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Rapid Regulation of Insulin-Like Growth Factor Binding Protein-1 Transcription by Insulin in Vivo and in Vitro

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Current Directions in Insulin-Like Growth Factor Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 343))

Abstract

Insulin-like growth factor binding protein-1 (IGFBP-1) is distinctive among the IGFBPs in human plasma in its dynamic regulation by metabolic changes [reviewed in 1]. IGFBP-1 levels are increased by acute fasting 2,3 and in diabetes 4,5, and normalized by refeeding and insulin treatment, respectively. IGFBP-1 also is increased by prolonged exercise, growth hormone deficiency and pregnancy 1, and following insulin-induced hypoglycemia 6.

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Author information

Authors and Affiliations

  1. Growth and Development Section, Molecular and Cellular Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA

    Matthew M. Rechler, Guck T. Ooi, Dae-shik Suh & Lucy Tseng

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  1. Matthew M. Rechler
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  2. Guck T. Ooi
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  3. Dae-shik Suh
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  4. Lucy Tseng
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Editor information

Editors and Affiliations

  1. National Institutes of Health, Bethesda, Maryland, USA

    Derek Le Roith M.D., Ph.D.

  2. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada Ph.D.

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© 1994 Springer Science+Business Media New York

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Rechler, M.M., Ooi, G.T., Suh, Ds., Tseng, L. (1994). Rapid Regulation of Insulin-Like Growth Factor Binding Protein-1 Transcription by Insulin in Vivo and in Vitro. In: Le Roith, D., Raizada, M.K. (eds) Current Directions in Insulin-Like Growth Factor Research. Advances in Experimental Medicine and Biology, vol 343. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2988-0_22

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  • DOI: https://doi.org/10.1007/978-1-4615-2988-0_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6301-9

  • Online ISBN: 978-1-4615-2988-0

  • eBook Packages: Springer Book Archive

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