Abstract
Repeated transfusions of platelet concentrates (PC) lead to alloimmunization and platelet refractoriness was subsequently observed in about 40% of recipients [1]. Contaminating leukocytes in platelet concentrates are known to play an essential role in alloimmunization. Prevention of alloimmunization by reducing the number of leukocytes contaminating PC has been achieved using leukocyte removing filters with encouraging results [2]. However, introduction of leukocyte removing filters into clinical transfusion meets with some problems such as complexity in filtration procedures, increase in cost, and loss of platelets during filtration.
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References
Yankee RA, Grumet FC, Roquentine GN. Platelet transfusion therapy. The selection of compatible platelet donors for refractory patients by lymphocyte HLA typing. N Engl J Med 1969;281:1208–12.
Andreu G, Dewailly J, Leberre C, et al. Prevention of HLA immunization with leukocyte-poor packed red cells and platelet concentrates obtained by filtration. Blood 1988;72:964–9.
Slichter SJ, Deeg HJ, Kennedy M. Prevention of platelet alloimmunization in dogs with systemic cyclosporin and by UV-irradiation of cyclosporin-loading of donor platelets. Blood 1987;69:414–8.
Andreu G, Boccaccio C, Lecrubier C, et al. Ultraviolet irradiation of platelet concentrates: Feasibility in transfusion practice. Transfusion 1990:30:401–6.
Pamphilon DH, Alnagdy AA, Wallington TB. Immunology by ultraviolet light: Clinical studies and biological effects. Immunol Today 1991; 12:119–23.
Slichter SJ. UV irradiation. Effects on the immune system and on platelet function, viability, and alloimmunization. In: Smit Sibinga CTh, Kater L (eds). Advances in haemapheresis. Kluwer Academic Publishers, Dordrecht 1992:207–28.
Aberer WG, Schuler G, Stingl G, Hönigsmann H, Wolff K. Ultraviolet light depletes surface markers of Langerhans cells. J Invest Dermatol 1981;76:202–10.
Krutmann J, Khan IU, Wallis RS, et al. Cell membrane is a major locus for ultraviolet B-induced alterations in accessory cells. J Clin Invest 1991;85:1529–36.
Jakway JP, Shevach EM. Stimulation of T-cell activation by UV-treated, antigen-pulsed macrophages: Evidence for a requirement for antigen processing and interleukin-1 secretion. Cell immunol 1983;80:151–62.
Lange-Wantzin G, Rothlein R, Kahn J, Faanes RB. Effect of UV irradiation on expression of membrane IL-1 by rat macrophages. J Immunol 1987;138:3803–7.
Spielberg H, June CH, Blair OC, Nystrom-Rosander C, Cereb N, Deeg HJ. UV irradiation of lymphocytes triggers an increase in intracellular Ca2+ and prevents lectin stimulated Ca2+ mobilization: Evidence for UV-and Nifedipine-sensitive Ca2+ channels. Exp Hematol 1991;19:742–8.
Hertl M, Kaplan DR, Fayen JD, Panuska JR, Ellner JJ, Elmets CA. The accessory function of B lymphocytes is resistant to the adverse effects of UV radiation. Eur J Immunol 1991;21:291–7.
Takahashi T, Hirsh A, Erbe E, Williams RJ. Mechanism of cryoprotection by extracellular polymeric solutions. Biophys J 1988;54:509–18.
Sekiguchi S, Takahashi TA, Yamamoto S, et al. A new type of blood component collector: Plasma separation using gravity without any electrical devices. Vox Sang 1990;58:182–7.
Babior BM, Kipnes RS, Curnutt JJ. Biological defense mechanisms. The production by leukocytes of Superoxide, a potential bactericidal agent. J Clin Invest 1973;52: 741–4.
Miyazawa T, Yasuda K, Gujimoto K, Kaneda T. Presence of phosphatidylcholine hydroperoxide in human plasma. J Biochem 1988;103:744–6.
Punnonen K, A P, Ahotupa M. Effects of ultraviolet A and B irradiation on lipid peroxidation and activity of the antioxidant enzymes in keratinocytes in culture. Photodermal Photoimmunol Photomed 1991;7:173–7.
Thomas PD, Poznasky MJ. A modified tetramethylbenzidine method for measuring lipid hydroperoxides. Anal Biochem 1990;188:228–32.
Andreu G, Boccaccio C, Klaren J, et al. The role of UV radiation in the prevention of human leukocyte antigen alloimmunization. Transf Med Rev 1992;3:212–24.
Deeg HJ. Ultraviolet irradiation in transplantation biology: Manipulation of immunity and immunogenicity. Transplantation 1988;45:845–51.
Peak JG, Peak MJ, MacCoss M. DNA breakage caused by 334-nm ultraviolet light is enhanced by naturally occurring nucleic acid components and nucleotide coenzymes. Photochem Photobiol 1984;39:713–6.
Anderson RE, Standefer JC, Scaletti JV. Radiosensitivity of defined populations of lymphocytes. Cell Immunol 1977;33:45–61.
Linden JV, Pisciotto PT. Transfusion-associated graft-versus-host disease and blood irradiation. Transf Med Rev 1992;2:116–23.
Valerius NH, Johansen KS, Nielson OS, Platz P, Rosenkvist J, S0rensen H. Effect of in vitro X-irradiation on lymphocyte and granulocyte function. Scand J Haematol 1981;27:9–18.
Gabbiani G, Chaponnier C, Zumbe A, Vassalli P. Actin and tubulin co-cap with surface immunoglobulines in mouse B lymphocytes. Nature 1977;269:697–8.
Nelson WJ, Colaco CA, Lazarides E. Involvement of spectrin in cell-surface receptor capping in lymphocytes. Proc Natl Acad Sci USA 1983;80:1626–30.
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Takahashi, T.A. et al. (1993). Potential Involvement of Free Radical Reactions in Inactivating Antigen Presenting Cells by Ultraviolet-B Irradiation. In: Sibinga, C.T.S., Das, P.C., The, T.H. (eds) Immunology and Blood Transfusion. Developments in Hematology and Immunology, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3094-7_3
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DOI: https://doi.org/10.1007/978-1-4615-3094-7_3
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