Abstract
Experimental data clearly indicate that significant ontogenetic differences exist in cardiovascular sensitivity to inotropic agents, both under “in vitro” and “in vivo” conditions (1). It seems likely that despite significant interspecies differences developmental changes may exist in all mammals depending on the degree of maturation of systems involved in the regulation of contractile function (2). This field of investigation was stimulated in recent years by an increasing clinical use of positive and negative inotropic drugs (e.g. catecholamines, calcium antagonists) during early phases of ontogenetic development, particularly during pregnancy in order to prevent premature labor or to treat acute intrapartum fetal distress (3, 4) or in pediatric cardiology (5, 6).
Keywords
- Sarcoplasmic Reticulum
- Ontogenetic Development
- Postnatal Development
- Cardiac Contractile Function
- Ontogenetic Difference
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Ostádal, B., Kolár, F., Skovránek, J., Ostádalová, I. (1993). Ontogenetic Development of Cardiac Inotropic Responsiveness. In: Ostadal, B., Dhalla, N.S. (eds) Heart Function in Health and Disease. Developments in Cardiovascular Medicine, vol 140. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3090-9_3
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DOI: https://doi.org/10.1007/978-1-4615-3090-9_3
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