Abstract
The platelet cytoplasm is filled with a network of actin filaments. The organization of these filaments is regulated by their association with proteins such as α-actinin, tropomyosin, and actin-binding protein (Fox, 1987). When platelets are activated, myosin associates with these cytoplasmic actin filaments, thus generating the tension required for the centralization of granules (Fox and Phillips, 1982; Painter and Ginsberg, 1984). New filaments are formed by the polymerization of monomeric actin (Carlsson et a1, 1979; Jennings et al, 1981); polymerization of these new filaments induces the extension of filopodia (Casella et al, 1981).
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© 1993 Springer Science+Business Media New York
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Fox, J.E.B. (1993). Regulation of Platelet Function by the Cytoskeleton. In: Authi, K.S., Watson, S.P., Kakkar, V.V. (eds) Mechanisms of Platelet Activation and Control. Advances in Experimental Medicine and Biology, vol 344. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2994-1_13
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DOI: https://doi.org/10.1007/978-1-4615-2994-1_13
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