Skip to main content
SpringerLink
Log in

‘In Vivo’ Model Systems to Study ras Oncogene Involvement in Carcinogenesis

  • Chapter
Oncogene and Transgenics Correlates of Cancer Risk Assessments

Part of the book series: NATO ASI Series ((NSSA,volume 232))

  • 71 Accesses

Abstract

Correlations have been reported between exposure to chemicals, radiation, viruses or certain diets and human cancer. Some chemicals have been pointed out as causative factors in specific tumor types (IARC, 1982; U.S. Department of Health and Human Services, 1983).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Barbacid, M. (1987). ras genes. Ann. Rev. Biochem. 56:779–827.

    Article  PubMed  CAS  Google Scholar 

  • Blair, D.G., C.S. Cooper, M.K. Oskarsson, L.A. Eader and G.F. Vande Woude (1982). New method for detecting cellular transforming genes. Science 218:1122–1125.

    Article  PubMed  CAS  Google Scholar 

  • Bos, J.L. (1989). ras oncogenes in human cancer: a review. Cancer Res. 49:4682–4689.

    PubMed  CAS  Google Scholar 

  • Bouchard, L., L. Lamarre, P.J. Tremblay, and P. Jolicoeur. (1989). Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene. Cell. 57:931–936.

    Article  PubMed  CAS  Google Scholar 

  • Choi, Y., D. Henrard, I. Lee, and S.R. Ross. (1987). The mouse mammary tumor virus long terminal repeat directs expression in epithelial and lymphoid cells of different tissues in transgenic mice. J. Virol. 61:3013–3019.

    PubMed  CAS  Google Scholar 

  • Choi, Y., I. Lee, and S.R. Ross. (1988). Requirement for simian virus 40 small tumor antigen in tumorigenesis in transgenic mice. Mol Cell Biol. 8(8):3382-3390.

    PubMed  CAS  Google Scholar 

  • DeFeo, D., M.A. Gonda, H.A. Young, E.H. Chang, D.R. Lowy, E.M. Scolnick, and R.W. Ellis. (1981). Analysis of two divergent rat genomic clones homologous to the transforming gene of Harvey murine sarcoma virus. Proc. Natl. Acad. Sci. USA. 78:3328–3332.

    Article  PubMed  CAS  Google Scholar 

  • Diamond, L., I. Guerrero, and A. Pellicer. (1988). Concomitant K- and N-ras gene point mutations in clonal murine lymphoma. Mol. Cell. Biol. 8(5):2233–2236.

    PubMed  CAS  Google Scholar 

  • Dong, Z., and A.M. Jeffrey. (1990). Mechanisms of organ specificity in chemical carcinogenesis. Cancer Investigation 8(5):523–533.

    Article  PubMed  CAS  Google Scholar 

  • Ellis, R.W., D. DeFeo, T.Y. Shih, M.A. Gonda, H.A. Young, N. Tsuchida, D.R. Lowy, and E. Scolnick. (1981). The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes. Nature. 292:506–511.

    Article  PubMed  CAS  Google Scholar 

  • Fasano, O., D. Birnbaum, K. Edlund, J. Fogh and M. Wigler (1984). New human trans-forming genes detected by a tumorigenicity assay. Mol. Cell. Biol. 4:1695–1705.

    PubMed  CAS  Google Scholar 

  • Gordon, J.W., and F.H. Ruddle. (1983). Gene transfer into mouse embryos: production of transgenic mice by pronuclear injection. Meth. Enzymol. 101:411–433.

    Article  PubMed  CAS  Google Scholar 

  • Gordon, J.W., G.A. Scangos, D.J. Plotkin, J.A. Barbosa, and F.H. Ruddle. (1980). Genetic transformation of mouse embryos by microinjection of purified DNA. Proc. Natl. Acad. Sci. USA 77:7380–7384.

    Article  PubMed  CAS  Google Scholar 

  • Guerrero, I., P. Calzada, A. Mayer, and A. Pellicer. (1984a). A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene. Proc. Natl. Acad. Sci. USA. 81:202–205.

    Article  CAS  Google Scholar 

  • Guerrero, I., A. Villasante, P. D’Eustachio, and A. Pellicer. (1984b). Isolation, characterization, and chromosome assignment of mouse N-ras gene from carcinogen-induced thymic lymphoma. Science 225 (4666):1041–1043.

    Article  CAS  Google Scholar 

  • Guerrero, I., and A. Pellicer (1987). Mutational activation of oncogenes in animal model systems of carcinogenesis. Mut. Res. 185:293–308.

    Article  CAS  Google Scholar 

  • Guerrero, I., A. Villasante, V. Corces, and A. Pellicer. (1985). Loss of the normal N-ras allele in a mouse thymic lymphoma induced by a chemical carcinogen. Proc. Natl. Acad. Sci. (U.S.A.), 82:7810–7814.

    Article  CAS  Google Scholar 

  • Gullino, P.M., Pettigrew, H.M., and F.M. Grantham. (1975). N-Nitroso-methylurea, a mammary gland carcinogen in rats. J. Natl. Cancer Inst. 54:401–414.

    PubMed  CAS  Google Scholar 

  • Hanahan, D. (1988). Dissecting multistep tumorigenesis in transgenic mice. Annu. Rev. Genet. 22:479–519.

    Article  PubMed  CAS  Google Scholar 

  • Hecker, E., N.E. Fusenig, W. Kunz, F. Marks, and H.W. Thielman. (1982). Cocarcino-genesis and biological effects of tumor promoters. Raven Press. New York

    Google Scholar 

  • IARC. (1982). IARC Monographs on the evaluation of the carcinogenic risk of chemicals to humans. Supplement 4.

    Google Scholar 

  • Kaplan, A.S. (1967). On the natural history of the murine leukemias. Cancer Res. 27:1325–1329.

    PubMed  CAS  Google Scholar 

  • Knudson, A.G. Jr. (1977). Genetic predisposition to cancer. In: Origins of Human Cancer. Hiatt, H.H., Watson, J.D. and Winsten, J.A. (eds.). Cold Spring Harbor Laboratory. New York. pp. 45–52.

    Google Scholar 

  • Leder, A., K. Pattengale, A. Kuo, T.A. Stewart, and P. Leder. (1986). Consequence of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasm and normal development. Cell 45:485–495.

    Article  PubMed  CAS  Google Scholar 

  • Leon, J., I. Guerrero, and A. Pellicer. (1987). Differential expression of the ras gene family in mice. Mol. Cell Biol. 7:1535–1540.

    PubMed  CAS  Google Scholar 

  • Mangues, R., I. Seidman, A. Pellicer, and J.W. Gordon. (1990a). Tumorigenesis and male sterility in transgenic mice expressing a MMTV/N-ras oncogene. Oncogene 5(9):1491–1497.

    CAS  Google Scholar 

  • Mangues, R., I. Seidman, A. Pellicer, and J.W. Gordon. (1990b). MMTV/N-ras transgenic mice as a model for altered capacitation, male sterility and tumorigenesis. In: Advances in assisted reproductive technologies. Mashiach et al. (eds.). Plenum Press, New York. pp. 939–957.

    Chapter  Google Scholar 

  • Muller, W.J., E. Sinn, P.K. Pattengale, R. Wallace, and P. Leder. (1988). Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell. 54:105–115.

    Article  PubMed  CAS  Google Scholar 

  • Newcomb, E.W., J.J. Steinberg, and A. Pellicer. (1988). ras oncogenes and phenotypic staging in N-Methylnitrosourea and gamma irradiation induced thymic lymphomas in C57BL/6J mice. Cancer Res. 48:5514–5521.

    PubMed  CAS  Google Scholar 

  • Pellicer, A. (1986). Gene purification by transfection methods. In: Gene transfer. Kucherlapati, R. (ed.). Plenum Publishing Co. pp. 263–287.

    Chapter  Google Scholar 

  • Pellicer, A., D. Robins, B. Wold, R. Sweet, J. Jackson, I. Lowy, J.M. Roberts, G.K. Sim, S. Silverstein, and R. Axel. (1980). Altering genotype and phenotype by DNA-mediated gene transfer. Science 209:1414–1422.

    Article  PubMed  CAS  Google Scholar 

  • Santos, E., D. Martin-Zanca, E.P. Reddy, M.A. Pierotti, G. Della Porta, and M. Barbacid. (1984). Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient. Science 223:661–664.

    Article  PubMed  CAS  Google Scholar 

  • Shih, C., B-Z. Shilo, M.P. Goldfarb, A. Dannenberg, and R.A. Weinberg. (1979). Passages of phenotypes of chemically transformed cells via transfection of DNA and chromatin. Proc. Natl. Acad. Sci. (U.S.A.), 76:5714–5718.

    Article  CAS  Google Scholar 

  • Shimizu, K., M. Goldfarb, M. Perucho, and M. Wigler. (1983). Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. Proc. Natl. Acad. Sci. USA. 80:383–387.

    Article  PubMed  CAS  Google Scholar 

  • Sinn, E., W. Muller, P. Pattengale, I. Tepler, R. Wallace, and P. Leder. 1987. Co-expression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo. Cell. 49:465–475.

    Article  PubMed  CAS  Google Scholar 

  • Sloan S.R., E.W. Newcomb, and A. Pellicer. (1990). Neutron radiation can activate K-ras via a point mutation in codon 146 and induces a different spectrum of ras mutations that does gamma radiation. Mol. Cell. Biol. 10(1):405–408.

    PubMed  CAS  Google Scholar 

  • Sorrentino, V., M.D. McKinney, M. Giorgi, R. Geremia, and E. Fleissner. (1988). Expression of cellular protooncogenes in the mouse male germ line: A distinctive 2.4 kilobasepim-1 transcript is expressed in haploid postmeiotic cells. Proc. Natl. Acad. Sci. USA. 85:2191–2195.

    Article  PubMed  CAS  Google Scholar 

  • Stewart, T.A., P.K. Pattengale, and P. Leder. (1984). Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes. Cell. 38:627–637.

    Article  PubMed  CAS  Google Scholar 

  • Sukumar, S. (1989). ras oncogenes in chemical carcinogenesis. Current Topics in Microbiology and Immunology 148:93–114.

    Article  PubMed  CAS  Google Scholar 

  • Tremblay, P.J., F. Pothier, T. Hoang, G. Tremblay, S. Brownstein, A. Liszauer, and P. Jolicoeur. (1989). Transgenic mice carrying the mouse mammary tumor virus ras fusion gene: distinct effects in various tissues. Mol. Cell Biol. 9:854–859.

    PubMed  CAS  Google Scholar 

  • U.S. Department of Health and Human Services. Public Health Service. (1983). Third Annual Report on Carcinogens. Summary. NTP 83–010. Springfield, Virginia.

    Google Scholar 

  • Weinberg, R.A. (1989). Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis. Cancer Res. 49:3713–3721.

    PubMed  CAS  Google Scholar 

  • Yuspa, S.H., and M.C. Poirier. (1988). Chemical carcinogenesis: from animal models to molecular models in one decade. Adv. Cancer Res. 50:25–70.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology and Kaplan Cancer Center, New York University Medical Center, New York, N.Y., 10016, USA

    Ramon Mangues & Angel Pellicer

Authors
  1. Ramon Mangues
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Angel Pellicer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Consulting in Health and Environmental Protection, Simpsonville, Maryland, USA

    Constantine Zervos

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer Science+Business Media New York

About this chapter

Cite this chapter

Mangues, R., Pellicer, A. (1992). ‘In Vivo’ Model Systems to Study ras Oncogene Involvement in Carcinogenesis. In: Zervos, C. (eds) Oncogene and Transgenics Correlates of Cancer Risk Assessments. NATO ASI Series, vol 232. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3056-5_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-3056-5_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6333-0

  • Online ISBN: 978-1-4615-3056-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation