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Cardiac Contractile Proteins and Autoimmune Myocarditis

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Cellular Function and Metabolism

Part of the book series: Developments in Molecular and Cellular Biochemistry ((DMCB,volume 9))

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Abstract

Concerning cardiac contractile proteins, antigenicity and myocarditogenicity were discussed. In normal states, these proteins are immunologically tolerant, and can not provoke any heart-specific disease. Why the proteins can provoke such lethal autoimmune myocarditis has not been completely elucidated. Shortly after cardiac infection or myocardial ischemia, these proteins may work as the antigen for the autoimmune myocardites. First of all, the role of cardiac myosin has been strongly emphasized. But, the antigen determinants: epitope proteins remain unclear. Either cross-activity to the streptococcal M protein and/or the α-helical coiled-coil protein may be an important factor to determine antigenicity. In this autoimmune myocarditis, the roles of T-lymphocyte and cardiac dendritic cell are noticeable. Through further study on the relation between antigen epitope and the infectious agents in the heart; on cardio-cytotoxity of the T-lymphocyte and on the precise contribution of cardiac dendritic cells, this autoimmune myocarditis will be more clarified. (Mol Cell Biochem 119: 67–71, 1993)

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Authors and Affiliations

  1. First Department of Internal Medicine, Niigata University School of Medicine, Niigata, 951, Japan

    Tohru Izumi, Haruo Hanawa, Makihiko Saeki & Makoto Kodama

  2. First Department of Internal Medicine, Niigata University School of Medicine, Niigata, Japan

    Tohru Izumi

Authors
  1. Tohru Izumi
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  2. Haruo Hanawa
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  3. Makihiko Saeki
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  4. Makoto Kodama
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Editors and Affiliations

  1. Third Department of Internal Medicine Faculty of Medicine, University of Tokyo, Bunkyo-ku, Hongo 7-3-1, Tokyo 113, Japan

    Yoshio Yazaki (Professor of Medicine) (Professor of Medicine)

  2. Department of Internal Medicine, Jikei University School of Medicine, Katsushika-ku, Aoto 6-41-2, Tokyo 125, Japan

    Seibu Mochizuki (Professor of Medicine) (Professor of Medicine)

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© 1993 Springer Science+Business Media Dordrecht

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Izumi, T., Hanawa, H., Saeki, M., Kodama, M. (1993). Cardiac Contractile Proteins and Autoimmune Myocarditis. In: Yazaki, Y., Mochizuki, S. (eds) Cellular Function and Metabolism. Developments in Molecular and Cellular Biochemistry, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3078-7_10

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  • DOI: https://doi.org/10.1007/978-1-4615-3078-7_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6344-6

  • Online ISBN: 978-1-4615-3078-7

  • eBook Packages: Springer Book Archive

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