Abstract
Blastomyces dermatitidis is a dimorphic fungus, growing in the environment in a mycelial form and in mammalian tissue in a yeast form. In common with other dimorphic fungi, the life cycle of B. dermatitidis is not dependent upon entering a living host and establishing infection and disease. On the contrary, infection of living beings is an accidental occurrence. One corollary of this concept is that fungal dimorphism did not evolve as a response to survival at the higher temperatures of the infected animal. While ambient environmental temperatures (specifically in the soil) may fluctuate to reach those present in potential mammalian hosts, mean mammalian body temperatures most probably exceed those in the environment, although exact data on this point are not readily available. Therefore, there must be some other explanations for the evolution of fungal dimorphism, which presently remain unknown.
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References
Gilchrist TC, Stokes WR: The presence of an oidium in the tissues of a case of pseudo-lupus vulgaris. Johns Hopkins Hosp Bull 7:129–133, 1896
McDonough ES, Lewis AL: Blastomyces dermatitidis: Production of the sexual stage. Science 156:528–529, 1967
Maresca B, Kobayashi GS: Dimorphism in Histoplasma capsulatum: A model for the study of cell differentiation in pathogenic fungi. Microbiol Rev 53:186–209, 1989
Szaniszlo PJ, Jacobs CW, Geis PA: Dimorphism: Morphological and biochemical aspects, in Howard DH, Howard LF (eds): Fungi Pathogenic for Humans and Animals. New York, Marcel Dekker, 1983, p 323
SanBlas G, SanBlas F: Molecular aspects of fungal dimorphism. CRC Crit Rev Microbiol 11:101–127, 1984
Gilardi GL, Laffer NC: Nutritional studies on the yeast phase of Blastomyces dermatitidis and B. brasiliensis. J Bacteriol 83:219–227, 1962
Griffin DH: Fungal Physiology. New York, John Wiley & Sons, 1981
Matsumoto K, Uno I, Ishikawa T: Genetic analysis of the role of cAMP in yeast. Yeast 1:15–24, 1985
Cole GT: Models of cell differentiation in conidial fungi. Microbiol Rev 50:95–132, 1986
Kukuruzinska MA, Bergh MLE, Jackson BJ: Protein glycosylation in yeast. Annu Rev Biochem 56:915–944, 1987
Nasmyth K, Shore D: Transcriptional regulation in the yeast life cycle. Science 237:1162–1170,1987
Jennings DH: Translocation of solutes in fungi. Biol Rev 62:215–243, 1987
Guarente L: Regulatory proteins in yeast. Annu Rev Genet 21:425–452, 1987
Domer JE: Blastomyces dermatitidis in Szaniszlo PJ (ed): Current Topics in Infectious Disease: Fungal Dimorphism New York, Plenum Press, 1985, p 51
Rippon JW: Blastomycosis, in Medical Mycology. The Pathogenic Fungi and the Pathogenic Actinomycetes, ed 3. Philadelphia, WB Saunders, 1988, p 474
Vermeil C, Bouillard C, Miegeville M, et al: The echinulate conidia of Blastomyces dermatitidis Gilchrist and Stokes and the taxonomic status of this species. Mykosen 25:251–253, 1982
Rippon JW, Ajello LA, Maraganore M, et al: Small form blastomycosis mimicking histoplasmosis. Abstracts of the Annual Meeting of the American Society for Microbiology 1986:F-44
McDonough ES, Lewis AL: The ascigerous stage of Blastomyces dermatitidis. Mycologia 60:76–83, 1968
Currah RS: Taxonomy of the Onygenales: Arthrodermataceae, Gymnoascaceae, Myxotrichaceae, and Onygenaceae Mycotaxon 24:1–216, 1985
Kwon-Chung KJ: Studies on Emmonsiella capsulata 1. Heterothallism and development of the ascocarp. Mycologia 65:109–121, 1973
Glick AD, Kwon-Chung KJ: Ultrastructural comparison of coils and ascospores of Emmonsiella capsulata and Ajellomyces dermatitidis. Mycologia 65:216–221, 1973
McGinnis MR, Katz B: Ajellomyces and its synonym Emmonsiella. Mycotaxon 8:157–164, 1979
Levine S, Ordal ZJ: Factors influencing the morphology of Blastomyces dermatitidis. J Bacteriol 52:687–694, 1946
Gilardi GL: Nutrition of systematic and subcutaneous pathogenic fungi Bacteriol Rev 29:406–424, 1965
Salvin SB: Phase-determining factors in Blastomyces dermatitidis. Mycologia 41:311–319, 1949
Domer JE: Monosaccharide and chitin content of cell walls of Histoplasma capsulatum and Blastomyces dermatitidis. J Bacteriol 107:870–877, 1971
Clemons KV, Hurley S, Treat-Clemons LG, et al: Variable colonial phenotypic expression of Blastomyces dermatitidis (Bd). Abstracts of the Annual Meeting of the American Society for Microbiology 1989:F-43
Kaufman L, Standard PG, Weeks RJ, et al: Detection of two Blastomyces dermatitidis serotypes by exoantigen analysis. J Clin Microbiol 18:110–114, 1983
Zaharee MH, Wilson TE, Scheer ER: The effect of growth media upon the ultrastructure of Blastomyces dermatitidis. Can J Microbiol 28:211–218, 1982
Garrison RG, Lane JW, Field MF: Ultrastructural changes during the yeastlike to mycelialphase conversion of Blastomyces dermatitidis and Histoplasma capsulatum. J Bacteriol 101:628–635,1970
Bawdon RE, Fiskin AM, Garrison RG: Ultrastructural aspects of cytoplasmic ribosomes from Histoplasma capsulatum and Blastomyces dermatitidis as revealed by heavy metal staining. Mycopathologia 86:155–163, 1984
DeLamater ED: The nuclear cytology of Blastomyces dermatitidis. Mycologia 40:430–445, 1948
Edwards GA, Edwards MR: The intracellular membranes of Blastomyces dermatitidis. Am J Bot 47:622–632, 1960
Kwon-Chung KJ: Genetic analysis on the incompatibility system of Ajellomyces dermatitidis. Sabouraudia 9:231–238,1971
Halliday WJ, McCoy E: Biotin as a growth requirement for Blastomyces dermatitidis. J Bacteriol 70:464–468, 1955
Levine S, Ordal ZJ: Factors influencing the morphology of Blastomyces dermatitidis. J Bacteriol 52:687–694, 1946
Sheiban ZB: Morphological conversion of Blastomyces dermatitidis in tapwater. Bull. WHO 51:423, 1974
Kanetsuna F, Carbonell LM: Cell wall composition of the yeastlike and mycelial forms of Blastomyces dermatitidis. J Bacteriol 106:946–948,1971
Roy I, Landau JW: Composition of the alkali resistant cell wall material of dimorphic Blastomyces dermatitidis. Sabouraudia 10:107–112, 1972
Lancaster MV, Sprouse RF: Isolation of a purified skin test antigen from Blastomyces dermatitidis yeast-phase cell wall. Infect Immun 14:623–625, 1976
Deighton F, Cox RA, Hall NK, et al: In vivo and in vitro cell-mediated immune responses to a cell wall antigen of Blastomyces dermatitidis. Infect Immun 15:429–435, 1977
Hall NK, Deighton F, Larsh HW: Use of an alkali-soluble water-soluble extract of Blastomyces dermatitidis yeast-phase cell walls and isoelectrically focused components in peripheral lymphocyte transformations. Infect Immun 19:411–415, 1978
Roy I, Landau JW: Protein constituents of cell walls of the dimorphic phases of Blastomyces dermatitidis. Can J Microbiol 18:473–478, 1972
Peck RL, Hauser CR: Chemical studies of certain pathogenic fungi. I. The lipids of Blastomyces dermatitidis. J Am Chem Soc 60:2599–2603, 1938
DiSalvo AF, Denton JF: Lipid content of four strains of Blastomyces dermatitidis of different mouse virulence. J Bacteriol 85:927–931, 1963
Domer JE, Hamilton JG: The readily extracted lipids of Histoplasma capsulatum and Blastomyces dermatitidis. Biochim Biophys Acta 231:465–478, 1971
Massoudnia A, Scheer ER: The influence of medium on the chemical composition of Blastomyces dermatitidis. Curr Microbiol 7:25–28, 1982
Brass C, Volkmann CM, Philpott DE, et al: Spontaneous mutant of Blastomyces dermatitidis attenuated in virulence for mice. Sabouraudia 20:145–158, 1982
Kanetsuna F, Carbonell LM, Azuma I, et al: Biochemical studies on the thermal dimorphism of Paracoccidioides brasiliensis.J Bacteriol 110:208–218, 1972
Gow NAR, Gooday GW: Ultrastructure of chitin in hyphae of Candida albicans and other dimorphic and mycelial fungi Protoplasma 115:52–58, 1983
Klein BS, Jones JM: Isolation, purification, and radiolabelling of a novel 120-kD surface protein on Blastomyces dermatitidis yeasts to detect antibody in infected patients. J Clin Invest 85:152–161, 1990
Young KD, Larsh HW: Antigens and chemical composition of Blastomyces dermatitidis Mycopathologia 78:47–63, 1982
Taylor JJ: Nucleic acids and dimorphism in Blastomyces. Exp Cell Res 24:155–158, 1961
Bawdon RE, Garrison RG, Fina LR: Deoxyribonucleic acid base composition of the yeast-like and mycelial phases of Histoplasma capsulatum and Blastomyces dermatitidis. J Bacteriol 111:593–596, 1972
Medoff G, Painter A, Kobayashi GS: Mycelial-to yeast-phase transitions of the dimorphic fungi Blastomyces dermatitidis and Paracoccidioides brasiliensis. J Bacteriol 169:4055–4060, 1987
Rippon JW: Blastomycosis, in Medical Mycology: The Pathogenic Fungi and the Pathogenic Actinomycetes, ed 3. Philadelphia, WB Saunders, 1988, pp 499–500
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Sugar, A.M. (1992). Taxonomy and Biology of Blastomyces dermatitidis . In: Al-Doory, Y., DiSalvo, A.F. (eds) Blastomycosis. Current Topics in Infectious Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3306-1_2
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DOI: https://doi.org/10.1007/978-1-4615-3306-1_2
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