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Formation of Excess Reactive Oxygen Species within the Brain

  • Chapter
The Vulnerable Brain and Environmental Risks

Abstract

The terms free radicals or oxygen radicals have become commonly used in the past decade as a result of overwhelming data suggesting that oxygen radicals are involved in a variety of disease processes. The works of Freeman and Crapo (1982) and Halliwell and Gutteridge (1985, 1989) especially have addressed the ubiquitous role of free radicals in the biology of disease and tissue injury. Most of the issues considered to date have dealt with the role of free radicals in the mechanisms of carcinogenesis, ischemia, and aging. In the field of toxicology, free-radical research has primarily focused in the area of pulmonary, cardiac, and hepatic toxicity.

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Authors and Affiliations

  1. Department of Community and Environmental Medicine, University of California, Irvine, California, 72717, USA

    Stephen C. Bondy

  2. Alkermes, Cambridge, Massachusetts, 02139, USA

    Carl P. LeBel

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  1. Stephen C. Bondy
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  2. Carl P. LeBel
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Editors and Affiliations

  1. Binghamton University, Binghamton, New York, USA

    Robert L. Isaacson

  2. U. S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA

    Karl F. Jensen

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© 1992 Springer Science+Business Media New York

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Bondy, S.C., LeBel, C.P. (1992). Formation of Excess Reactive Oxygen Species within the Brain. In: Isaacson, R.L., Jensen, K.F. (eds) The Vulnerable Brain and Environmental Risks. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3330-6_14

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  • DOI: https://doi.org/10.1007/978-1-4615-3330-6_14

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