Abstract
In previous studies we have demonstrated molecular mimicry between the S peplomer protein of Mouse Hepatitis Virus (MHV) and Fcγ Receptor (FcγR) of IgG. Rabbit IgG, but not its F(ab’)2 fragments, monoclonal rat and mouse IgG and the rat 2.4G2 anti-mouse FcγR monoclonal antibody (mab) immunoprecipitated natural and recombinant MHV S protein. On the basis of a number of criteria, MHV S peplomer protein exhibits Fc IgG binding ability. We report here a molecular mimicry between the S peplomer protein of Bovine Coronavirus (BCV) and FcγR. BCV S peplomer protein which belongs to the same antigenic subgroup as MHV also binds Fc portion of rabbit IgG and is immunoprecipitated by the 2.4G2 anti-FcγR mab. In contrast, Transmissible Gastroenteritis Coronavirus (TGEV) and Infectious Bronchitis Virus (IBV) S peplomer proteins which represent two distinct antigenic subgroups of Coronaviridae do not bind rabbit IgG and do not react with anti-FcγR mab. However, homologous swine IgG, but not its F(ab’)2 fragments, immunoprecipitated from TGEV-infected cells a polypeptide chain with molecular mass of 195 kDa, identical to that immunoprecipitated by the T36 mab anti-TGEV S peplomer protein.
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Keywords
- Infectious Bronchitis Virus
- Molecular Mimicry
- Mouse Hepatitis Virus
- Feline Infectious Peritonitis Virus
- Control Uninfected Cell
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© 1994 Springer Science+Business Media New York
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Oleszak, E.L., Perlman, S., Parr, R., Collisson, E.W., Leibowitz, J.L. (1994). Molecular Mimicry between S Peplomer Proteins of Coronaviruses (MHV, BCV, TGEV and IBV) and Fc Receptor. In: Laude, H., Vautherot, JF. (eds) Coronaviruses. Advances in Experimental Medicine and Biology, vol 342. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2996-5_29
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DOI: https://doi.org/10.1007/978-1-4615-2996-5_29
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