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Development of the Central Nervous System in Vertebrates pp 49–73Cite as

Hox Genes and the Development of the Branchial Region

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Part of the book series: NATO ASI Series ((NSSA,volume 234))

Abstract

One of the key events in early development is positional specification, the process by which initially equivalent parts of a developing structure become different from one another. Once such differences are established the localised production of the substances can occur which eventually causes morphological differences to become apparent in a structure that was originally homogenous. The combination of molecular biology with genetics in the last ten years has begun to indicate how some stages of this process may come about during the early development of the vertebrate central nervous system and the structures associated with it.

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References

  • AKAM, M. (1987). The molecular basis for metameric pattern in the Drosophila embryo. Development 101, 1–22.

    PubMed  CAS  Google Scholar 

  • ANDERSON, C. & MEIER, S. (1981). The influence of the metameric pattern in the mesoderm on migration of cranial neural crest cells in the chick embryo. Devl Biol. 85, 385–402.

    Article  CAS  Google Scholar 

  • BAROFFIO, A., DUPIN, E. & LE DOUARIN, N. (1991). Common precursors for neural and mesenchymal derivatives in the cephalic neural crest. Development 112, 301–305.

    PubMed  CAS  Google Scholar 

  • BEEMAN, R. (1987). A homeotic gene cluster in the red flour beetle. Nature 327, 247–249.

    Article  Google Scholar 

  • BEEMAN, R., STUART, J., HAAS, M. & DENELL, R. (1989). Genetic analysis of the homeotic gene complex (HOM-C) in the beetle Tribolium castaneum. Devl Biol. 133, 196–209.

    Article  CAS  Google Scholar 

  • BRONNER-FRASER, M. & FRASER, S. (1988). Cell lineage analysis reveals multipotency of some avian neural crest cells. Nature 335, 161–164.

    Article  PubMed  CAS  Google Scholar 

  • CHISAKA, O. & CAPECCHI, M. (1991). Regionally restricted developmental defects resulting from targetted disruption of the mouse homeobox gene hox1.5. Nature 350, 473–479.

    CAS  Google Scholar 

  • COHEN, S. & JURGENS, G. (1990). Mediation of Drosophila head development by gap-like segmentation genes. Nature 346, 482–485.

    Article  PubMed  CAS  Google Scholar 

  • D’AMICO-MARTEL, A. & NODEN, D. (1983). Contributions of placodal and neural crest cells to avian cranial peripheral ganglia. Am. J. Anat. 166, 445–468.

    Article  PubMed  Google Scholar 

  • DAVIS, C., HOLMYARD, D., MILLEN, K. & JOYNER, A. (1991). Examining pattern formation in mouse,chicken and frog embryos with an En-specific antiserum. Development 111, 287–298.

    PubMed  CAS  Google Scholar 

  • DENCKER, L., ANNERWALL, E., BUSCH, C. & ERIKSSON, U. (1990). Localization of specific retinoid-binding sites and expression of cellular retinoic-acid-binding protein (CRABP) in the early mouse embryo. Development 110, 343–352.

    PubMed  CAS  Google Scholar 

  • DOLLE, P., IZPISUA-BELMONTE, J. C., FALKENSTEIN, H., RENUCCI, A. & DUBOULE, D. (1989). Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation. Nature 342, 767–772.

    Article  PubMed  CAS  Google Scholar 

  • DOLLE, P., RUBERTE, E., LEROY, P., MORRISS-KAY, G. & CHAMBON, P. (1990). Retinoic acid receptors and cellular retinoid binding proteins. I. A systematic study of their differential pattern of transcription during mouse organogenesis. Development 110, 1133–1151.

    PubMed  CAS  Google Scholar 

  • DUBOULE, D. & DOLLE, P. (1989). The structural and functinal organization of the murine HOX gene family resembles that of Drosophila homeotic genes. EMBO 8, 1497–1505.

    CAS  Google Scholar 

  • DURSTON, A., TIMMERMANS, J., HAGE, W., HENDRIKS, H., DE VRIES, N., HEIDEVELD, M. & NIEUWKOOP, P. (1989). Retinoic acid causes an anteroposterior transformation in the developing central nervous system. Nature 340, 140–144.

    Article  PubMed  CAS  Google Scholar 

  • FINKELSTEIN, R. & PERRIMON, N. (1990). The orthodenticle gene is regulated by bicoid and torso and specifies Drosophila head development. Nature 346, 485–488.

    Article  PubMed  CAS  Google Scholar 

  • FRASER, S., KEYNES, R. & LUMSDEN, A. (1990). Segmentation in the chick embryo hindbrain is defined by cell lineage restrictions. Nature 344, 431–435.

    Article  PubMed  CAS  Google Scholar 

  • GAUNT, S. J., KRUMLAUF, R. & DUBOULE, D. (1989). Mouse homeo-genes within a subfamily, Hox-1.4, -2.6 and -5.1, display similar anteroposterior domains of expression in the embryo, but show stage-and tissue-dependent differences in their regulation. Development 107, 131–141.

    PubMed  CAS  Google Scholar 

  • GAUNT, S. J., COLETTA, P. L., PRAVTCHEVA, D. & SHARPE, P. T. (1990). Mouse Hox-3.4: homeobox sequence and embryonic expression patterns compared with other members of the Hox gene network. Development 109, 329–339.

    PubMed  CAS  Google Scholar 

  • GEHRING, W. (1987). Homeoboxes in the study of development. Science 236, 1245–1252.

    Article  PubMed  CAS  Google Scholar 

  • GRAHAM, A, PAPALOPULU, N., LORIMER, J., MCVEY, J., TUDDENHAM, E. & KRUMLAUF, R. (1988). Characterization of a murine homeo box gene, Hox 2.6 ,related to the drosophila deformed gene. Genes Dev. 2, 1424–1438.

    Article  PubMed  CAS  Google Scholar 

  • GRAHAM, A, PAPALOPULU, N. & KRUMLAUF, R. (1989). The murine and Drosophila homeobox clusters have common features of organisation and expression. Cell 57, 367–378.

    Article  PubMed  CAS  Google Scholar 

  • GRAHAM, A., MADEN, M. & KRUMLAUF, R. (1991). The murine Hox-2 genes display dynamic dorsoventral patterns of expression during central nervous system development. Development 112, 255–264.

    PubMed  CAS  Google Scholar 

  • GUTHRIE, S. & LUMSDEN, A. (1991). Formation and regeneration of rhombomere boundaries in the developing chick hindbrain. Development 112, 221–229.

    PubMed  CAS  Google Scholar 

  • HALL, B. (1987). Tissue Interactions in Head Development and Evolution. In Developmental and Evolutionary Aspects of the Neural Crest (ed. P. F. A. Maderson), pp. 215–259. New York: John Wiley.

    Google Scholar 

  • HEMMATI-BRIVANLOU, A., DE LA TORRE, J., HOLT, C. & HARLAND, R.(1991). Cephalic expression and molecular characterisation of Xenopus En-2. Development 111, 715–724.

    PubMed  CAS  Google Scholar 

  • HOLLAND, P. & HOGAN, B. (1988). Expression of homeo box genes during mouse development: a review. Genes Dev. 2, 773–782.

    Article  PubMed  CAS  Google Scholar 

  • HUNT, P., GULISANO, M., COOK, M., SHAM, M., FAIELLA, A., WILKINSON, D., BONCINELLI, E. & KRUMLAUF, R. (1991a). A distinct Hox code for the branchial region of the head. Nature 353, 861–864.

    Article  PubMed  CAS  Google Scholar 

  • HUNT, P., WHITING, J., MUCHAMORE, I., MARSHALL, H. & KRUMLAUF, R. (1991b). Homeobox genes and models for patterning the hindbrain and branchial arches. Development 112 (Supplement: Molecular and cellular basis of pattern formation), 187–196.

    Google Scholar 

  • HUNT, P., WHITING, J., NONCHEV, S., SHAM, M., MARSHALL, H., GRAHAM, A., ALLEMANN, R., RIGBY, P., GULISANO, M., FAIELLA, A., BONCINELLI, E. & KRUMLAUF, R. (1991c). The branchial Hox code and its implications for gene regulation, patterning of the nervous system and head evolution. Development 113 (Supplement, Developmental Nerve Cell Biology), In press.

    Google Scholar 

  • HUNT, P., WILKINSON, D. & KRUMLAUF, R. (1991d). Patterning the vertebrate head: murine Hox 2 genes mark distinct subpopulations of premigratory and migrating neural crest. Development 112, 43–51.

    PubMed  CAS  Google Scholar 

  • IZPISUA-BELMONTE, J.-C., DOLLE, P., RENUCCI, A., ZAPPAVIGNA, V., FALKENSTEIN, H. & DUBOULE, D. (1990). Primary structure and embryonic expression pattern of the mouse Hox-4.3 homeobox gene. Development 110, 733–745.

    PubMed  CAS  Google Scholar 

  • IZPISUA-BELMONTE, J.-C., TICKLE, C., DOLLE, P., WOLPERT, L. & DUBOULE,D. (1991). Expression of homeobox Hox-4 genes and the specification of position in chick wing development. Nature 350, 585–589.

    Article  PubMed  CAS  Google Scholar 

  • JONES, C. M., LYONS, K. & HOGAN, B. (1991). Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse. Development 111, 531–542.

    PubMed  CAS  Google Scholar 

  • KESSEL, M. & GRUSS, P. (1990). Murine developmental control genes. Science 249, 374–379.

    Article  PubMed  CAS  Google Scholar 

  • KESSEL, M. & GRUSS, P. (1991). Homeotic transformations of murine prevertebrae and concommitant alteration of Hox codes induced by retinoic acid. Cell In press.

    Google Scholar 

  • KESSEL, M., BALLING, R. & GRUSS, P. (1990). Variations of cervical vertebrae after expression of a Hox 1.1 transgene in mice. Cell 61, 301–308.

    Article  PubMed  CAS  Google Scholar 

  • KIRBY, M. (1989). Plasticity and predetermination of the mesencephalic and trunk neural crest transplanted into the region of cardiac neural crest. Devl Biol. 134, 402–412.

    Article  CAS  Google Scholar 

  • KURATANI, S. & KIRBY, M. (1991). Initial Migration and distribution of the cardiac neural crest in the avian embryo: An introduction to the concept of the circumpharyngeal crest. Am. J. Anat. 191, 215–227.

    Article  PubMed  CAS  Google Scholar 

  • LE DOUARIN, N. (1983). The Neural Crest. Cambridge: Cambridge University Press.

    Google Scholar 

  • LE DOUARIN, N., FONTAINE-PERUS, J. & COULY, G. (1986). Cephalic ectodermal placodes and neurogenesis. TINS 9, 175–180.

    Google Scholar 

  • LEWIS, E. (1978). A gene complex controlling segmentation in Drosophila. Nature 276, 565–570.

    Article  PubMed  CAS  Google Scholar 

  • LUFKIN, T., DIERICH, A., LEMEUR, M., MARK, M. & CHAMBON, P. (1991). Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression. Cell 66, 1105–1119.

    Article  PubMed  CAS  Google Scholar 

  • LUMSDEN, A. (1990a). The cellular basis of segmentation in the developing hindbrain. TINS 13, 329–335.

    PubMed  CAS  Google Scholar 

  • LUMSDEN, A. (1990b). The Development and Significance of Hindbrain Segmentation. In Seminars in Developmental Biology: The Evolution of Segmental Patterns ,vol. 1, issue 2 (ed. C. Stern), pp. 117–125. Philadelphia: W.B. Saunders.

    Google Scholar 

  • LUMSDEN, A. & KEYNES, R. (1989). Segmental patterns of neuronal development in the chick hindbrain. Nature 337, 424–428.

    Article  PubMed  CAS  Google Scholar 

  • LUMSDEN, A., SPRAWSON, N. & GRAHAM, A. (1991). Segmental origin and migration of neural crest cells in the hindbrain region of the chick embryo. Development 113, In press.

    Google Scholar 

  • MADEN, M., HUNT, P. N., ERIKSSON, U., KUROIWA, A., KRUMLAUF, R. & SUMMERBELL, D. (1991). Retinoic acid-binding protein and homeobox expression in the rhombomeres of the chick embryo. Development 111, 35–44.

    PubMed  CAS  Google Scholar 

  • MCKEE, G. & FERGUSON, M. (1984). The effects of mesencephalic neural crest cell extirpation on the development of chicken embryos. J. Anat. 139, 491–512.

    PubMed  Google Scholar 

  • MCMAHON, A. & BRADLEY, A. (1990). The Wnt-1 (int-1) proto-oncogene is required for development of a large region of mouse brain. Cell 62, 1073–1085.

    Article  PubMed  CAS  Google Scholar 

  • MOODY, S. & HEATON, M. (1983a). Developmental relationships between trigeminal ganglia and trigeminal motorneurons in chick embryos. I. ganglion development is necessary for motorneuron migration. J. Comp. Neurol. 213, 327–343.

    Article  PubMed  CAS  Google Scholar 

  • MOODY, S. & HEATON, M. (1983b). Developmental relationships between trigeminal ganglia and trigeminal motorneurons in chick embryos. II. ganglion axon ingrowth guides motorneuron migration. J. Comp. Neurol. 213, 344–349.

    Article  PubMed  CAS  Google Scholar 

  • MORRISS, G. M. & THOROGOOD, P. V. (1978). An Approach to Cranial Neural Crest Migration and Differentiation in Mammalian Embryos. In Development in Mammals ,vol. 3 (ed. M. H. Johnson), pp. 363–411. Amsterdam: Elsevier North-Holland.

    Google Scholar 

  • MURPHY, P. & HILL, R. (1991). Expression of mouse labial-like homeobox-containing genes, Hox 2.9 and Hox 1.6 ,during segmentation of the hindbrain. Development 111, 61–74.

    PubMed  CAS  Google Scholar 

  • MURPHY, P., DAVIDSON, D. & HILL, R. (1989). Segment-specific expression of a homeobox-containing gene in the mouse hindbrain. Nature 341, 156–159.

    Article  PubMed  CAS  Google Scholar 

  • NICHOLS, D. (1981). Neural crest formation in the head of the mouse embryo as observed using a new histological technique. JEEM 64, 105–120.

    CAS  Google Scholar 

  • NODEN, D. (1983). The role of the neural crest in patterning of avian cranial skeletal, connective, and muscle tissues. Devl Biol. 96, 144–165.

    Article  CAS  Google Scholar 

  • NODEN, D. (1988). Interactions and fates of avian craniofacial mesenchyme. Development 103(Supplement; Craniofacial Development), 121–140.

    PubMed  Google Scholar 

  • NOHNO, T., NOJI, S., KOYAMA, E., OHYAMA, K., MYOKAI, F., KUROIWA, A., SAITO, T. & TANAGUCHI, S. (1991). Involvement of the Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development. Cell 64, 1197–1205.

    Article  PubMed  CAS  Google Scholar 

  • . A mouse gene related to Distal-less shows a restricted expression in the developing forebrain. Nature 351, 748–751.

    Article  PubMed  CAS  Google Scholar 

  • ROMER, A. (1971). The Vertebrate Body, Shorter Version ,Fourth edn. Philadelphia: W. B. Saunders Company. (pp 163–167)

    Google Scholar 

  • ROWE, A., RICHMAN, J. & BRICKELL, P. (1991). Retinoic acid treatment alters the distribution of retinoic acid receptor beta transcripts in the embryonic chick face. Development 111, 1007–1016.

    PubMed  CAS  Google Scholar 

  • RUIZ-I-ALTABA, A. (1990). Neural expression of the Xenopus homeobox gene Xhox3: evidence for a patterning neural signal that spreads through the ectoderm. Development. 108, 595–604.

    PubMed  CAS  Google Scholar 

  • SIMEONE, A., PANNESE, M., ACAMPORA, D., D’ESPOSITO, M. & BONCINELLI, E. (1988). At least three human homeoboxes on chromosome 12 belong to the same transcription unit. N.A.R. 16, 5379–5390.

    Article  CAS  Google Scholar 

  • SIMEONE, A., ACAMPORA, D., NIGRO, V., FAIELLA, A., D’ESPOSITO, M., STORNAIUOLO, A., MAVILIO, F. & BONCINELLI, E. (1991). Differential regulation by retinoic acid of the homeobox genes of the four HOX loci in human embryonal carcinoma cells. Mechanisms of Development 33, 215–227.

    Article  PubMed  CAS  Google Scholar 

  • SULIK, K., COOK, C. & WEBSTER, W. (1988). Teratogens and craniofacial malformations: relationships to cell death. Development 103, 213–232.

    PubMed  CAS  Google Scholar 

  • TAN, S. S. & MORRISS-KAY, G. (1985). The development and distribution of the cranial neural crest in the rat embryo. Cell Tissue Res. 240, 403–416.

    Article  PubMed  CAS  Google Scholar 

  • THOROGOOD, P. (1988). The developmental specification of the vertebrate skull. Development 103, 141–153.

    PubMed  Google Scholar 

  • THOROGOOD, P., BEE, J. & VON DER MARK, K. (1986). Transient expression of collagen type II at epitheliomesenchymal interfaces during morphogenesis of the cartilaginous neurocranium. Devl Biol. 116, 497–509.

    Article  CAS  Google Scholar 

  • VAESSEN, M.-J., MEIJERS, J., BOOTSMA, D. & VAN KESSEL, A. (1990). The cellular retinoic-acid-binding protein is expressed in tissues associated with retinoic-acid-induced malformations. Development 110, 371–378.

    PubMed  CAS  Google Scholar 

  • VERWOERD, C. & VAN OOSTROM, C. (1979). Advances in Anatomy, Embryology and Cell Biology ,58: Cephalic Neural Crest and Placodes. Berlin: Springer-Verlag.

    Google Scholar 

  • WILKINSON, D., BAILES, J. & MCMAHON, A. (1987). Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo. Cell 50, 79–88.

    Article  PubMed  CAS  Google Scholar 

  • WILKINSON, D., BHATT, S., CHAVRIER, P., BRAVO, R. & CHARNAY, P.(1989a). Segment-specific expression of a zinc finger gene in the developing nervous system of the mouse. Nature 337, 461–464.

    Article  PubMed  CAS  Google Scholar 

  • WILKINSON, D., BHATT, S., COOK, M., BONCINELLI, E. & KRUMLAUF, R. (1989b). Segmental expression of hox 2 homeobox-containing genes in the developing mouse hindbrain. Nature 341, 405–409.

    Article  PubMed  CAS  Google Scholar 

  • WOOD, A, ASHHURST, D., CORBETT, A. & THOROGOOD, P. (1991). The transient expression of type II collagen at tissue interfaces during mammalian craniofacial development. Development 111, 955–968.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. MRC Laboratory of Eukaryotic Molecular Genetics, NIMR, The Ridgeway, Mill Hill, London, NW7 1AA, UK

    Paul Hunt & Robb Krumlauf

  2. IIGB, Via Marconi 12, 80125, Naples, Italy

    Edoardo Boncinelli

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  1. Paul Hunt
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  2. Edoardo Boncinelli
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  3. Robb Krumlauf
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Editors and Affiliations

  1. New York Medical College, Valhalla, New York, USA

    S. C. Sharma

  2. Université Notre Dame de la Paix, Namur, Belgium

    A. M. Goffinet

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Hunt, P., Boncinelli, E., Krumlauf, R. (1992). Hox Genes and the Development of the Branchial Region. In: Sharma, S.C., Goffinet, A.M. (eds) Development of the Central Nervous System in Vertebrates. NATO ASI Series, vol 234. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3018-3_5

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  • DOI: https://doi.org/10.1007/978-1-4615-3018-3_5

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