Skip to main content
SpringerLink
Log in

The Potential Role of Immunomodulation in the Treatment of HIV-Infection and Malignant Diseases

  • Chapter
Combination Therapies

  • 51 Accesses

Abstract

The AIDS epidemic continues to worsen worldwide.1 The incidence of malignant disease is also increasing.2 Cancer and AIDS can be considered to be related in several ways. In both, immunodeficiency is related to a poor prognosis.3, 4 Also, AIDS may be considered the most important of the clinical states which predisposed to malignancy and up to 20% of HIV seropositive subjects will eventually get malignant diseases.5 This suggests that immunorestorative therapy may be useful in both AIDS and cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Center for Disease Control, HIV Prevalence Estimates and AIDS Case Projections for the United States, MMWR, 39:1 (1990).

    Google Scholar 

  2. American Cancer Society. Cancer Statistics 1990. CA, 40:9 (1990).

    Google Scholar 

  3. J. J. Goedert, C. M. Kessler, L. M. Aledort, R. J. Biggar, W. A. Andes, G. C. White II, J. E. Drummond, K. Vaidya, D. L. Mann, M. E. Eyster, M. V. Ragni, M. M. Lederman, A. R. Cohen, G. L. Bray, P. S. Rosenberg, R. M. Friedman, M. W. Hilgartner, W. A. Blattner, B. Kroner, and M. H. Gail. A prospective study of human immunodeficiency virus type 1 infection and the development of AIDS in subjects with hemophilia, N Engl J Med, 321:1141 (1989).

    Article  PubMed  CAS  Google Scholar 

  4. E. M. Hersh, J. U. Gutterman, G. M. Mavligit, C. W. Mountain, C. M. McBride, and M. A. Burgess, Immunocompetence and immunodeficiency and prognosis in cancer, Ann NY Acad Sci, 276:386 (1976).

    Article  PubMed  CAS  Google Scholar 

  5. L. D. Kaplan, D. I. Abrams, E. Feigal, M. McGrath, J Kahn, P. Neville, J. Ziegler, and P. A. Volberding. AIDS-associated non-hodgkin’s lymphoma in san francisco, JAMA, 261:719 (1989).

    Article  PubMed  CAS  Google Scholar 

  6. R. S. Schulof, G. L. Simon, M. B. Sztein, D. M. Parenti, R. A. DiGioia, J. W. Courtless, J. M. Orenstein, C. M. Kessler, P. D. Kind, S. Schlesselman, H. M. Paxton, M. R. Guroff, P. H. Naylor, and A. L. Goldstein. Phase I/II trial of thymosin fraction 5 and thymosin alpha one in HTLV-III seropositive subjects, J Biol Response Mod, 5:429 (1986).

    PubMed  CAS  Google Scholar 

  7. C. Pedersen, E. Sandstrom, C. S. Petersen, C. Norkrans, J. Gerstoft, A. Karlsson, K. C. Christensen, C. Hakansson, P. O. Phrson, J. O. Nielsen, H. J. Jurgensen, and Scandinavian Study Group. The efficacy of inosine pranobex in preventing the acquired immunodeficiency syndrome in patients with human immunodeficiency virus infection, N Engl J Med, 322:1757 (1990).

    Article  PubMed  CAS  Google Scholar 

  8. J. M. Lange, F. Oberling, A. Aleksijevic, A. Falkenrodt, and S. Mayer. Immunomodulation with diethyldithiocarbamate in patients with AIDS-related complex, Lancet, 2:1066 (1985).

    Article  Google Scholar 

  9. J. M. Lange, J. L. Touraine, C. Trepo, P. Choutet, M. Kirstetter, A. Falkenrodt, L Herviou, J. M. Livrozet, G. Retornaz, F. Touraine, G. Renoux, M. Renoux, M. Musset, J. Caraux, and the AIDS-Imuthiol French Study Group. Randomized, double-blind, placebo-controlled trial of ditiocarb sodium (’imuthiol’) in human immunodeficiency virus infection, Lancet, 24:702 (1988).

    Article  Google Scholar 

  10. G. W. Brewton, E. M. Hersh, A. Rios, P. W. A. Mansell, B. Hollinger, and J. M. Reuben. A pilot study of diethyldithiocarbamate in patients with acquired immune deficiency syndrome (AIDS) and the AIDS-related complex, Life Sciences, 45(26):2509 (1989).

    Article  PubMed  CAS  Google Scholar 

  11. E. C. Reisinger, P. Kern, M. Ernst, P. Bock, H. D. Flad, M. Dietrich and German DTC Study Group. Inhibition of HIV progression by ditiocarb, Lancet, 335:679 (1990).

    Article  PubMed  CAS  Google Scholar 

  12. L. A. Salzman. Animal models of retrovirus infection and their relationship to AIDS, Academic Press, Inc., New York (1986).

    Google Scholar 

  13. R. Namikawa, H. Kaneshima, M. Lieberman, I. L. Weissman, and J. M. McCune. Infection of the SCID-hu mouse by HIV-1, Science, 242:684 (1988).

    Article  Google Scholar 

  14. D. E. Mosier, R. A. Yetter, and H. C. Morse III. Retroviral induction of acute lymphoproliferative disease and profound immunosuppression in adult C57BL/6 mice, J Exp Med, 161:766 (1985).

    Article  PubMed  CAS  Google Scholar 

  15. J. A. Bilello, E. Tracey, B. Benjers, R. Yetter, and P. M. Hoffman. Murine retrovirus model systems for evaluating antiviral agents: Efficacy of AZT and DDC in vitro and in vivo. III International Conference on AIDS, 165 (1987).

    Google Scholar 

  16. E. M. Hersh, G. Brewton, D. Abrams, J. Bartlett, J. Galpin, P. Gill, R. Gorter, M. Gottlieb, J. Jonikas, S. Landesman, A. Levine, A. Marcel, E. A. Petersen, M. Whiteside, J. Zahradnik, C. Negron, F. Boutitie, J. Caraux, J. M. Dupuy, and L. R. Salmi. Ditiocarb sodium (diethyldithiocarbamate) therapy in patients with symptomatic HIV infection and AIDS. A randomized double-blind, placebo-controlled, multicenter study. JAMA, 265:1538 (1991).

    Article  PubMed  CAS  Google Scholar 

  17. G. Renoux and M. Renoux. The effects of sodium diethyldithiocarbamate, azathioprine, cyclophosphamide, or hydrocortisone acetate administered alone or in association for 4 weeks on the immune responses of BALC/c mice, Clin Immunol and Immunopath, 15:23 (1980).

    Article  CAS  Google Scholar 

  18. M. D. Halpern, E. Hersh, and D. E. Yocum. Diethyldithiocarbamate, a novel immunomodulator, prolongs survival in autoimmune MRL-1pr/lpr mice, Clin Immuno and Immunopath, 55:242 (1990).

    Article  CAS  Google Scholar 

  19. Y. Z. Patt, P. W. A. Mansell, J. M. Reuben, and E. M. Hersh. Effect of azimexon therapy on host defense parameters and disease associated symptoms in acquired immune deficiency syndrome (AIDS) and AIDS related complex (ARC), AIDS Research, 2:191 (1986).

    Article  PubMed  CAS  Google Scholar 

  20. U. F. Bicker. Immunopharmacological properties of 2-cyanaziridine derivatives, in: Immune Modulating Agents and Their Mechanisms, R. L. Fenichel and M. A. Chirigos, eds., Marcel Dekker, New York (1984).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The University of Arizona Health Sciences Center, Tucson, Arizona, 85724, USA

    Evan M. Hersh, Carole Y. Funk & Eskild A. Petersen

Authors
  1. Evan M. Hersh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Carole Y. Funk
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Eskild A. Petersen
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The George Washington University School of Medicine, Washington, D.C., USA

    Allan L. Goldstein

  2. University of Rome “Tor Vergata”, Rome, Italy

    Enrico Garaci

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer Science+Business Media New York

About this chapter

Cite this chapter

Hersh, E.M., Funk, C.Y., Petersen, E.A. (1992). The Potential Role of Immunomodulation in the Treatment of HIV-Infection and Malignant Diseases. In: Goldstein, A.L., Garaci, E. (eds) Combination Therapies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3340-5_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-3340-5_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6472-6

  • Online ISBN: 978-1-4615-3340-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation