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RAP1B and Platelet Function

  • Chapter
Mechanisms of Platelet Activation and Control

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 344))

Abstract

Platelets contain multiple low molecular weight GTP-binding proteins which share strong sequence similarity to ras including rap, rac, ral, and rho (Nagata et al., 1989; Polakis et al., 1989). In addition, platelets contain regulatory molecules which both control the hydrolysis of GTP bound to the protein and/or promote the exchange of GDP for GTP (Hart et al., 1991). Surprisingly, platelets do not contain the ras molecule in a significant amount, yet possess high levels of the ras regulatory molecule rasGAP. RasGAP has been shown to bind rapla with high affinity without increasing its GTPase activity (Frech et al., 1990). It is generally accepted that in addition to rasGAP acting as a GTPase activating protein, it may function as the downstream target molecule of ras (Hall, 1990a). For this reason, the role of rasGAP and rapl in platelets is intriguing given that platelets also contain the GTPase activating protein specific for rapl. Recent data has proposed that this complex interaction may play a controling role in platelet signal transduction.

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Authors and Affiliations

  1. Division of Cell Biology, Burroughs Wellcome Co., 3030 Cornwallis Road Research Triangle Park, North Carolina, 27709, USA

    Eduardo G. Lapetina & Francis X. Farrell

Authors
  1. Eduardo G. Lapetina
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  2. Francis X. Farrell
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Editors and Affiliations

  1. Thrombosis Research Institute, London, UK

    Kalwant S. Authi  & Vijay V. Kakkar  & 

  2. University of Oxford, Oxford, UK

    Steve P. Watson

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© 1993 Springer Science+Business Media New York

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Lapetina, E.G., Farrell, F.X. (1993). RAP1B and Platelet Function. In: Authi, K.S., Watson, S.P., Kakkar, V.V. (eds) Mechanisms of Platelet Activation and Control. Advances in Experimental Medicine and Biology, vol 344. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2994-1_4

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  • DOI: https://doi.org/10.1007/978-1-4615-2994-1_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6304-0

  • Online ISBN: 978-1-4615-2994-1

  • eBook Packages: Springer Book Archive

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