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Taurine Effects on Ion Channels of Cardiac Muscle

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Ionic Channels and Effect of Taurine on the Heart

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 141))

Abstract

Taurine exerted a protective effect against the decline in the Ca2+- dependent slow action potentials (APs) caused by hypoxia (Sawamura et al., 1986a), but did not induce Ca2+-dependent slow APs (Sawamura et al., 1986b) and did not elevate cAMP level (Sawamura et al., 1983). Taurine also exerted a positive inotropic effect (in perfused embryonic (20-day-old) chick heart) without affecting the slow APs, and it was suggested that the positive inotropic effect was not mediated through an increase in slow Ca2+ current (Sawamura et al., 1986b). The effects of taurine on the Ca2+ slow current in guinea pig myocytes depended on the external Ca2+ concentration (Sawamura et al., 1990).

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References

  • Azari J, Brumbaugh P & Huxtable R (1980). Prophylaxis by taurine in the hearts of cardiomyopathic hamsters. J Mol Cell Cardiol 12, 1353–1366.

    Article  PubMed  CAS  Google Scholar 

  • Azuma J, Sawamura A & Awata K (1985). Therapeutic effect of taurine in congestive heart failure. A double-blind cross-over trial. Clin Cardiol 8, 276–282.

    Article  PubMed  CAS  Google Scholar 

  • Azuma J, Takihara K, Awata N, Ohta H, Sawamura A, Harada H & Kishimoto S (1984). Beneficial effect of taurine on congestive heart failure induced by chronic aortic regurgitation in rabbits. Res Commun Chem Pathol Pharmacol 45, 261–270.

    PubMed  CAS  Google Scholar 

  • Baskin SI & Finney CM (1979). Effects of taurine and taurine analogue on the cardiovascular system. Garnyu Aminosan (Sulfur-containing Amino Acids) 2, 1–18.

    CAS  Google Scholar 

  • Bigger JT & Mandel WJ (1970). Effect of lidocaine on the electrophysiological properties of ventricular muscle and Purkinje fibers. J Clin Invest 46, 63–77.

    Article  Google Scholar 

  • Bigger JT, Basset AL & Hoffman BF (1968). Electrophysiological effects of diphenylhydantoin on canine Purkinje fibers. Circ Res 22, 221–236.

    Article  PubMed  CAS  Google Scholar 

  • Bkaily G & Sperelakis N (1984). Injection of protein kinase inhibitor into cultured heart cells blocks calcium slow channels. Am J Physiol 246, H630–H634.

    PubMed  CAS  Google Scholar 

  • Dietrich J & Diácono J (1971). Comparison between ouabain and taurine effects on isolated rat and guinea-pig hearts in low calcium medium. Life Sci 10, 499–507.

    Article  CAS  Google Scholar 

  • Dolara P, Ledda F, Mugelli A, Mantelli L, Zilletti L, Franconi F & Giotti A (1978). Effect of taurine on calcium, inotropsim, and electrical activity of the heart. In: Barbeau A & Huxtable RJ(Ed) Taurine and Neurological Disorders. Raven Press, New York, pp. 151–159.

    Google Scholar 

  • Dumaine R & Schanne OF (1991). Depression of INa by taurine in isolated rabbit cardiac myocytes. Biophys J 59, 739 (abst).

    Google Scholar 

  • Fabiato A & Fabiato F (1979). Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. J Physiol 75, 463–505.

    CAS  Google Scholar 

  • Franconi F, Martini F, Stendari I, Matucci R, Zilleti L & Giotti A (1982). Effect of taurine on calcium level and contractility in guinea-pig ventricular strips. Biochem Pharmacol 31, 3181–3186.

    Article  PubMed  CAS  Google Scholar 

  • Hamill OP, Marty A, Neher E, Sakmann B & Sigworth J (1981). Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 391, 88–100.

    Article  Google Scholar 

  • Huxtable RJ & Sebring LA (1980). Towards a unifying theory for the actions of taurine. Trends Pharmacol Sci 7, 481–485.

    Article  Google Scholar 

  • Kojima M & Sperelakis N (1984). Properties of oscillatory after-potentials in young embryonic chick hearts, Circ Res 55, 497–503.

    Article  PubMed  CAS  Google Scholar 

  • Kramer JH, Chooan JP & Schaffer SW (1981). Effect of taurine on calcium paradox and ischemic heart failure. Am J Physiol 240, H238–H246.

    PubMed  CAS  Google Scholar 

  • Kuriyama K, Hashimoto T, Kimori M, Nakamura Y & Yamamoto S (1989). Taurine and receptor mechanisms in the heart: Possible correlates with the occurrence of ischemic myocardial damages. In: Iwata H, Lombardini JB & Segawa T(Ed) Taurine and the Heart. Kluwer Academic Publishers, Boston, pp. 139–158.

    Chapter  Google Scholar 

  • Li T & Sperelakis N (1983). Stimulation of slow action potentials in guinea pig papillary muscle cells by intracellular injection of cAMP, Gpp(NH)p, and cholera toxin. Circ Res 52, 111–117.

    Article  PubMed  CAS  Google Scholar 

  • Lombardini JB (1980). Effect of ischemia on taurine levels. In: Cavallini D, Gaull GE & Zappia V(Ed) Natural Sulfur Compounds. Plenum Press, New York, pp. 255–306.

    Google Scholar 

  • McBroom MJ & Welty JD (1977). Effects of taurine on heart calcium in the cardiomyopathic hamster. J Mol Cell Cardiol 9, 853–858.

    Article  PubMed  CAS  Google Scholar 

  • Satoh H & Sperelakis N (1991a). Actions of taurine on fast Na+ current(INa) in embryonic chick ventricular myocytes. Faseb J 5(6), A1742.

    Google Scholar 

  • Satoh H & Sperelakis N (1991b)Identification of the hyperpolarization-activated inward current in young embryonic chick heart myocytes. J Develop Physiol 15, 247–252.

    CAS  Google Scholar 

  • Satoh H & Sperelakis N (1992a). Taurine inhibition of fast Na+ current in embryonic chick ventricular myocytes. Eur J Pharmacol (in press).

    Google Scholar 

  • Satoh H & Sperelakis N (1992b)Taurine effects on Ca2+ currents in young embryonic chick cardiomyocytes. J Mol Cell Cardiol submitted.

    Google Scholar 

  • Sawamura A, Azuma J, Harada H, Hasegawa H, Ogura K, Sperelakis N & Kishimoto S (1983). Protection by oral pretreatment with taurine against the negative inotropic effects of low calcium medium on isolated perfused chick heart. Cardiovas Res 17, 620–626.

    Article  CAS  Google Scholar 

  • Sawamura A, Sada H, Azuma J, Kishimoto S & Sperelakis N (1990). Taurine modulates ion influx through cardiac Ca2+ channels. Cell Calcium 11, 251–259.

    Article  PubMed  CAS  Google Scholar 

  • Sawamura A, Sperelakis N & Azuma J (1986a). Protective effect of taurine against decline of cardiac slow action potentials during hypoxia. Eur J Pharmacol 120, 235–23

    Article  PubMed  CAS  Google Scholar 

  • Sawamura A, Sperelakis N, Azuma J & Kishimoto S (1986b)Effects of taurine on the electrical and mechanical activities of embryonic chick heart. Can J Physiol Pharmacol 64, 649–655.

    Article  PubMed  CAS  Google Scholar 

  • Shigenobu K & Sperelakis N (1972). Calcium current channels induced by catecholamines in chick embryonic hearts whose fast sodium channels are blocked by tetrodotoxin or elevated potassium. Circ Res 31, 932–952.

    Article  PubMed  CAS  Google Scholar 

  • Sperelakis N (1984).Hormonal and neurotransmitter regulation of Ca2+ influx through voltage-dependent slow channels in cardiac muscle membrane. Proceedings of the Membrane Biophysics Symposium on “Molecular Mechanism of Hormonal Regulation of Ion Movement” (A. Shamoo, ed), San Diego, February 13, 1983. Membrane Biochem 5, 131–166.

    Google Scholar 

  • Sperelakis N, Satoh H & Bkaily G (1992). Taurine effects on ionic currents in myocardial cells. In: Lombardini B, Schaeffer S & Azuma J (Ed) Taurine: Nutritional Value and Mechanisms of Action,(in press).

    Google Scholar 

  • Sperelakis N & Schneider JA (1976). A metabolic control mechanism for calcium ion influx that may protect the ventricular myocardial cell.Am J Cardiol 37, 1079–1085.

    Article  PubMed  CAS  Google Scholar 

  • Sperelakis N, Yamamoto T, Bkaily G, Sada H, Sawamura A & Azuma J (1989). Taurine effects on action potentials and ionic currents in chick embryonic cells. In: Iwata H, Lombardini JB & Segawa T Taurine and the Heart. Kluwer Academic Pub, Boston, pp. 1–20.

    Chapter  Google Scholar 

  • Taber KH, Lin CT, Liu JW, Thalmann RT & Wu JY (1986).Taurine in hippocampus: Localization and postsynaptic action. Brain Res 386, 113–121.

    Article  PubMed  CAS  Google Scholar 

  • Takihara K, Azuma J, Awata N, Ohta H, Hamaguchi T, Sawamura A, Tanaka Y, Kishimoto S & Sperelakis N (1986). Beneficial effect of taurine in rabbits with chronic congestive heart failure. Am Heart J 111 (6), 1278–1284.

    Article  Google Scholar 

  • Takihara K, Azuma J, Awata N, Ohta H, Sawamura A, Kishimoto S & Sperelakis N (1985).Taurine's possible protective role in age-dependent response to calcium paradox. Life Sci 37, 1705–1710

    Article  PubMed  CAS  Google Scholar 

  • Tsien RY & Rink TJ (1980).Neutral carrier ion-selective microelectrodes for measurements of intracellular-free calcium. Biochim Biophys Acta 559, 623–638.

    Google Scholar 

  • Vogel S & Sperelakis N (1981).Induction of slow action potentials by microiontophoresis of cyclic AMP into heart cells. J Mol Cell Cardiol 13,51–64.

    Article  Google Scholar 

  • Wahler GM & Sperelakis N (1985).Intracellular injection of cyclic GMP depresses cardiac slow action potentials. J Cyclic Nucleotide & Protein Phosphorylation Res 10, 83–95.

    CAS  Google Scholar 

  • Yamauchi-Takihara K, Azuma J, Kishimoto S, Onishi S & Sperelakis N (1988).Taurine prevention of calcium paradox-related damage in cardiac muscle. Biochem Pharmacol 37, 2651–2658.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Physiology and Biophysics, University of Cincinnati, College of Medicine, Cincinnati, OH, 45267-0576, USA

    Nicholas Sperelakis & Hiroyasu Satoh

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  1. Nicholas Sperelakis
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  2. Hiroyasu Satoh
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Editors and Affiliations

  1. University Laboratory of Physiology, University of Oxford, Oxford, UK

    Denis Noble FRS. Hon MRCP

  2. Department of Physiology & Biophysics, Seoul National University College of Medicine, South Korea

    Yung E. Earm MD, PhD

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© 1993 Springer Science+Business Media New York

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Sperelakis, N., Satoh, H. (1993). Taurine Effects on Ion Channels of Cardiac Muscle. In: Noble, D., Earm, Y.E. (eds) Ionic Channels and Effect of Taurine on the Heart. Developments in Cardiovascular Medicine, vol 141. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3074-9_5

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  • DOI: https://doi.org/10.1007/978-1-4615-3074-9_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6342-2

  • Online ISBN: 978-1-4615-3074-9

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