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Characterization of the IGF Regulatory System in Bone

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Current Directions in Insulin-Like Growth Factor Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 343))

Abstract

There are two major dynamic processes in bone: bone formation and bone resorption which determine the volume of bone and ultimately its strength. Because bone is a tissue which is continuously remodeling, bone formation is an essential part of skeletal maintenance even after the growth period where bone formation is obviously essential. Moreover, bone has a remarkable regenerative potential which enables it to remodel itself in response to changing physical demands, and to repair itself after injury. In the majority of the adult skeleton, bone formation is confined to specific remodeling sites. Whether bone is lost or gained will depend on the extent of bone formation in each one of these sites. With regard to the mediators of bone formation, growth factors have received much attention. Of the several growth factors present in bone (IGF-I, IGF-II, TGF-β1, TGF-β2, PDGF, basic FGF, acidic FGF and BMPs), there is now sufficient evidence to document an important role for the IGFs in the local regulation of bone formation. In this paper we describe the components of the IGF regulatory system and discuss evidence supporting a role for IGFs in the local regulation of bone formation.

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Author information

Authors and Affiliations

  1. Departments of Medicine, Biochemistry and Physiology, Loma Linda University and Pettis VA Medical Center, Loma Linda, CA, 92357, USA

    Subburaman Mohan & David J. Baylink

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  1. Subburaman Mohan
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  2. David J. Baylink
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Editor information

Editors and Affiliations

  1. National Institutes of Health, Bethesda, Maryland, USA

    Derek Le Roith M.D., Ph.D.

  2. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada Ph.D.

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© 1994 Springer Science+Business Media New York

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Mohan, S., Baylink, D.J. (1994). Characterization of the IGF Regulatory System in Bone. In: Le Roith, D., Raizada, M.K. (eds) Current Directions in Insulin-Like Growth Factor Research. Advances in Experimental Medicine and Biology, vol 343. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2988-0_37

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  • DOI: https://doi.org/10.1007/978-1-4615-2988-0_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6301-9

  • Online ISBN: 978-1-4615-2988-0

  • eBook Packages: Springer Book Archive

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