Abstract
Mutations in Drosophila hold promise for studying effects of protein alterations on development, neurophysiology and behavior of the organism. For that purpose, several mutations which affect acetylcholinesterase (AChE) were isolated (Greenspan et al.,1980; Morton and Singh, 1984; Pralavorio and Fournier, 1992). These mutations are either lethal, temperature-sensitive or modify the catalytic properties of the enzyme. Lethal and conditional mutations were obtained by mutagenesis experiments and mutations affecting the catalytic properties of the enzyme were found in insects resistant to insecticides which have an altered AChE less sensitive to inhibition by organophosphate and carbamate compounds.
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Fournier, D., Mutero, A., Pralavorio, M., Bride, J.M. (1992). Drosophila Acetylcholinesterase: Analysis of Structure and Sensitivity to Insecticides by In Vitro Mutagenesis and Expression. In: Shafferman, A., Velan, B. (eds) Multidisciplinary Approaches to Cholinesterase Functions. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3046-6_10
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DOI: https://doi.org/10.1007/978-1-4615-3046-6_10
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