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Transplant immunosuppression-related malignant lymphomas

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Malignant lymphomas, including Hodgkin’s disease: Diagnosis, management, and special problems

Part of the book series: Cancer Treatment and Research ((CTAR,volume 66))

Abstract

First recognized in 1968, the occurrence of abnormal lymphoproliferations following organ transplantation is a now a well-recognized but still frequently fatal complication of immunosuppression [1, 2]. Variously referred to as post-transplantation lymphoproliferative disorder (PTLD) or B-lymphoproliferative disorder (B-LPD), the terms describe a spectrum of Epstein-Barr virus associated B-lymphoproliferations occurring after transplantation; strikingly similar lymphoproliferative disorders have been described in congenital and other acquired immunodeficiency states. The disease has assumed increasing clinical significance in view of the constantly rising number of organ transplant recipients, the development of progressively more potent and specific immunosuppressive drugs, and the growing number of AIDS patients now surviving for prolonged periods in the face of profound immunodeficiency. Once established, B-LPD is often morphologically indistinguishable from aggressive non-Hodgkin’s lymphoma. The pathogenesis, presentation, clinical course, and management of B-LPD nevertheless differ significantly from those of classic non-Hodgkin’s lymphoma. The disease continues to provide insights into the nature of lymphoid malignancy in general, and new approaches to treatment are showing encouraging early results.

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  1. Lode J. Swinnen
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Editors and Affiliations

  1. Oregon Health Sciences University, USA

    Bruce W. Dana (Clinical Associate Professor of Medicine, Member) (Clinical Associate Professor of Medicine, Member)

  2. The Hematology Clinic Portland, Oregon, USA

    Bruce W. Dana (Clinical Associate Professor of Medicine, Member) (Clinical Associate Professor of Medicine, Member)

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Swinnen, L.J. (1993). Transplant immunosuppression-related malignant lymphomas. In: Dana, B.W. (eds) Malignant lymphomas, including Hodgkin’s disease: Diagnosis, management, and special problems. Cancer Treatment and Research, vol 66. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3084-8_7

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  • DOI: https://doi.org/10.1007/978-1-4615-3084-8_7

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