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Characterization of the IGF Regulatory System in Bone

  • Subburaman Mohan
  • David J. Baylink
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 343)

Abstract

There are two major dynamic processes in bone: bone formation and bone resorption which determine the volume of bone and ultimately its strength. Because bone is a tissue which is continuously remodeling, bone formation is an essential part of skeletal maintenance even after the growth period where bone formation is obviously essential. Moreover, bone has a remarkable regenerative potential which enables it to remodel itself in response to changing physical demands, and to repair itself after injury. In the majority of the adult skeleton, bone formation is confined to specific remodeling sites. Whether bone is lost or gained will depend on the extent of bone formation in each one of these sites. With regard to the mediators of bone formation, growth factors have received much attention. Of the several growth factors present in bone (IGF-I, IGF-II, TGF-β1, TGF-β2, PDGF, basic FGF, acidic FGF and BMPs), there is now sufficient evidence to document an important role for the IGFs in the local regulation of bone formation. In this paper we describe the components of the IGF regulatory system and discuss evidence supporting a role for IGFs in the local regulation of bone formation.

Keywords

Bone Formation Bone Cell Human Bone Cell Bone Cell Proliferation Colon Cancer Cell Growth Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Subburaman Mohan
    • 1
  • David J. Baylink
    • 1
  1. 1.Departments of Medicine, Biochemistry and PhysiologyLoma Linda University and Pettis VA Medical CenterLoma LindaUSA

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