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Fos and Jun: Inducible transcription factors regulating growth of normal and transformed cells

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Oncogenes and Tumor Suppressor Genes in Human Malignancies

Part of the book series: Cancer Treatment and Research ((CTAR,volume 63))

Abstract

Although the study of oncogenes has provided some useful insights into cancer mechanisms, the most important benefit from oncogene research has been the delineation of the growth factor response pathway and molecular characterization of important cellular processes. The nuclear proto-oncogenes c-fos and c-jun have been particularly useful in this regard. Their study has provided important information about gene regulation in response to growth factors, regulation of immediate early genes, and the function and interaction of transcription factors. This chapter will describe (1) the expression and function of these cellular proto-oncogenes as ’immediate early’ genes, (2) interactions between Fos, Jun, and other transcription factors, (3) distinct transcriptional effects of Fos, and (4) how mutation and/or overexpression of these oncogenes alters their transcriptional effects and carcinogenic potential, and (5) the potential role of these proteins in human tumorigenesis.

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Authors
  1. Jeffrey Holt
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Editors and Affiliations

  1. Cancer Research Institute, University of California, San Francisco, USA

    Christopher C. Benz

  2. Lineberger Cancer Research Center, The University of North Carolina at Chapel Hill, USA

    Edison T. Liu

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Holt, J. (1993). Fos and Jun: Inducible transcription factors regulating growth of normal and transformed cells. In: Benz, C.C., Liu, E.T. (eds) Oncogenes and Tumor Suppressor Genes in Human Malignancies. Cancer Treatment and Research, vol 63. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3088-6_15

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  • DOI: https://doi.org/10.1007/978-1-4615-3088-6_15

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