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Modulators of Neural Cell Signaling and Triggering of Gene Expression following Cerebral Ischemia

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Neurochemical Correlates of Cerebral Ischemia

Part of the book series: Advances in Neurochemistry ((ANCH,volume 7))

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Abstract

Changes in brain lipids are a well-known correlate of cerebral ischemia involving free fatty acids, especially free arachidonic and docosahexaenoic acids, which reflects phospholipase A2 activation (Bazan, 1970). An additional early correlate in ischemia is the activation of phospholipase C, since diacylglycerols also accumulate (Bazan, 1970; Aveldano and Bazan, 1915a). The predominant fatty acid of the diacylglycerol pool that accumulates is 1-stearoyl-2-arachidonoyl sn-glycerol, as it is in the inositol lipids (phosphatidylinositol, phosphatidylinositol 4’-phosphate, and phosphatidylinositol 4’5’-bisphosphate). Therefore this neurochemical correlate of ischemia reflects inositol lipid degradation (Aveldano and Bazan, 1975a; Ikeda et al., 1986) and has been postulated to be linked to synaptic vulnerability under these conditions (Aveldano and Bazan, 1975a).

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References

  • Aveldano M. I., and Bazan, N. G., 1919a, Rapid production of diacylglycerols enriched in arachidonate and stearate during early brain ischemia, J. Neurochem. 25:919–920.

    Article  Google Scholar 

  • Aveldano M. I., and Bazan, N. G., 1975b, Differential lipid deacylation during brain ischemia in a homeotherm and a poikilotherm. Content and composition of free fatty acids and triacyl-glycerols, Brain Res. 100:99–110.

    Article  PubMed  CAS  Google Scholar 

  • Aveldano de Caldironi M. I., and Bazan, N. G., 1979, Alpha-methyl-p-tyrosine inhibits the production of free arachidonic acid and diacylglycerols in brain after a single electroconvulsive shock, Neurochem. Res. 4:213–221.

    Article  Google Scholar 

  • Bazan, H. E. P., Martin R. E., Tao, Y., and Bazan, N. G., 1990, Trigeminal neurons respond to injury of their sensory terminals in cornea by increasing levels of GAP-43 (growth associated protein-43) protein and mRNA, Soc. Neurosci. 16:164.

    Google Scholar 

  • Bazan, N. G., 1970, Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain, Biochim. Biophys. Acta 218:1–10.

    Article  PubMed  CAS  Google Scholar 

  • Bazan, N. G., 1971, Free fatty acid production in cerebral white and grey matter of the squirrel monkey, Lipids 6:211–212.

    Article  PubMed  CAS  Google Scholar 

  • Bazan, N. G., 1989a, Lipid-derived metabolites as possible retina messengers; Arachidonic acid, leukotrienes, docosanoids, and platelet-activating factor, in “Extracellular and Intracellular Messengers in the Vertebrate Retina Neurobiology” (D. Redburn and H. Pasantes Morales, eds.), pp. 269–300, Alan R. Liss, New York.

    Google Scholar 

  • Bazan, N. G., 1989b, Ginkgolide B (BN 52021) decreases brain phospholipase A2 activated by ischemia or electroconvulsive shock, in “Ginkgolide-Chemistry, Biology, Pharmacology and Clinical Perspectives,” vol. II (P. Braquet, ed.), pp. 629–637, J. R. Prous Science, Barcelona, Spain.

    Google Scholar 

  • Bazan, N. G., 1990, Neuronal cell transduction and second messengers in cerebral ischemia, in “Pharmacology of Cerebral Ischemia” (J. Krieglstein and H. Oberpichler, eds.), pp. 391–398, Wissenschaftliche Verlagsgesellschaft, Stuttgart, Germany.

    Google Scholar 

  • Bazan N. G., and Bazan, H. E. P., 1990, Ocular responses to inflammation and the triggering of wound healing: Lipid mediators, proto-oncogenes, gene expression and neuromodulation, in “New Trends in Lipid Mediators Research. Lipid Mediators in Eye Inflammation,” vol. 5 (N. G. Bazan, ed.), pp. 168–180, Karger, Basel, Switzerland.

    Google Scholar 

  • Bazan N. G., and Rakowski, H., 1970, Increased levels of brain free fatty acids after electroconvulsive shock, Life Sci. 9:501–507.

    Article  PubMed  CAS  Google Scholar 

  • Bazan N. D., Bazan, H. E. P., Kennedy W. G., and Joel, C. D., 1971, Regional distribution and rate of production of free fatty acids in rat brain, J. Neurochem. 18:1387–1393.

    Article  PubMed  CAS  Google Scholar 

  • Bazan N. G., Ilincheta de Boschero M. G., Giusto N. M., and Bazan, H. E. P., 1976, De novo glycerolipid biosynthesis in the toad and cattle retina. Redirecting of the pathway by propranolol and phentolamine, in “Function and Metabolism of Phospholipids in the Central and Peripheral Nervous System,” vol. 72 (G. Porcellati, L. Amaducci, and C. Galli, eds.), pp. 139–148, Plenum Press, New York.

    Chapter  Google Scholar 

  • Bazan N. G., Morelli de Liberti S. M., and Rodriguez de Türco, E. B., 1982, Arachidonic acid and arachidonoyl-diglycerides increase in rat cerebrum during bicuculline-induced status epilep-ticus, Neurochem. Res. 7:839–843.

    Article  PubMed  CAS  Google Scholar 

  • Birkle D. L., and Bazan, N. G., 1987, Effect of bicuculline-induced status epilepticus on prostaglandins and hydroxyeicosatetraenoic acids in rat brain subcellular fractions, J. Neurochem. 48: 1768–1778.

    Article  PubMed  CAS  Google Scholar 

  • Birkle D. L., Kurian, P., Braquet, P., and Bazan, N. G., 1988, The platelet-activating factor antagonist BN 52021 decreases accumulation of free polyunsaturated fatty acid in mouse brain during ischemia and electroconvulsive shock, J. Neurochem. 51:1900–1905.

    Article  PubMed  CAS  Google Scholar 

  • Bussolino, F., Gremo, F., Tetta, C., Pescarmona G. P., and Camussi, G., 1986, Production of platelet-activating factor by chick retina, J. Biol. Chem. 261:16502–16508.

    PubMed  CAS  Google Scholar 

  • Cendella R. J., Galli, C., and Paoletti, R., 1975, Brain free fatty acid levels in rats sacrificed by decapitation versus focused microwave irradiation, Lipids 10:290–293.

    Article  Google Scholar 

  • Choi, D. W., 1990, Cerebral hypoxia: Some new approaches and unanswered questions, J. Neurosci. 10:2493–2501.

    PubMed  CAS  Google Scholar 

  • Edgar A. D., Strosznajder, J., and Horrocks, L. A., 1982, Activation of ethanolamine phospholipase A2 in brain during ischemia, J. Neurochem. 39:1111–1116.

    Article  PubMed  CAS  Google Scholar 

  • Gilboe D. D., Fitzpatrick J. H., Jr., Kintner, D., Emoto S. E., Bazan N. G., and Braquet, P., 1989, Biochemical changes in normoxic and post-ischemic brain tissue following treatment with BN 52021, in “Ginkgolide—Chemistry, Biology, Pharmacology and Clinical Perspectives,” vol. II (R Braquet, ed.), pp. 639–648, J. R. Prous Science, Barcelona, Spain.

    Google Scholar 

  • Gilboe D. D., Kinter, D., Fitzpatrick J. H., Jr., Emoto S. E., Esanu, A., Braquet, R G., and Bazan, N. G., 1991, Recovery of postischemic brain metabolism and function following treatment with a free radical scavenger and platelet-activating factor antagonists, J. Neurochem. 56:311–319.

    Article  PubMed  CAS  Google Scholar 

  • Horrocks L. A., Harder, H., Nakagawa, Y., Yeo, Y., Birkle, D., and Bazan, N. G., 1985, Turnover of polyunsaturated fatty acids in different molecular species, Trans. Am. Soc. Neurochem. 16:154.

    Google Scholar 

  • Ikeda M. S., Yoshida, R., Busto, M., Santiso, M., and Ginsberg, M., 1986, Polyphosphoinositides as a probable source of brain free fatty acid accumulated at the onset of ischemia, J. Neurochem. 47: 123–132.

    Article  PubMed  CAS  Google Scholar 

  • Kass I. S., and Lipton, P., 1982, Mechanisms involved in irreversible anoxic damage to the in vivo rat hippocampal slice, J. Physiol. 332:459–472.

    PubMed  CAS  Google Scholar 

  • Marcheselli V. L., Rossowska, M., Domingo M. T., Braquet, P., and Bazan, N. G., 1990, Distinct platelet-activating factor binding sites in synaptic endings and in intracellular membranes of rat cerebral cortex, J. Biol. Chem. 265:9140–9145.

    PubMed  CAS  Google Scholar 

  • Panetta, T., Marcheselli V. L., Braquet, P., Spinnewyn, B., and Bazan, N. G., 1987, Effects of a platelet-activating factor antagonist (BN 52021) on free fatty acids, diacylglycerols, polyphosphoinositides and blood flow in the gerbil brain: Inhibition of ischemia-reperfusion induced cerebral injury, Biochem. Biophys. Res. Commun. 149:580–587.

    Article  PubMed  CAS  Google Scholar 

  • Rodriguez de Türco E. B., and Bazan, N. G., 1983, Changes in free fatty acids and diglycerides in mouse brain at birth and during anoxia, J. Neurochem. 41:794–800.

    Article  Google Scholar 

  • Rothman, S. M., 1983, Synaptic activity mediates death of hypoxic neurons, Science 220:536–537.

    Article  PubMed  CAS  Google Scholar 

  • Siesjö, B. K., Ingvar, M., and Westberg, A., 1982, The influences of bicuculline-induced seizures on free fatty acid concentration in cerebral cortex, hippocampus and cerebellum, J. Neurochem. 39: 796–802.

    Article  PubMed  Google Scholar 

  • Squinto, S. P., Block A. L., Braquet, P., and Bazan, N. G., 1989, Platelet-activating factor stimulates a Fos/Jun/AP-1 transcriptional signaling system in human neuroblastoma cells, J. Neurosci. Res. 24:558–566.

    Article  PubMed  CAS  Google Scholar 

  • Tao, Y., Allan, G., Bazan, H. E. P., Lin, N., and Bazan, N. G., 1990, Corneal wound healing triggers an increase in growth-associated protein (GAP-43) mRNA in the trigeminal ganglia, Suppl. Invest. Ophthalmol. Vis. Sci. 31:55.

    Google Scholar 

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Author information

Authors and Affiliations

  1. LSU Eye Center and Neuroscience Center, LSU Medical Center School of Medicine, New Orleans, Louisiana, USA

    Nicolas G. Bazan

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  1. Nicolas G. Bazan
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Editors and Affiliations

  1. LSU Eye Center and Neuroscience Center, Louisiana State University Medical Center School of Medicine, New Orleans, Louisiana, USA

    Nicolas G. Bazan

  2. Institut Henri Beaufour, 92350, Le Plessis Robinson, Paris, France

    Pierre Braquet

  3. Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Miami, Florida, USA

    Myron D. Ginsberg

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© 1992 Springer Science+Business Media New York

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Bazan, N.G. (1992). Modulators of Neural Cell Signaling and Triggering of Gene Expression following Cerebral Ischemia. In: Bazan, N.G., Braquet, P., Ginsberg, M.D. (eds) Neurochemical Correlates of Cerebral Ischemia. Advances in Neurochemistry, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3312-2_16

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  • DOI: https://doi.org/10.1007/978-1-4615-3312-2_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6458-0

  • Online ISBN: 978-1-4615-3312-2

  • eBook Packages: Springer Book Archive

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