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IGF-II in the Pathogenesis of Rhabdomyosarcoma: A Prototype of IGFs Involvement in Human Tumorigenesis

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Current Directions in Insulin-Like Growth Factor Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 343))

Abstract

In recent years there has been a growing interest in the role of peptide growth factors in the regulation of the biologic behavior of several human malignancies. Among those peptides that might have importance in neoplastic pathogenesis are the insulin-like growth factors I and II (IGF-I and IGF-II). These proteins have been shown to stimulate myoblast proliferation and differentiation (1), to promote nutrient uptake and to inhibit proteolysis (2, 3). IGF-II mRNA is highly expressed in human skeletal fetal muscle tissue, but it is not detectable in normal adult skeletal muscle by standard Northern analysis and in situ hybridization (4). In mouse myoblasts, IGF-I and IGF-II mRNA levels increase transiently (IGF-II > > IGF-I) within 48-72 hours of the beginning of the myogenic differentiation process. The expression of mRNA is accompanied by secretion of the peptides in the culture medium that peaks at hour 92. IGF-I receptors increase transiently, doubling by 48 hours after the onset of differentiation, while IGF-II receptors increase and remain at a higher number throughout the differentiated state (5, 6). The production of IGF-binding proteins of Mr 29,000 to 32,000 is also induced throughout differentiation (7).

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Author information

Authors and Affiliations

  1. Pediatric Department, Georgetown University Medical Center, Washington, DC, 20007, USA

    Caterina P. Minniti & Lee J. Helman

  2. Pediatric Branch, National Cancer Institute, Bethesda, MD, 20892, USA

    Caterina P. Minniti & Lee J. Helman

Authors
  1. Caterina P. Minniti
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  2. Lee J. Helman
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Editors and Affiliations

  1. National Institutes of Health, Bethesda, Maryland, USA

    Derek Le Roith M.D., Ph.D.

  2. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada Ph.D.

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© 1994 Springer Science+Business Media New York

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Minniti, C.P., Helman, L.J. (1994). IGF-II in the Pathogenesis of Rhabdomyosarcoma: A Prototype of IGFs Involvement in Human Tumorigenesis. In: Le Roith, D., Raizada, M.K. (eds) Current Directions in Insulin-Like Growth Factor Research. Advances in Experimental Medicine and Biology, vol 343. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2988-0_32

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  • DOI: https://doi.org/10.1007/978-1-4615-2988-0_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6301-9

  • Online ISBN: 978-1-4615-2988-0

  • eBook Packages: Springer Book Archive

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