Abstract
The traditional approach to extremity sarcomas was surgical excision. This was associated with a local failure rate of approximately 95% [1], as tumors were simply ‘shelled out’ of their pseudocapsule. More radical muscle group and compartment excisions were then performed that reduced the local failure to approximately 40% [2]. Even with amputation, local failure was approximately 35%. Without effective additional therapy to control microscopic residual disease, radical surgery alone resulted in both poor functional results and high recurrence rates.
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Engel, C.J., Eilber, F.R., Rosen, G., Selch, M.T., Fu, YS. (1993). Preoperative chemotherapy for soft tissue sarcomas of the extremities: The experience at the University of California, Los Angeles. In: Verweij, J., Pinedo, H.M., Suit, H.D. (eds) Multidisciplinary Treatment of Soft Tissue Sarcomas. Cancer Treatment and Research, vol 67. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3082-4_9
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DOI: https://doi.org/10.1007/978-1-4615-3082-4_9
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