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In Vitro Targeting of Doxorubicin Loaded Canine Erythrocytes to Cytotoxic T-Lymphocytes (CTLL)

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The Use of Resealed Erythrocytes as Carriers and Bioreactors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 326))

Abstract

The treatment and therapy of many acute and chronic deseases has largely involved the administration of drugs via the standard delivery systems, e.g. oral, parenteral, intramuscular, and intravenous routes of administration. These methods of administering a drug usually result in an immediate bioavailability of the drug. Anti-tumor agents require a high concentration to achieve a therapeutically relevant dose to the tumor cells. However, the amount of the drug required usually proves to be toxic to normal tissues.

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© 1992 Springer Science+Business Media New York

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Gasparini, A., Chiarantini, L., Kirch, H., DeLoach, J.R. (1992). In Vitro Targeting of Doxorubicin Loaded Canine Erythrocytes to Cytotoxic T-Lymphocytes (CTLL). In: Magnani, M., DeLoach, J.R. (eds) The Use of Resealed Erythrocytes as Carriers and Bioreactors. Advances in Experimental Medicine and Biology, vol 326. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3030-5_35

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  • DOI: https://doi.org/10.1007/978-1-4615-3030-5_35

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6321-7

  • Online ISBN: 978-1-4615-3030-5

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