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Uses of polymerase chain reaction in leukemia: Detection of minimal residual disease and identification of novel genetic mutations

  • Ming-Sheng Lee
  • Sanford A. Stass
Part of the Cancer Treatment and Research book series (CTAR, volume 64)

Abstract

Polymerase chain reaction (PCR) is a new molecular technique that allows in vitro amplification up to millions of copies of the target DNA [1]. It was initially used to facilitate the specific identification of hereditary genetic disorders with a point mutation. Its clinical usefulness is overtly evident, because it requires only very small amounts of samples and also because the whole assay can be completed within a very short period of time (ranging from a few hours to a couple of days).

Keywords

Polymerase Chain Reaction Chronic Myeloid Leukemia Polymerase Chain Reaction Assay Chronic Myelogenous Leukemia Minimal Residual Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Ming-Sheng Lee
  • Sanford A. Stass

There are no affiliations available

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