
Article PubMed CAS Google Scholar
S. Chouaib, L. Chatenould, D. Klatzmann, et al., The mechanisms of inhibition of human IL 2 production. II. PGE₂ induction of suppressor T lymphocytes, J Immunol. 133:1851 (1984).
Google Scholar
J.S. Goodwin and D. R. Webb, Regulation of the immune response by prostaglandins, Clin. Immunol. Immunopath. 15:106 (1980).
Article CAS Google Scholar
J. R. Vane, Inhibition of prostaglandin synthesis as a mechanism of action of aspirin-like drugs, Nature New Biol. 231:232 (1971).
PubMed CAS Google Scholar
M. M. Zatz, A. Skotnicki, J. M. Bailey, J. H. Oliver, and A. L. Goldstein, Mechanism of action of thymosin. II. Effects of aspirin and thymosin on enhancement of IL-2 production, Immunopharmacol. 9:1989 (1985).
Article Google Scholar
J. Hsia, N. Sarin, J. H. Oliver, and A. L. Goldstein, Aspirin and thymosin increase interleukin-2 and interferon-γ production by human peripheral blood lymphocytes, Immunopharmacol. 17:167 (1989).
Article CAS Google Scholar
J. Hsia, G. L. Simon, N. Higgins, A. L. Goldstein, and F. G. Hayden, Immune Modulation by Aspirin during Experimental Rhinovirus Colds, Bull. N. Y. Acad. Med. 65:47 (1989).
Google Scholar
J. Hsia and T. Tang, Augmentation of Influenza Vaccine Response by Aspirin, Clin. Res. in press.
Google Scholar

Download references

Author information

Authors and Affiliations

Department of Medicine, George Washington University, Washington, DC, USA
Judith Hsia & Ting Tang

Authors

Judith Hsia
View author publications
You can also search for this author in PubMed Google Scholar
Ting Tang
View author publications
You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

The George Washington University School of Medicine, Washington, D.C., USA
Allan L. Goldstein
University of Rome “Tor Vergata”, Rome, Italy
Enrico Garaci

Rights and permissions

Reprints and permissions

Copyright information

About this chapter

Cite this chapter

Hsia, J., Tang, T. (1992). Aspirin as a Biological Response Modifier. In: Goldstein, A.L., Garaci, E. (eds) Combination Therapies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3340-5_16

Download citation

DOI: https://doi.org/10.1007/978-1-4615-3340-5_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6472-6
Online ISBN: 978-1-4615-3340-5
eBook Packages: Springer Book Archive

Publish with us

Policies and ethics