Abstract
Acquired immune deficiency syndrome (AIDS) is a global disease which has presented extraordinary challenge to the scientific community in terms of understanding the pathogenesis, treatment and prevention of the disease. With the identification of human immunodeficiency virus (HIV) as the etiological agent (1–3), it is now possible to investigate approaches to develop treatments for the disease and vaccines for the prevention of the disease. With an estimated six to ten million HIV-1 infected individuals worldwide and over 160,000 known cases of AIDS in the United States, it is extremely important and urgent to look for strategies to control the disease by antiviral therapy.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Gallo, R.C., Sci. Amer. 256, 46–56, 1987.
Sarin, P.S., Ann. Rev. Pharmacol. 28, 411–428, 1988.
Haseltine, W.A., J. AIDS 2, 311–334, 1989.
Yarchoan, R. et al., New Engl. J. Med. 321, 726–738, 1989.
Aloia, R.C. et al., Proc. Natl. Acad. Sci. USA 85, 900–904, 1988.
Crews, F.T. et al., Drug Dev. Res. 14, 31–44, 1988.
Yarchoan, R. et al, Science 245, 412–415, 1989.
Sarin, P.S. et al., Biochem. Pharmacol. 34, 4075–4079, 1985.
Sandstrom, E.G. et al., Lancet 1, 1480–1482, 1985.
Schafner, C.P. et al., Biochem. Pharmacol. 35, 4110–4113, 1986.
Sarin, P.S. et al., New Engl. J. Med. 313, 1289–1290, 1985.
Chandra, P. and Sarin, P.S., Arznei Forsch (Drug Res) 36, 184–186, 1986.
Chandra, A. et al., J. Natl. Cancer Inst. 78, 663–666, 1987.
Sarin, P.S. et al., J. Natl. Cancer Inst. 78, 663–666, 1987.
Zamecnik, P.C. et al., Proc. Natl. Acad. Sci. USA
Goodchild, J. et al., Proc. Natl. Acad. Sci. USA 85, 5507–5511, 1988.
Agrawal, S. et al., Proc. Natl. Acad. Sci. USA 85, 7079–7083, 1988.
Sarin, P.S. et al., Proc. Natl. Acad. Sci. USA 85, 7448–7451, 1988.
Letsinger, R. L. et al., Proc. Natl. Acad. Sci. USA 86, 6553–6556, 1989.
Agrawal, S. et al., Proc. Natl. Acad. Sci. USA 86, 7790–7794, 1989.
Levine, A.M. et al., Ann. Intern. Med. 105, 32–37, 1986.
Neto, C.C. et al., Biochem. Biophys. Res. Commun. 171, 458–464, 1990.
Spectoe, S.A., Ripley, D., and Hsia, K., Antimicrob. Agents. Chemotherapy 33, 920–923, 1989.
Eriksson, B.F.H., and Schinazi, R.F., Antimicrob. Agents. Chemotherapy 33, 663–669, 1989.
Koshida, R. et al., Antimicrob. Agents. Chemotherapy 33, 778–780, 1989.
Johnson, V.A. et al., Antimicrob. Agents. Chemotherapy 33, 53–57, 1989.
Raetz, C.H.R. et al., Science 196, 303–305, 1977.
Ryn, E.K. et al., J. Med. Chem. 25, 1322–1329, 1982.
Hostetler, K.Y. et al., J. Biol. Chem. 265, 6112–6117, 1990.
Sterin, J. M. et al., Biochem. Biophys. Res. Commun. 171, 451–457, 1990.
Stephenson, M.L., and Zamecnik, P.C., Proc. Natl. Acad. Sci. USA 75, 285–289, 1978.
Zamecnik, P.C., and Stephenson, M.L., Proc. Natl. Acad. Sci. USA 75, 280–284, 1978.
Quartin, R.S., and Wetmur, J.G., Biochemistry 28, 1040–1044, 1989.
Ts’o, P.O.P., et al., Annals of New York Academy of Sciences 507, 220–229, 1987.
Matsukura, M. et al., Proc. Natl. Acad. Sci. USA 84, 7706–7710, 1987.
Zamecnik, P.C. Agrawal, S., Eds., Annual Review of AIDS Research, New York, Marcel Dekker Press, In press.
Agrawal, S., and Sarin, P.S., Eds., Advanced Drug Delivery Rev., Amsterdam, Elsevier, In press.
Agris, C.H. et al., Biochemistry 25, 2628–2632, 1986.
Lemaitre, M., Bayard, B., and LeBleu, B., Proc. Natl. Acad. Sci. USA 84, 648–653, 1987.
Miller, P.S., and Ts’o, P.O.P., Anti-Cancer Drug Design 2, 117–129, 1987.
Kabanov, A.V. et al., FEBS Lett 259, 327–331, 1990.
Leiter, J.M.E. et al., Proc. Natl. Acad. Sci. USA 87, 3430–3434, 1990.
Gewirtz, A.M., and Calabretta, B., Science 242, 1303–1306, 1988.
Heikkila, R. et al., Nature (London) 328, 445–447, 1987.
Blake, K.R., Murakani, A. and Miller, P.S., Biochemistry 24, 6132–6137, 1990.
Miroshniechenko, N.A. et al., FEBS Lett 234, 65–68, 1988.
Kawasaki, E.S., Nucleic Acids Res. 13, 4991–4997, 1985.
Cheon, C.I., Delaney, A.J. Verma, D.P.S., Plant. Sci. 66, 231–238, 1990.
Hiatt, W.R., Kramer, M. and Sheehy, R.E., Genet. Eng. 11, 49–63, 1989.
Harel-Bellan, A. et al., Colloq. Inserm. 81, 1989.
Traunecker, A., Luke, W., and Kajalainen, K., Nature 331, 84–86, 1988.
Capon, J.D. et al., Nature 337, 525–531, 1989.
Motran, P. et al., Life Sci. 47, 993–999, 1990.
Mohan, P. et al.,, AIDS 4, 821–822, 1990.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Sarin, P.S., Goldstein, A., Agrawal, S., Zamecnik, P. (1992). Use of Drugs Targeted to Inhibit Different Stages of the HIV Life Cycle in the Treatment of AIDS. In: Goldstein, A.L., Garaci, E. (eds) Combination Therapies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3340-5_15
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3340-5_15
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6472-6
Online ISBN: 978-1-4615-3340-5
eBook Packages: Springer Book Archive