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The Vulnerable Brain and Environmental Risks pp 215–234Cite as

Silver Impregnation of Organophosphorus-Induced Delayed Neuropathy in the Central Nervous System

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Abstract

The use of organophosphorus compounds is widespread in industry, finding such diverse applications as insecticides, flame retardants, plasticizers, petroleum additives, and intermediates in the manufacture of pharmaceuticals (Davis and Richardson, 1980; U.S. Environmental Protection Agency, 1985). It has been well documented that exposure to certain of these compounds may result in organophosphorus-induced delayed neurotoxicity (OPIDN), a neurological condition characterized by progressively developing hind-limb ataxia and paralysis, inhibition of the enzyme neuropathy target esterase (NTE), and development of axonal degeneration in both the central (CNS) and peripheral (PNS) nervous systems (Abou-Donia, 1981; Abou-Donia and Lapadula, 1990; Baron, 1981 Davis and Richardson, 1980; Johnson, 1975, 1982, 1990).

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Authors and Affiliations

  1. Department of Anatomy, Michigan State University, East Lansing, Michigan, 48824, USA

    Duke Tanaka Jr.

  2. Department of Animal Science, Michigan State University, East Lansing, Michigan, 48824, USA

    Steven J. Bursian & Ellen J. Lehning

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  1. Duke Tanaka Jr.
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  2. Steven J. Bursian
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  3. Ellen J. Lehning
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Editors and Affiliations

  1. Binghamton University, Binghamton, New York, USA

    Robert L. Isaacson

  2. U. S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA

    Karl F. Jensen

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Tanaka, D., Bursian, S.J., Lehning, E.J. (1992). Silver Impregnation of Organophosphorus-Induced Delayed Neuropathy in the Central Nervous System. In: Isaacson, R.L., Jensen, K.F. (eds) The Vulnerable Brain and Environmental Risks. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3330-6_12

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