Abstract
T cells dominate early cellular immune responses against many viruses and are potentially protective (Zinkernagel and Doherty, 1979; Blanden, 1974). There is some evidence that cytotoxic T cells destroy virus-infected cells before viral progeny are assembled (Zinkernagel and Doherty, 1979; Blanden, 1974), thus eliminating virus during the eclipse phase of virus replication. Virus elimination via immunological host cell destruction is, in the case of cytopathic viruses, an efficient way to prevent virus spread and the resulting more extensive virus-mediated cell and tissue damage. In the case of noncytopathic viruses, this immunological defense mechanism becomes less attractive because host cells are not destroyed by virus but only by the T-cell immune response. Because T cells apparently cannot distinguish cytopathic from noncytopathic viruses, immune-mediated cell and tissue damage often results, in the latter infections, in immunopathology (Zinkernagel and Doherty, 1979).
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Zinkernagel, R.M. (1993). Virus-Induced Acquired Immunosuppression by T-Cell-Mediated Immunopathology and Vaccine Strategies. In: Salvato, M.S. (eds) The Arenaviridae. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3028-2_14
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DOI: https://doi.org/10.1007/978-1-4615-3028-2_14
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