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Cellular Actions of Insulin-Like Growth Factor Binding Protein-3

  • Chapter
Current Directions in Insulin-Like Growth Factor Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 343))

Abstract

Insulin-like growth factor I (IGF-I) plays a major role in regulating growth of cells in vivo and in vitro (1). IGF-I initiates metabolic and mitogenic processes in a wide variety of cell types by binding to specific type I IGF receptors in the plasma membrane (2). In addition, recent evidence suggests that association of IGF-I with distinct binding proteins present in extracellular fluids plays a pivotal role in determining IGF-I availability and bioactivity (3,4).

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Author information

Authors and Affiliations

  1. Endocrine Research Unit, Mayo Clinic and Mayo Foundation, 5-164 West Joseph, Rochester, MN, 55905, USA

    Cheryl A. Conover, Jay T. Clarkson, Susan K. Durham & Laurie K. Bale

Authors
  1. Cheryl A. Conover
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  2. Jay T. Clarkson
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  3. Susan K. Durham
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  4. Laurie K. Bale
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Editor information

Editors and Affiliations

  1. National Institutes of Health, Bethesda, Maryland, USA

    Derek Le Roith M.D., Ph.D.

  2. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada Ph.D.

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© 1994 Springer Science+Business Media New York

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Conover, C.A., Clarkson, J.T., Durham, S.K., Bale, L.K. (1994). Cellular Actions of Insulin-Like Growth Factor Binding Protein-3. In: Le Roith, D., Raizada, M.K. (eds) Current Directions in Insulin-Like Growth Factor Research. Advances in Experimental Medicine and Biology, vol 343. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2988-0_25

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  • DOI: https://doi.org/10.1007/978-1-4615-2988-0_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6301-9

  • Online ISBN: 978-1-4615-2988-0

  • eBook Packages: Springer Book Archive

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