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Multidrug resistance in leukemia

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Leukemia: Advances in Research and Treatment

Part of the book series: Cancer Treatment and Research ((CTAR,volume 64))

Abstract

Over the last 20 years, advances in chemotherapy have improved the outcome in a number of cancers, most notably in the acute leukemias, lymphomas, testicular carcinoma, and several pediatric malignancies. Despite the advances in the treatment of the acute leukemias with very high remission rates to initial chemotherapy and significant cure rates, many patients will relapse and eventually become resistant to further chemotherapy [1,2]. Although several factors may contribute to the failure of chemotherapy, it is thought that a major obstacle is the development of drug resistance at the cellular level.

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Authors
  1. Danny Rischin
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  2. Victor Ling
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  1. M.D. Anderson Cancer Center, The University of Texas, USA

    Emil J. Freireich  & Hagop Kantarjian  & 

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Rischin, D., Ling, V. (1993). Multidrug resistance in leukemia. In: Freireich, E.J., Kantarjian, H. (eds) Leukemia: Advances in Research and Treatment. Cancer Treatment and Research, vol 64. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3086-2_13

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