Synthesis and Characterization of IGF-II Analogs: Applications in the Evaluation of IGF Receptor Function and IGF-Independent Actions of IGFBPS

  • Youngman Oh
  • Hermann L. Müller
  • Heping Zhang
  • Nicholas Ling
  • Ron G. Rosenfeld
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 343)


The elucidation of the mechanisms involved in the biological actions of the IGFs has been hampered by the complexity of the IGF system: three peptide ligands (IGF-I, IGF-II and insulin),1 three receptors (type 1 and type 2 IGF receptors and insulin receptors)2 and six distinct, but structurally related binding proteins (IGFBP-1 to IGFBP-6).3 The physiological interactions among these components of the IGF system are not completely understood, although they have all been cloned and sequenced.4


Insulin Receptor Hs578T Cell Specific Biological Action Human Rhabdomyosarcoma Cell Western Ligand Blot 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Youngman Oh
    • 1
  • Hermann L. Müller
    • 1
  • Heping Zhang
    • 2
  • Nicholas Ling
    • 2
  • Ron G. Rosenfeld
    • 1
  1. 1.Dept. of Pediatrics, Div. of EndocrinologyStanford University School of MedicineStanfordUSA
  2. 2.Dept. of Molecular EndocrinologyThe Whittier Institute for Diabetes and EndocrinologyLa JollaUSA

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