Abstract
The treatment and therapy of many acute and chronic deseases has largely involved the administration of drugs via the standard delivery systems, e.g. oral, parenteral, intramuscular, and intravenous routes of administration. These methods of administering a drug usually result in an immediate bioavailability of the drug. Anti-tumor agents require a high concentration to achieve a therapeutically relevant dose to the tumor cells. However, the amount of the drug required usually proves to be toxic to normal tissues.
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P.K. Gupta, Application of regression analysis in the evaluation of tumor response following the administration of adriamycin either as a solution or via albumin microspheres to the rat, J. Pharm. Sci. 79: 949 (1990).
J.R. DeLoach and U. Sprandel, Red Blood Cells as carriers for drugs, Karger, Basel (1985).
C. Ropars, M. Chassaigne and C. Nicolau, Red Blood Cells as carriers for drugs, Pergamon Press (1987).
J.R. DeLoach, C. Tangner and C. Barton, Hepatic Pharmacokinetics of Glutaraldehydetreated Methotrexate-loaded Carrier Erythrocytes in Dogs, Exp. Med. 183: 167 (1983).
E. Zocchi, M. Tonetti, C. Polvani, L. Guida, U. Benatti and A. De Flora, In vivo liver and lung targeting of doxorubicin encapsulated in glutaraldehyde-treated murine erythrocytes, Biotechnol. Appl. Biochem. 10: 555 (1988).
E. Zocchi, M. Tonetti, C. Polvani, L. Guida, U. Benatti and A. De Flora, Encapsulation of doxorubicin in liver-targeted erythrocytes increases the therapeutic index of the drug in a murine metastatic model, Proc. Natl. Acad. Sci. USA 86: 2040 (1989) 10.
M. Tonetti, A.B. Astroff, W. Satterfield, A. De Flora, U. Benatti and J.R. DeLoach, Pharmacokinetic properties of doxorubicin encapsulated in glutaraldehyde-treated canine erythrocytes, Am J Vet Res 52: 163 (1991).
S. Gillis and K.A. Smith, Long term culture of tumor-specific cytotoxic T cells (letter), Nature 268: 154 (1977).
A. De Flora, U. Benatti, L. Guida and E. Zocchi, E., Encapsulation of doxorubicin in human erythrocytes, Proc. Natl. Acad. Sci. USA 83: 7029 (1986).
A. Di Marco, M. Gaetani and B. Scarpinato, Doxorubicin (NSC- 23127); a new antibiotic with antitumor activity, Cancer Chemother. Rep. 53: 33 (1963).
E.A. Lefrak, J. Pitha, S. Rosenheim and J.A. Gottlieb, A clinicopathologic analysis of doxorubicin cardiotoxicity, Cancer 32: 302 (1973).
M. Tonetti, C. Polvani, E. Zocchi, L. Guida, U. Benatti, P. Biassoni, F. Romei, A. Guglielmi, C. Aschele, A. Sobrero and A. De Flora, Liver Targeting of autologous erythrocytes loaded with doxorubicin, Eur. J. Cancer 27: 947 (1991).
E.R. Gold and H.H. Fudenberg, Chromic Chloride: a coupling reagent for passive hemagglutination reactions, J. Immunol. 99: 859 (1967).
P.W. Faulk and V. Houba, Immunological reactions with chromic chloride-treated erythrocytes, J. Immunol. Methods 3: 87 (1973).
L. Chiarantini, R. Drolesky, M. Magnani and J.R. DeLoach, In Vitro targeting of erythrocytes to cytotoxic T-cells by coupling of Thy-1.2 monoclonal antibody, Biotechnol. Appl. Biochem. 15 (1992).
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Gasparini, A., Chiarantini, L., Kirch, H., DeLoach, J.R. (1992). In Vitro Targeting of Doxorubicin Loaded Canine Erythrocytes to Cytotoxic T-Lymphocytes (CTLL). In: Magnani, M., DeLoach, J.R. (eds) The Use of Resealed Erythrocytes as Carriers and Bioreactors. Advances in Experimental Medicine and Biology, vol 326. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3030-5_35
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DOI: https://doi.org/10.1007/978-1-4615-3030-5_35
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