Abstract
Virulence of disease-producing organisms is generally defined as the ability to produce a rapid course of infection or disease. Therefore, virulence of an organism can be considered to be its degree of disease-producing capacity.
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References
Biochemical aspects of microbial pathogenicity. Ann NY Acad Sci 88:1021–1318, 1960
Schaffner A, Davis CE, Schaffner T, et al: In vitro susceptibility of fungi to killing by neutrophil granulocytes discriminate between primary pathogenicity and opportunism. J Clin Invest 78:511–524, 1986
Brass C, Volkmann CM, Philpott DE, et al: Spontaneous mutant of Blastomyces dermatitidis attenuated in virulence. Sabouraudia 20:145–158, 1982
DiSalvo AF, Denton JF: Lipid content of four strains of Blastomyces dermatitidis of different mouse virulence. J Bacteriol 85:927–931, 1963
Levine RB, Pappagianis D, Cobb JM: Development of vaccines for coccidioidomycosis. Mycopathologia 41:171–185, 1970
Kumpel KR, Goldman WE: Isolation and characterization of spontaneous avirulent variants of Histoplasma capsulatum. Infect Immun 55:528–533, 1987
San Blas G, San Blas F, Serrano LE: Host-parasite relationship in the yeast-like form of Paracoccidioides brasiliensis strain IVIC Pb 9. Infect Immun 15:343–346, 1977
Kimpel KR, Goldman WE: Cell walls from avirulent variants of Histoplasma capsulatum lack alpha 1,3-glucan. Infect Immun 56:2997–3000, 1988
San Blas G, San Blas F: Variability of cell wall composition in Paracoccidioides brasiliensis: A study of two strains. Sabouraudia 20:31–40, 1982
Denton JF, McDonough ES, Ajello L, et al: Isolation of Blastomyces dermatitidis from soil. Science 133:1126–1127, 1961
Sarosi GA, Eckman MR, Davies SF, et al: Canine blastomycosis as a harbinger of human disease. Ann Intern Med 91:733–735, 1979
Baker RD: Tissue reactions in human blastomycosis: An analysis of tissue from twenty three cases. Am J Pathol 18:479–495, 1942
Gilchrist TCA: A case of blastomycosis in man. Johns Hopkins Hosp Rep 1:269–298, 1896
Williamson WM, Lombard LS, Getty RE: North American blastomycosis in a northern sea lion. J Am Vet Med Assoc 135:513–515, 1959
Denton JF, DiSalvo AF: Isolation of Blastomyces dermatitidis from natural sites at Augusta, Georgia. Am J Trop Med Hyg 13:716–722, 1964
Harvey RP, Schmid ES, Carrington CC, et al: Mouse model of pulmonary blastomycosis: Utility, simplicity, and quantitative parameters. Am Rev Respir Dis 117:695–703, 1978
Denton JF, DiSalvo AF: Respiratory infection of laboratory animals with conidia of Blastomyces dermatitidis. Mycopathol Mycol Appl 36:129–136, 1968
Williams JE, Moser SA: Chronic murine pulmonary blastomycosis induced by intratracheally inoculated Blastomyces dermatitidis conidia. Am Rev Respir Dis 135:17–25, 1987
Moser SA, Koker PJ, Williams JE: Fungal strain dependent alterations in the time course and mortality of chronic murine pulmonary blastomycosis. Infect Immun 56:34–39, 1988
McDade JE, Shephard CC: Virulent to avirulent conversion of Legionnaires’ disease bacterium (Legionella pneumophila): its effect on isolation techniques. J Infect Dis 139:707–711, 1979
Catrenich CE, Johnson W: Virulence conversion of Legionella pneumophila: A one-way phenomenon. Infect Immun 56:3121–3125, 1988
Brummer E, DiSalvo AF, Stevens DA: Virulence in Blastomyces dermatitidis: Influence of in vitro passage and storage methods, The XI Congress of ISHAM, Montreal, Program and Abstracts, p 169, 1991.
Morozumi PA, Brummer E, Stevens DA: Protection against pulmonary blastomycosis: Correlation with cellular and humoral immunity in mice after subcutaneous nonlethal infection. Infect Immun 37:670–678, 1982
Brummer E, Morozumi PA, Philpott DE, et al: Virulence of fungi: Correlation of virulence of Blastomyces dermatitidis in vivo with escape from macrophage inhibition of replication in vitro. Infect Immun 32:864–871, 1981
Brummer E, Morozumi PA, Stevens DA: Macrophages and fungi: In vitro effects of method of macrophage induction, activation by different stimuli, and soluble factors on Blastomyces. J Reticuloendothel Soc 28:507–518, 1980
Brummer E, Morrison CJ, Stevens DA: Recombinant and natural gamma-interferon activation of macrophages in vitro: Different dose requirements for induction of killing activity against phagocytizable and nonphagocytizable fungi. Infect Immun 49:724–730, 1985
Brummer E, Stevens DA: Activation of pulmonary macrophages for fungicidal activity by gamma-interferon or lymphokines. Clin Exp Immunol 70:520–528, 1987
Brummer E, Sugar AM, Stevens DA: Activation of peritoneal macrophages by concanavalin A or Mycobacterium bovis (BCG) for fungicidal activity against Blastomyces dermatitidis and effect of specific antibody and complement. Infect Immun 39:817–822, 1983
Brummer E, Stevens DA: Fungicidal mechanisms of activated macrophages: Evidence for nonoxidative mechanisms for killing Blastomyces dermatitidis. Infect Immun 55:3221–3224, 1987
Brummer E, Stevens DA: Opposite effects of human monocytes, macrophages, and polymorphonuclear neutrophils on replication of Blastomyces dermatitidis in vitro. Infect Immun 36:297–303, 1982
Drutz DJ, Frey CL: Intracellular and extracellular defences of human phagocytes against Blastomyces dermatitidis conidia and yeast. J Lab Clin Med 105:737–750, 1985
Brummer E, Stevens DA: Enhancing effect of murine polymorphonuclear neutrophils (PMN) on the multiplication of Blastomyces dermatitidis in vitro and in vivo. Clin Exp Immunol 54:587–594, 1983
Brummer E, Sugar AM, Stevens DA: Immunological activation of polymorphonuclear neutrophils for fungal killing: Studies with murine cells and Blastomyces dermatitidis in vitro. J Leukocyte Biol 36:505–520, 1984
Brummer E, Sugar AM, Stevens DA: Enhanced oxidative burst in immunologically activated but not elicited polymorphonuclear leukocytes correlates with fungicidal activity. Infect Immun 49:396–401, 1985
Brummer E, McEwen JG, Stevens DA: Fungicidal activity of murine inflammatory polymorphonuclear neutrophils: Comparison with murine peripheral blood PMN. Clin Exp Immunol 66:681–690, 1986
Sugar AM, Chahal RS, Brummer E, et al: Susceptibility of Blastomyces dermatitidis strains to products of oxidative metabolism. Infect Immun 41:908–912, 1983
Brass C, Volkman CM, Klein HP, et al: Pathogen factors and host factors in murine blastomycosis. Mycopathologia 78:129–140, 1982
Cox RA, Best GK: Cell wall composition of two strains of Blastomyces dermatitidis exhibiting differences in virulence in mice. Infect Immun 5:449–453, 1972
Kanetsuna F, Carbonell LM: Cell wall composition of the yeast-like and mycelial forms of Blastomyces dermatitidis. J Bacteriol 106:946–948, 1971
San Blas G, San Blas F:Paracoccidioides brasiliensis: Cell wall structure and virulence—A review.Mycopathologia 62:77–86, 1977
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© 1992 Springer Science+Business Media New York
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Brummer, E. (1992). Virulence of Blastomyces dermatitidis . In: Al-Doory, Y., DiSalvo, A.F. (eds) Blastomycosis. Current Topics in Infectious Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3306-1_3
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DOI: https://doi.org/10.1007/978-1-4615-3306-1_3
Publisher Name: Springer, Boston, MA
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