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Basic fibroblast growth factor in cardiac myocytes: expression and effects

  • Chapter
Book cover Growth Factors and the Cardiovascular System

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 147))

Abstract

Ventricular myocytes of the adult mammalian myocardium are considered essentially incapable of regeneration. These cells cease dividing soon after birth and subsequent cardiac growth is brought about by increases in cellular size (hypertrophy) rather than cell number [1]. Following irreversible injury and death of cardiomyocytes, caused by a variety of factors such as ischemia, excess catecholamines or genetic defects, necrotic muscle becomes replaced by scar tissue. The remaining myocardium hypertrophies to meet the need for extra work but beyond a certain potential for adaptation, cardiac failure ensues. There is some evidence that ventricular myocytes may not have lost their proliferative potential irreversibly, since they can be stimulated to synthesize DNA in culture [2] and are apparently capable of a hyperplastic response in hypertrophie or ageing hearts [3].

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Authors
  1. Elissavet Kardami
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  2. Raymond R. Padua
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  3. Kishore Babu S. Pasumarthi
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  4. Lei Liu
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  5. Bradley W. Doble
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  6. Sarah E. Davey
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  7. Peter A. Cattini
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Editor information

Editors and Affiliations

  1. Department of Physiology, University of Birmingham School of Medicine, Birmingham, UK

    Peter Cummins

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© 1993 Springer Science+Business Media New York

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Kardami, E. et al. (1993). Basic fibroblast growth factor in cardiac myocytes: expression and effects. In: Cummins, P. (eds) Growth Factors and the Cardiovascular System. Developments in Cardiovascular Medicine, vol 147. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3098-5_5

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  • DOI: https://doi.org/10.1007/978-1-4615-3098-5_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6354-5

  • Online ISBN: 978-1-4615-3098-5

  • eBook Packages: Springer Book Archive

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