Abstract
The polyamines putrescine, spermidine, spermine, and their acetylated derivatives are a group of ubiquitously distributed organic polycations. Although their exact physiological function has not been elucidated fully at the molecular level, these amines are required for normal cell growth and differentiation. Very little is known about the function of polyamines in the gastrointestinal tract, although interest in and knowledge of this area is rapidly expanding.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Luk GD, Marton LJ, Baylin SB. Ornithine decarboxylase is important in intestinal mucosal maturation and recovery from injury in the rat. Science 1980; 210: 195–198.
Luk GD, Baylin SB. Polyamines and intestinal growth—increased polyamine biosynthesis after jejunectomy. Am J Physiol 1983; 245 (Gastroinaest Liver Physiol 8):G656–G660.
Yang P, Baylin SB, Luk GD. Polyamines and intestinal growth: absolute requirement for ODC activity in adaptation during lactation. Am J Physiol Gastrointest Liver Physiol 10) 1984; 247: G553–G5
Seidel ER, Haddox MK, Johnson LR. Polyamines in the response to intestinal obstruction. Am J Physiol 1984; 246 (Gastrointest Liver Physiol 9):G649–G653.
Dowling RH, Hosomi M, Stace NH, et al. Hormones and polyamines in intestinal and pancreatic adaptation. Scand J Gastroenterol 1985; 112 (Suppl):84–95.
Crean GP, Hogg DF, Rumsey RDE. Hyperplasia of the gastric mucosa produced by duodenal obstruction. Gastroenterology 1969; 56: 193–199.
Burnham D. Epithelial cell production and mucosal morphology in colonic obstruction. Cell Tissue Res 1983; 230: 185–196.
Ecknauer R, Clarke RM, Meyer H. Acute distal intestinal obstruction in gnotobiotic rats. Virchows Arch B 1977; 25: 151–160.
Tabor CE, Tabor H. Polyamines in microorganisms. Microbiol Rev 1985; 49: 81–99.
Seidel ER, Haddox MK, Johnson LR. Heal mucosal growth during intraluminal infusion of ethylamine or putrescine. Am J Physiol (Gastrointest Liver Physiol 12) 249: G434–G438, 1985.
Canellakis ZN, Heller JS, Kyriakidis DA, Chen KY. Intracellular levels of ornithine decarboxylase, its half-life, and a hypothesis relating polyamine-sensitive membrane receptors to growth. Adv Polyamine Res 1978; 1: 17–30.
Canellakis ZN, Lande LA, Brody PK. Factors mediating the activity of ornithine decarboxylase in rat HTC cells. Med. Biol 1981; 59: 300–307.
Kumagai J, Wang P, Johnson LR. Stimulation of putrescine uptake in isolated enterocytes by refeeding. Gastroenterology 1987; 92: 1483.
Mizui T, Doteuchi M. Effect of polyamines on acidified ethanol-induced gastric lesions in rats. Jpn J Pharmacol 1983; 33: 939–945.
Steiner M, Boughes HR, Freeman LS, Gray SJ. Effect of starvation on the tissue composition of the small intestine in the rat. Am J Physiol 1968; 215: 75–77.
Levine GM, Deren E, Steiger E, Zinno R. Role of oral intake in maintenance of gut mass and disaccharide activity. Gastroenterology 1974; 67: 975–982.
Antony P, Gibson KI, Harris P. Ornithine decarboxylase activity in the isolated perfused rat heart. Biochem Soc Trans 1975; 3: 272–274.
Oka T, Perry JW. Studies on regulatory factors of ornithine decarboxylase activity during development of mouse mammary epithelium in vitro. J Biol Chem 1976; 251: 1738–1744.
Panko WB, Kenney FT. Hormonal stimulation of hepatic ornithine decarboxylase. Biochem Biophys Res Commun 1971; 43: 346–350.
Icekson I, Kaye AM, Lieberman ME, et al. Stimulating by luteinizing hormone of ornithine decarboxylase in rat ovary: preferential response by follicular tissue. J Endocrinol 1974; 417–418.
Feldman EJ, Aures D, Grossman MI. Epidermal growth factor stimulates ornithine decarboxylase activity in the digestive tract of the mouse. Proc Soc Exp Biol Med 1978; 159: 400–402.
Gleeson MH, Bloom SR, Polak JM, et al. Endocrine tumor in kidney affecting small bowel structure, motility, and absorptive function. Gut 1971; 12: 773–782.
Seidel ER, Tabata K, Dembinski AB, Johnson LR. Attenuation of the trophic response to gastrin after inhibition of ornithine decarboxylase. Am J Physiol (Gastrointest Liver Physiol 12) 1985; 249: G16–G20
Danzin C, Bolkenius FN, Claverie N, et al. Secretin-induced accumulation of N’-acetylsper-midine and putrescine in the rat pancreas. Biophys Biochem Res Commun 1982; 109: 1234–1236.
Weser E, Hernadez MH. Studies of small bowel adaptation after intestinal resection in the rat. Gastroenterology 1971; 60: 69–75.
Booth CC, Evan KT, Menzies T, Street DF. Intestinal hypertrophy following partial resection of the small bowel in the rat. Br J Surg 1956; 46: 403–410.
Bowen JC, Paddock GC, Bush JC, et al. Comparison of gastric responses to small bowel intestinal resection and bypass in rats. Surgery 1977; 83: 402–405.
Haarstad H, Winnberg A, Petersen H. Effects of a cholecystokinin-like peptide on DNA and polyamine synthesis in the rat pancreas. Scand J Gastroenterology 1985; 20: 530–538.
Benrezzak O, Morisset J. Effects of difluoromethylorninthine on pancreatic growth induced by caerulein. Reg Peptides 1984; 9: 143–153.
Tomas M, Poso H, Lapinjoki SP, et al. Growth signal transduction: rapid activation of covalently bound ornithine decarboxylase during phosphatidylinositol breakdown. Cell 1987; 49: 171–176.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Seidel, E.R. (1992). Cellular Mechanisms. In: Thomson, A.B.R., Shaffer, E. (eds) Modern Concepts in Gastroenterology. Topics in Gastroenterology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3314-6_2
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3314-6_2
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6459-7
Online ISBN: 978-1-4615-3314-6
eBook Packages: Springer Book Archive