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Combination Therapies pp 105–112Cite as

Treatment and Pharmacokinetics of Liposomal-Amphotericin B Patients with Systemic Fungal Infections

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Abstract

Opportunistic infections occur frequently in immunocompromised patients and in patients with cancer.1–3 In this latter group, systemic mycoses are one of the most frequent causes of infection-related morbidity and mortality.4–6 Intensive chemotherapy, the prolonged use of broad spectrum antibiotics, and inherent defects in host immunity related to the underlying disease are among the major predisposing factors for opportunistic infections in general.7–8 Early histologic diagnosis of systemic mycoses is often difficult in patients with hematologic malignancies due to thrombocytopenia. Delays in histologic and cultural diagnoses lead to delays in initiation of therapy. Antifungal therapy begins when empirically prompted by persistent fever in neutropenic patients in spite of the use of broad spectrum antibiotics. 9–10 The drug of choice for most fungal infections is Amphotericin B (AmpB, Fungizone®) which is particularly effective in non-neutropenic patients and often ineffective in the neutropenic patient.11,12

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Authors and Affiliations

  1. Departments of Medical Oncology and Clinical Immunology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA

    Gabriel Lopez-Berestein & Michael G. Rosenblum

Authors
  1. Gabriel Lopez-Berestein
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  2. Michael G. Rosenblum
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Editors and Affiliations

  1. The George Washington University School of Medicine, Washington, D.C., USA

    Allan L. Goldstein

  2. University of Rome “Tor Vergata”, Rome, Italy

    Enrico Garaci

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© 1992 Springer Science+Business Media New York

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Lopez-Berestein, G., Rosenblum, M.G. (1992). Treatment and Pharmacokinetics of Liposomal-Amphotericin B Patients with Systemic Fungal Infections. In: Goldstein, A.L., Garaci, E. (eds) Combination Therapies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3340-5_13

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  • DOI: https://doi.org/10.1007/978-1-4615-3340-5_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6472-6

  • Online ISBN: 978-1-4615-3340-5

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