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Heart Function in Health and Disease pp 79–90Cite as

Phospholipase D: A New Avenue to the Phospholipid Signalling Pathways in the Myocardium

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 140))

Abstract

Over the past decade it has become known that phospholipids, present in the plasma membrane, play an essential part in receptor signal transduction. Firstly, changes in plasma membrane phospholipid composition alter the physicochemical properties of the lipid bilayer and the lipid domains of membrane proteins (receptors, ion channels, enzymes etc.), thereby influencing cell function [1]. Secondly, phospholipids originate several intracellular messenger molecules [2–5]. These phospholipid metabolites may stem from the headgroup, such as inositol 1,4,5-trisphosphate (Ins(l,4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (Ins(l,3,4,5)P4), or they may be of a lipid nature, such as certain non-esterified fatty acids (NEFAs), lysophospholipids (lysoPLs), sn-l,2-diacylglycerol (DAG), phosphatidic acid (PtdOH) and eicosanoids. The presence of the enzymes responsible for the formation of above mentioned metabolites in myocardial cells has in most cases been confirmed only recently [6–9]. Moreover, with regard to the knowledge on the mechanisms of stimulus-response coupling through phospholipid pathways, only a corner of the veil has been lifted.

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Author information

Authors and Affiliations

  1. Division of Cardiovascular Sciences, St. Boniface General Hospital Research Centre and Department of Anatomy, University of Manitoba, Winnipeg, Manitoba, Canada

    J. T. A. Meij & V. Panagia

Authors
  1. J. T. A. Meij
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  2. V. Panagia
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Editor information

Editors and Affiliations

  1. Institute of Physiology, Czechoslovak Academy of Sciences, Prague, Czechoslovakia

    Bohuslav Ostadal (Director) (Director)

  2. Division of Cardiovascular Sciences, St. Boniface General Hospital Research Centre University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla (Distinguished Professor and Head) (Distinguished Professor and Head)

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© 1993 Springer Science+Business Media New York

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Meij, J.T.A., Panagia, V. (1993). Phospholipase D: A New Avenue to the Phospholipid Signalling Pathways in the Myocardium. In: Ostadal, B., Dhalla, N.S. (eds) Heart Function in Health and Disease. Developments in Cardiovascular Medicine, vol 140. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3090-9_7

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  • DOI: https://doi.org/10.1007/978-1-4615-3090-9_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6350-7

  • Online ISBN: 978-1-4615-3090-9

  • eBook Packages: Springer Book Archive

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