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Neurotoxicity of Polychlorinated Biphenyls

The Role of Ortho-Substituted Congeners in Altering Neurochemical Function

  • Chapter
The Vulnerable Brain and Environmental Risks

Abstract

Polychlorinated biphenyls (PCBs) are members of a large class of organic compounds known as halogenated aromatic hydrocarbons. This class of compounds also includes 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,3,7,8-tetrachlorinated dibenzofuran (TCDF) (Fig. 1). These latter compounds are often contaminants of environmental and commercial mixtures of PCBs because small quantities of them may be produced either during the manufacturing process or when PCBs are heated in the absence of oxygen (Erickson, 1986a).

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References

  • Abramowicz, D.O., 1990, Aerobic and anaerobic biodegradation of PCBs: A review, Crit. Rev. Biotechnol. 10:241–251.

    Article  CAS  Google Scholar 

  • Adler, M.W., 1980, Opioid peptides, Life Sci. 26:497–510.

    Article  PubMed  CAS  Google Scholar 

  • Agrawal, A.K., Tilson, H.A., and Bondy, S.C., 1981, 3,4,3’,4’-Tetrachlorobiphenyl given to mice prenatally produces long term decreases in striatal dopamine and receptor binding sites in the caudate nucleus, Toxicol. Lett. 7:417–424.

    Article  PubMed  CAS  Google Scholar 

  • Amano, T., Richelson, E., and Nirenberg, M., 1972, Neurotransmitter synthesis by neuroblastoma clones, Proc. Natl. Acad. Sci. USA 69:258–263.

    Article  PubMed  CAS  Google Scholar 

  • Bakke, J.E., Feil, V.J., and Bergman, A., 1983, Metabolites of 2,4’,5’-trichlorobiphenyl in rats, Xenobiotica 13:555–564.

    Article  PubMed  CAS  Google Scholar 

  • Becker, J.B., and Beer, M.E., 1986, The influence of estrogen on nigrostriatal dopamine activity: Behavioral and neurochemical evidence for both pre-and postsynaptic components, Behay. Brain Res. 19:27–33.

    Article  CAS  Google Scholar 

  • Bedard, D.L., Unterman, R., Bopp, L.H., Brennan, M.J., Haberl, M.L., and Johnson, C., 1986, Rapid assay for screening and characterizing microorganisms for the ability to degrade polychlorinated biphenyls, Appl. Environ. Microbiol. 51:761768.

    Google Scholar 

  • Bird, E.D., Anton, A.H., and Bullock, B., 1984, The effect of manganese inhalation on basal ganglia dopamine concentrations in rhesus monkey, Neurotoxicology 5:59–66.

    PubMed  CAS  Google Scholar 

  • Bowman, R.E., Heironimus, M.P., and Barsotti, D.A., 1981a, Locomotor hyperactivity in PCB-exposed rhesus monkeys, Neurotoxicology 2:251–268.

    CAS  Google Scholar 

  • Bowman, R.E., and Heironimus, M.P., 1981b, Hypoactivity in adolescent monkeys perinatally exposed to PCBs and hyperactive as juveniles, Neurobehay. Toxicol. Teratol. 3:15–18.

    CAS  Google Scholar 

  • Brinkman, U.A.Th., and de Kok, A., 1980, Production, properties and usage, in: Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products (R.D. Kimbrough, ed.), Elsevier/North-Holland Biomedical Press, Amsterdam, pp. 1–40.

    Google Scholar 

  • Bush, B., and Barnard, E.L., 1982, Determination of nonpolar chlorinated hydrocarbons and PCB in microsamples, Anal. Lett. 15:1643–1648.

    Article  CAS  Google Scholar 

  • Bush, B., Snow, J., and Koblintz, R., 1984, Polychlorobiphenyl (PCB) congeners, p,p’-DDE, and hexachlorobenzene inmaternal and fetal cord blood from mothers in upstate New York, Arch. Environ. Contam. Toxicol. 13:517–527.

    Article  PubMed  CAS  Google Scholar 

  • Bush, B., Simpson, K.W., Shane, L., and Koblintz, R.R., I985a, PCB congener analysis of water and caddisfly larvae (Insecta: Trichoptera) in the upper Hudson River by glass capillary chromatography, Bull. Environ. Contam. Toxicol. 34:96–105.

    Article  Google Scholar 

  • Bush, B., Snow, J., Connor, S., and Koblintz, R., 1985b, Polychlorinated biphenyl congeners (PCBs), p,p’-DDE and hex-achlorobenzene in human milk in three areas of upstate New York, Arch. Environ. Contam. Toxicol. 14:443–450.

    Article  CAS  Google Scholar 

  • Bush, B., Shane, L.A., Wilson, L.R., Barnard, E.L., and Barnes, D., 1986, Uptake of polychlorobiphenyl congeners by purpleloosestrife (Lythrum salicaria) on the banks of the Hudson River, Arch. Environ. Contam. Toxicol. 15:285–290.

    Article  CAS  Google Scholar 

  • Bush, B., Shane, L.A., Wahlen, M., and Brown, M.P., 1987, Sedimentation of 74 PCB congeners in the upper Hudson River, Chemosphere 16:733–744.

    Article  CAS  Google Scholar 

  • Chen, M., Hong, C.S., Bush, B., and Rhee, G.-Y., 1988, Anaerobic biodegradation of polychlorinated biphenyls by bacteria from Hudson River sediments, Ecotoxicol. Environ. Safety 16:95–105.

    Article  CAS  Google Scholar 

  • Chou, S.M., Miike, T., Payne, W.M., and Davis, G.J., 1979, Neuropathology of “spinning syndrome” induced by prenatal intoxication with a PCB in mice, Ann. N.Y. Acad. Sci. 320:373–396.

    PubMed  CAS  Google Scholar 

  • Di Paolo, T., Poyet, P., and Labrie, F., 1982, Effect of prolactin and estradiol on rat striatal dopamine receptors, Life Sci. 31:2921–2929.

    Article  PubMed  Google Scholar 

  • Eadie, M.J., Sutherland, J.M., and Doherty, R.L., 1965, Encephalitis: Etiology of parkinsonism in Australia, Arch. Neurol. 12:240–245.

    Article  PubMed  CAS  Google Scholar 

  • Elsworth, J.D., Deutch, A.Y., Redmond, D.E. Jr., Sladek, J.R. Jr., and Roth, R.H., 1987, Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on catecholamines and metabolites in primate brain and CSF, Brain Res. 415:293–299.

    Article  PubMed  CAS  Google Scholar 

  • Erickson, M.D., 1986a, Analytical Chemistry of PCBs, Butterworth, Boston, pp. 5–53.

    Google Scholar 

  • Erickson, M.D., 1986b, Analytical Chemistry of PCBs, Butterworth, Boston, pp. 469–475.

    Google Scholar 

  • Eriksson, P., 1988, Effects of 3,3’,4,4’-tetrachlorobiphenyl in the brain of the neonatal mouse, Toxicology 49:43–48.

    Article  PubMed  CAS  Google Scholar 

  • Fagan, J.F., and McGrath, S.K., 1981, Infant recognition memory and later intelligence, Intelligence 5:121–130.

    Article  Google Scholar 

  • Fagan, J.F., Singer, L.T., Montie, J.E., and Shepherd, P.A., 1986, Selective screening device for the early detection of normalor delayed cognitive development in infants at risk for later mental retardation, Pediatrics 78:1021–1026.

    PubMed  Google Scholar 

  • Farrell, K., Safe, L., and Safe, S., 1987, Synthesis and aryl hydrocarbon receptor binding properties of radiolabeled polychlori-nated dibenzofuran congeners, Arch. Biochem. Biophys. 259:185–195.

    Article  PubMed  CAS  Google Scholar 

  • Fein, G.G., Jacobson, J.L., Jacobson, S.W., Schwartz, P.M., and Dowler, J.K., 1984, Prenatal exposure to polychlorinated biphenyls: Effects on birth size and gestational age, J. Pediatr. 105:315–320.

    Article  PubMed  CAS  Google Scholar 

  • Porno, L.S., 1982, Pathology of Parkinson’s disease, in: Movement Disorders (C.D. Marsden, and S. Fahn, eds.), Butterworth Scientific, London, pp. 25–40.

    Google Scholar 

  • Gierthy, J.F., Lincoln, D.W., Gillespie, M.B., Seeger, J.I., Martinez, H.L., Dickerman, H.W., and Kumar, S.A., 1987, Suppression of estrogen-regulated extracellular tissue plasminogen activator activity of MCF-7 cells by 2,3,7,8tetrachlorodibenzo-p-dioxin, Cancer Res. 47:6198–6203.

    PubMed  CAS  Google Scholar 

  • Gladen, B., and Rogan, W., 1988, Decrements on six-month and one-year Bayley scores and prenatal polychlorinated biphenyl (PCB) exposure, Am. J. Epidemiol. 128:912.

    Google Scholar 

  • Gladen, B.C., Rogan, W.J., Hardy, P., Thullen, J., Tingelstad, J., and Tully, M., 1988, Development after exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene transplacentally and through human milk, J. Pediatr. 113:991–995.

    Article  PubMed  CAS  Google Scholar 

  • Glick, S.D., and Shapiro, R.M., 1985, Functional and neurochemical mechanisms of cerebral lateralization in rats, in: Cerebral Lateralization in Nonhuman Species (S.D. Glick, ed.), Academic Press, Orlando, pp. 157–183.

    Google Scholar 

  • Glick, S.D., Meibach, R.C., Cox, R.D., and Maayani, S., 1979, Multiple and interrelated functional asymmetries in the brain, Life Sci. 25:395–400.

    Article  PubMed  CAS  Google Scholar 

  • Graham, D.G., 1978, Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones, Mol. Pharmacol. 14:633–643.

    PubMed  CAS  Google Scholar 

  • Greene, L.A., and Rein, G., 1977, Release, storage and uptake of catecholamines by a clonal cell line of nerve growth factor (NGF) responsive pheochromocytoma cells, Brain Res. 129:247–263.

    Article  PubMed  CAS  Google Scholar 

  • Greene, L.A., and Tischler, A.S., 1976, Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor, Proc. Natl. Acad. Sci. USA 73:2424–2428.

    Article  PubMed  CAS  Google Scholar 

  • Hansen, L.G., 1987, Environmental toxicology of polychlorinated biphenyls, in: Polychlorinated Biphenyls (PCBs): Mam-malian and Environmental Toxicology (S. Safe, and O. Hutzinger, eds.), Springer-Verlag, New York, pp. 15–48.

    Chapter  Google Scholar 

  • Harada, M., 1976, Intrauterine poisoning: Clinical and epidemiological studies of the problem, Bull. Inst. Const. Med. 25:1–60.

    Google Scholar 

  • Hayes, M.A., 1987, Carcinogenic and mutagenic effects of PCBs, in: Polychlorinated Biphenyls (PCBs): Mammalian andEnvironmental Toxicology (S. Safe, and O. Hutzinger, eds.), Springer-Verlag, New York, pp. 77–95.

    Chapter  Google Scholar 

  • Hsu, S.-T., Ma, C.-I., Hsu, S.K.-H., Wu, S.-S., Hsu, N.H.-M., Yeh, C.-C., and Wu, S.-B., 1985, Discovery and epidemiolo-gy of PCB poisoning in Taiwan: A four-year followup, Environ. Health Perspect. 59:5–10.

    Article  PubMed  CAS  Google Scholar 

  • Hutzinger, O., Safe, S., and Zitko, V., 1974, The Chemistry of PCB’s, CRC Press, Cleveland, OH.

    Google Scholar 

  • Jacobson, J.L., Fein, G.G., Jacobson, S.W., Schwartz, P.M., and Dowler, J.K., 1984a, The transfer of polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs) across the human placenta and into maternal milk, Am. J. Public Health 74:378–379.

    Article  CAS  Google Scholar 

  • Jacobson, J.L., Jacobson, S.W., Schwartz, P.M., Fein, G.G., and Dowler, J.K., 1984b, Prenatal exposure to an environmental toxin: A test of the multiple effects model, Dew. Psychol. 20(4):523–532.

    Article  Google Scholar 

  • Jacobson, J.L., Jacobson, S.W., and Humphrey, H.E.B., 1990, Effects of in utero exposure to polychlorinated biphenyls and related contaminants on cognitive functioning in young children, J. Pediatr. 116:38–45.

    Article  PubMed  CAS  Google Scholar 

  • Jacobson, S.W., Fein, G.G., Jacobson, J.L., Schwartz, P.M., and Dowler, J.K., 1985, The effect of intrauterine PCB exposure on visual recognition memory, Child Dev. 56:853–860.

    Article  PubMed  CAS  Google Scholar 

  • Kittner, B., Brautigam, M., and Herken, H., 1987, PC12 cells: A model system for studying drug effects on dopamine synthesis and release, Arch. Int. Pharmacodyn. Ther. 286:181–194.

    PubMed  CAS  Google Scholar 

  • Kuratsune, M., 1980, Yusho, in: Halogenated Biphenyls, Terphenyls, Napthalenes, Dibenzodioxins and Related Products (R.D. Kimbrough, ed.), Elsevier/North-Holland, Amsterdam, pp. 287–302.

    Google Scholar 

  • Kuratsune, M., Youshimara, T., Matsuzaka, J., and Yamaguchi, A., 1972, Epidemiologic study on Yusho: A poisoning caused by ingestion of rice oil contaminated with a commercial brand of polychlorinated biphenyls, Environ. Health Perspect. 1:119–128.

    CAS  Google Scholar 

  • Kuroiwa, Y., Murai, Y., and Santa, T., 1969, Neurological and nerve conduction velocity studies on 23 patients with chlorobiphenyls poisoning, Fukuoka Igaku Zasshi 60:446–462.

    Google Scholar 

  • Levin, E.D., Schantz, S.L., and Bowman, R.E., 1988, Delayed spatial alteration deficits resulting from perinatal PCB exposure in monkeys, Arch. Toxicol. 62:267–273.

    Article  PubMed  CAS  Google Scholar 

  • Lindvall, O., and Björklund, A., 1983, Dopamine-and noradrenaline-containing neuron systems: Their anatomy in the rat brain, in: Chemical Neuroanatomy (P.C. Emson, ed.), Raven Press, New York, pp. 229–255.

    Google Scholar 

  • Lii, Y.-C., and Wong, P.-N., 1984, Dermatological, medical, and laboratory findings of patients in Taiwan and their treatments, in: PCB Poisoning in Japan and Taiwan (M. Kuratsune, and R.E. Shapiro, eds.), Alan R. Liss, New York, pp. 81–115.

    Google Scholar 

  • Mackay, D., Paterson, S., Eisenreich, S.J., and Simmons, M.S., 1983, Physical Behavior of PCBs in the Great Lakes, AnnArbor Science Publishers, Ann Arbor, MI.

    Google Scholar 

  • Matthews, H.B., 1981, Disposition of persistent halogenated hydrocarbons in higher animals, in: Toxicology of Halogenated Hydrocarbons, Health and Ecological Effects (M.A.Q. Khan, and R.H. Stanton, eds.), Pergamon Press, New York, pp. 259–270.

    Google Scholar 

  • Mullin, M.D., Pochini, C.M., McCrindle, S., Romkes, M., Safe, S.H., and Safe, L.M., 1984, High-resolution PCB analysis: Synthesis and chromatographic properties of all 209 PCB congeners, Environ. Sci. Technol. 18:468–476.

    Article  Google Scholar 

  • National Research Council, 1979, Polychlorinated Biphenyls, National Academy of Sciences, Washington, D.C.

    Google Scholar 

  • Norstrom, R.J., Simon, M., Muir, D.C.G., and Schweinbsburg, R.E., 1988, Organochlorine contaminants in Arctic marinefood chains: Identification, geographical distribution and temporal trends in polar bears, Environ. Sci. Technol. 22:1063–1071.

    Article  PubMed  CAS  Google Scholar 

  • Overmann, S.R., Kostas, J., Wilson, L.R., Shain, W., and Bush, B., 1987, Neurobehavioral and somatic effects of perinatal PCB exposure in rats, Environ. Res. 44:56–70.

    Article  PubMed  CAS  Google Scholar 

  • Panek, D.U., and Dixon, W.R., 1985, Effect of intraventricular administration of catechol estrogens on catecholamine content in various brain regions, Brain Res. 340:87–90.

    Article  PubMed  CAS  Google Scholar 

  • Pantaleoni, G., Fanini, D., Sponta, A.M., Palumbo, G., Giorgi, R., and Adams, P.M., 1988, Effects of maternal exposure topolychlorinated biphenyls (PCBs) on Fl generation behavior in the rat, Fundam. Appl. Toxicol. 11:440–449.

    Article  PubMed  CAS  Google Scholar 

  • Parkinson, A., and Safe, S., 1987, Mammalian biologic and toxic effects of PCBs, in: Polychlorinated Biphenyls (PCBs): Mammalian and Environmental Toxicology (S. Safe, and O. Hutzinger, eds.), Springer-Verlag, New York, pp. 49–75.

    Chapter  Google Scholar 

  • Peters, H.A., Levine, R.L., Matthews, C.G., and Chapman, L.J., 1988, Extrapyramidal and other neurologic manifestationsassociated with carbon disulfide fumigant exposure, Arch. Neurol. 45:537–540.

    Article  PubMed  CAS  Google Scholar 

  • Poland, A., Glover, E., and Kende, A.S., 1976, A stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol: Evidence that the binding species is the receptor for induction of aryl hydrocarbon hydroxylase, J. Biol. Chem. 251:4936–4946.

    PubMed  CAS  Google Scholar 

  • Robertson, L.W., Parkinson, A., Bandiera, S., Lambert, I., Merrill, J., and Safe, S., 1984, PCBs and PBBs: Biologic and toxic effects on C57BL/6J and DBA/2J mice, Toxicology 31:191–206.

    Article  PubMed  CAS  Google Scholar 

  • Rogan, W.J., Gladen, B.C., McKinney, J.D., Carreras, N., Hardy, P., Thullen, J.D., Tinglestad, J., and Tully, M., 1986, Neonatal effects of transplacental exposure to PCBs and DDE, J. Pediatr. 109:335–341.

    Article  PubMed  CAS  Google Scholar 

  • Rogan, W.J., Gladen, B.C., Hung, K.L., Koong, S.L., Shih, L.Y., Taylor, J.S., Wu, Y.C., Yang, D., Rogan, N.B., and Hsu, C.C., 1988, Congenital poisoning by polychlorinated biphenyls and their contaminants in Taiwan, Science 241:334–336.

    Article  PubMed  CAS  Google Scholar 

  • Ryerson, B.A., Carter, D.E., and Sipes, LG., 1984, Comparison of 2,2’,4,4’,5,5’-hexachloro[14C]biphenyl levels in differentadipose tissues of dogs and monkeys, Fundam. Appl. Toxicol. 4:120–124.

    Article  PubMed  CAS  Google Scholar 

  • Safe, S., 1980, Metabolism, uptake, storage and bioaccumulation, in: Halogenated Biphenyls, Terphenyls, Napthalenes, Dibenzodioxins and Related Products (R.D. Kimbrough, ed.), Elsevier/North Holland Biomedical Press, New York, pp. 81–107.

    Google Scholar 

  • Safe, S., 1990, Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: Environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs), CRC Crit. Rev. Toxicol. 21:51–88.

    Article  CAS  Google Scholar 

  • Safe, S., Safe, L., and Mullin, M., 1987, Polychlorinated biphenyls: Environmental occurrence and analysis, in: Polychlorinated Biphenyls (PCBs): Mammalian and Environmental Toxicology (S. Safe, and O. Hutzinger, eds.), Springer-Verlag, Berlin, pp. 1–13.

    Chapter  Google Scholar 

  • Sawaguchi, T., Matsumura, M., and Kubota, K., 1988, Dopamine enhances the neuronal activity of spatial short-term memory task in the primate prefrontal cortex, Neurosci. Res. 5:465–473.

    Article  PubMed  CAS  Google Scholar 

  • Sawaguchi, T., Matsumura, M., and Kubota K., 1989, Delayed response deficits produced by local injection of bicuculline into the dorsolateral prefrontal cortex in Japanese macaque monkeys, Exp. Brain Res. 75:457–469.

    Article  PubMed  CAS  Google Scholar 

  • Schantz, S.L., Levin, E.D., Bowman, R.E., Heironimus, M.P., and Laughlin, N.K., 1989, Effects of perinatal PCB exposure on discrimination-reversal learning in monkeys, Neurotoxccol. Teratol. 11:243–250.

    Article  CAS  Google Scholar 

  • Seegal, R.F., 1992, Perinatal exposure to Aroclor 1016 elevates brain dopamine concentrations in the rat, The Toxicologist 12(1):320.

    Google Scholar 

  • Seegal, R.F., Bush, B., and Brosch, K.O., 1985, Polychlorinated biphenyls induce regional changes in brain norepinephrine concentrations in adult rats, Neurotoxicology 6:13–24.

    PubMed  CAS  Google Scholar 

  • Seegal, R.F., Brosch, K.O., and Bush, B., 1986a, High-performance liquid chromatography of biogenic amines and metabolites in brain, cerebrospinal fluid, urine and plasma, J. Chromatogr. 377:131–144.

    Article  CAS  Google Scholar 

  • Seegal, R.F., Brosch, K.O., and Bush, B., 1986b, Polychlorinated biphenyls produce regional alterations of dopamine metabolism in rat brain, Toxicol. Lett. 30:197–202.

    Article  CAS  Google Scholar 

  • Seegal, R.F., Brosch, K.O., and Bush, B., 1986c, Regional alterations in serotonin metabolism induced by oral exposure of rats to polychlorinated biphenyls, Neurotoxicology 7:155–166.

    CAS  Google Scholar 

  • Seegal, R.F., Brosch, K., Bush, B., Ritz, M., and Shain, W., 1989, Effects of Aroclor 1254 on dopamine and norepinephrine concentrations in pheochromocytoma (PC-12) cells, Neurotoxicology 10:757–764.

    PubMed  CAS  Google Scholar 

  • Seegal, R.F., Bush, B., and Shain, W., 1990, Lightly chlorinated ortho-substituted PCB congeners decrease dopamine in nonhuman primate brain and in tissue culture, Toxicol. Appl. Pharmacol. 106:136–144.

    Article  PubMed  CAS  Google Scholar 

  • Seegal, R.F., Bush, B., and Brosch, K.O., 1991a, Comparison of effects of Aroclors 1016 and 1260 on nonhuman primate catecholamine function, Toxicology 66:145–163.

    Article  CAS  Google Scholar 

  • Seegal, R.F., Bush, B., and Brosch, K.O., 1991b, Sub-chronic exposure of the adult rat to Aroclor 1254 yields regionally-specific changes in central dopaminergic function, Neurotoxicology 12:55–66.

    CAS  Google Scholar 

  • Seegal, R.F., Bush, B., and Shain, W., 1991c, Neurotoxicology of ortho-substituted polychlorinated biphenyls, Chemosphere 23:1941–1949.

    Article  CAS  Google Scholar 

  • Shain, W., Overmann, S.R., Wilson, L.R., Kostas, J., and Bush, B., 1986, A congener analysis of polychlorinated biphenyls accumulating in rat pups after perinatal exposure, Arch. Environ. Contam. Toxicol. 15:687–707.

    Article  PubMed  CAS  Google Scholar 

  • Shain, W., Bush, B., and Seegal, R.F., 1991, Neurotoxicity of polychlorinated biphenyls: Structure-activity relationship of individual congeners, Toxicol. Appl. Pharmacol. 11:33–42.

    Article  Google Scholar 

  • Shiota, K., 1976, Postnatal behavioral effects of prenatal treatment with PCBs (polychlorinated biphenyls) in rats, Okajimas Folia Anat. Jpn. 53:105–114.

    PubMed  CAS  Google Scholar 

  • Silkworth, J.B., Antrim, L., and Kaminsky, L.S., 1984, Correlations between polychlorinated biphenyl immunotoxicity, the aromatic hydrocarbon locus and liver microsomal enzyme induction in C57BL/6J and DBA/2 mice, Toxicol. Appl. Pharmacol. 75:156–165.

    Article  PubMed  CAS  Google Scholar 

  • Silkworth, J.B., Antrim, L., and Sack, G., 1986, Ah receptor mediated suppression of the antibody response in mice is primarily dependent on the Ah phenotype of lymphoid tissue, Toxicol. Appl. Pharmacol. 86:380–390.

    Article  PubMed  CAS  Google Scholar 

  • Spagnoli, J., and Skinner, L., 1979, PCBs in fish from selected waters of New York State, Pesticide Monitoring J. 11:69–87.

    Google Scholar 

  • Suenaga, N., Yamada, K., Hidaka, T., and Fukuda, T., 1975, Influences of PCB on the brain catecholamine levels in rats, Fukuoka Igaku Zasshi 66:589–592.

    PubMed  CAS  Google Scholar 

  • Sundstrom, G., Hutzinger, O., and Safe, S., 1976, The Metabolism of chlorobiphenyls—A review, Chemosphere 5:267–298.

    Article  CAS  Google Scholar 

  • Tanabe, S., Hidaka, H., and Tatsukawa, R., 1983, PCBs and chlorinated hydrocarbon pesticides in Antarctic atmosphere and hydrosphere, Chemosphere 12:277–288.

    Article  CAS  Google Scholar 

  • Tilson, H.A., Davis, G.J., McLachlan, J.A., and Lucier, G.W., 1979, The effects of polychlorinated biphenyls given prenatally on the neurobehavioral development of mice, Environ. Res. 18:466–474.

    Article  PubMed  CAS  Google Scholar 

  • Wasserman, M., Wasserman, D., Cucos, S., and Miller, H.J., 1979, World PCBs map: Storage and effects in man and his biologic environment in the 1970s, Ann. N.Y. Acad. Sci. 320:69–124.

    Google Scholar 

  • World Health Organization, 1976, Polychlorinated Biphenyls and Terphenyls. Environmental Health Criteria 2, World Health Organization, Geneva.

    Google Scholar 

  • Yalkowsky, S.H., Valvani, S.C., and Mackay, D., 1983, Estimation of the aqueous solubility of some aromatic compounds, Residue Rev. 85:43–55.

    Article  CAS  Google Scholar 

  • Yamaguchi, A., Yoshimura, T., and Kuratsune, M., 1971, A survey on pregnant women having consumed rice oil contaminated with chlorobiphenyls and their babies, Fukuoka Igaku Zasshi 62:112–117.

    Google Scholar 

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Authors and Affiliations

  1. New York State Department of Health, Wadsworth Center for Laboratories and Research, Albany, New York, 12201, USA

    Richard F. Seegal

  2. School of Public Health, State University of New York at Albany, Albany, New York, 12203, USA

    William Shain

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  1. Richard F. Seegal
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  1. Binghamton University, Binghamton, New York, USA

    Robert L. Isaacson

  2. U. S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA

    Karl F. Jensen

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Seegal, R.F., Shain, W. (1992). Neurotoxicity of Polychlorinated Biphenyls. In: Isaacson, R.L., Jensen, K.F. (eds) The Vulnerable Brain and Environmental Risks. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3330-6_10

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