Monoclonal antibodies in the treatment of myelogenous leukemias

  • David A. Scheinberg
Part of the Cancer Treatment and Research book series (CTAR, volume 64)


Monoclonal antibodies (mAb) differ dramatically from conventional therapeutic agents in their mechanisms of actions and in their biochemical and biological properties [1–3]. On the one hand, mAbs are capable of selective targeting of tumor cells while avoiding normal tissues. MAbs are able to kill tumor cells via a variety of intrinsic (immunological) and extrinsic (by use of carried cytotoxic agents) modes. On the other hand, these molecules are large, poorly diffusible into areas of bulky disease, and highly immunogenic, rendering repeated infusions difficult. These advantages and disadvantages must be carefully considered in the application of mAb to the treatment of hematopoietic cancers.


Acute Myelogenous Leukemia Linear Energy Transfer Autologous Bone Marrow Transplantation Acute Myelogenous Leukemia Cell Rabbit Complement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 1993

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  • David A. Scheinberg

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