Insulin-Like Growth Factor (IGF) Binding Protein-1 is an Antigonadotropin: Evidence that Optimal Follicle-Stimulating Hormone Action in Ovarian Granulosa Cells is Contingent upon Amplification by Endogenously-Derived IGFs

  • Eli Y. Adashi
  • C. E. Resnick
  • R. G. Rosenfeld
  • D. R. Powell
  • R. Koistinen
  • E. M. Rutanen
  • M. Seppala
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 343)


Implicit in the antigonadotropic property of IGFBPs is the presumption that they sequester endogenously-generated IGFs thereby diminishing their access to cognate cell surface receptors and hence their cellular hormonal action. This communication examines this concept and the relevance of endogenous IGF to FSH action.

Key Words

IGF Ovary Binding Proteins Gonadotropins 


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Eli Y. Adashi
    • 1
  • C. E. Resnick
    • 1
  • R. G. Rosenfeld
    • 2
  • D. R. Powell
    • 3
  • R. Koistinen
    • 4
  • E. M. Rutanen
    • 4
    • 5
  • M. Seppala
    • 4
  1. 1.Division of Reproductive Endocrinology, Departments of Obstetrics, Gynecology, and PhysiologyUniversity of Maryland School of MedicineBaltimoreUSA
  2. 2.Department of PediatricsStanford University Medical CenterStanfordUSA
  3. 3.Department of PediatricsBaylor College of MedicineHoustonUSA
  4. 4.Department of Obstetrics/GynecologyHelsinki University Central HospitalHelsinkiFinland
  5. 5.Minerva Institute for Medical ResearchHelsinkiFinland

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