Abstract
There have been several new directions that experimental workers have taken in the understanding of cholesterol gallstones in the recent past. In the pathogenesis, these are the description and role of biliary vesicles,1-3 nucleating4-6 and antinucleating7 factors, and somatostatin, which inhibits gallbladder contraction and which, when produced by tumors, is associated with gallstones.8 As for treatment, developments include rapid solvent dissolution,9 combination therapy of the ursodeoxycholic acid and the chenodeoxycholic acid,10 the role of diet,11 the use of 7-methyl-trihydroxy bile-acid analogues,12 and extracorporeal shock-wave therapy13 for the dissolution of stones in the gallbladder and common duct. With improved equipment, shock-wave therapy does not require bath immersion or a general anesthetic.
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© 1992 Springer Science+Business Media New York
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Williams, C.N. (1992). Cholesterol Gallstones. In: Thomson, A.B.R., Shaffer, E. (eds) Modern Concepts in Gastroenterology. Topics in Gastroenterology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3314-6_11
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DOI: https://doi.org/10.1007/978-1-4615-3314-6_11
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