Abstract
Insulin-like growth factor binding protein-1 (IGFBP-1) is a 25 kiloDalton protein which can compete with IGF receptors for binding of IGF-I and IGF-II peptides. Such high affinity binding allows IGFBP-1 to influence IGF action; IGFBP-1 can inhibit or potentiate the effects of IGF peptides depending on experimental conditions and on post-translational modifications of this binding protein (1). IGFBP-1 is expressed in a tissue-specific manner, with significant expression essentially limited to liver and uterus in most individuals (2,3).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Lee, P.D.K., Conover, C.A., and Powell, D.R., Regulation and function of insulin-like growth factor binding protein-1, Proc. Soc. Exp. Biol. Med. ,in press.
Brinkman, A., Groffen, C., Kortleve, D.J., Geurts van Kessel, A., and Drop, S.L.S., Isolation and characterization of a cDNA encoding the low MWIGFBP (IBP-1). EMBO J 7:2417–2423 (1988).
Mohn, K., Melby, A., Tewari, D., Laz, T., and Taub, R. The gene encoding IGFBP1 is rapidly and highly induced in regenerating liver. Mol. Cell. Biol. 11:1393–1401 (1991).
Drop, S.L.S., Kortleve, D.J., and Guyda, H.J., Immunoassay of a somatomedin BP from human amniotic fluid: levels in fetal, neonatal and adult sera. J. Clin. Endocrinol. Metab. 59:908–915 (1984).
Conover, C.A., Butler, P.C., Wang, M., Rizza, R.A., and Lee, P.D.K., Lack of growth hormone effect on insulin-associated suppression of IGFBP-1 in humans. Diabetes 39:1251–1256 (1990).
Lewitt, M.S., Denyer, G.S., Cooney, G.J., and Baxter, R.C., Insulin-like growth factor binding protein-1 modulates blood glucose levels. Endocrinol. 129:2254–2256 (1991).
Sasaki, K., Cripe, T.P., Koch, S.R., Andreone, T.L., Peterson, D.D., and Granner, D.K., Multihormonal regulation of PEPCK gene transcription. J. Biol. Chem. 259:15242–15251 (1984).
Magnuson, M.A., Quinn, P.G., and Granner, D.K., Multihormonal regulation of phosphoenolpyruvate carboxykinase-CAT fusion gene. J. Biol. Chem. 262:14917–14920 (1987).
Liu, J., Park, E.A., Gurney, A.L., Roesler, W.J., and Hanson, R.W., cAMP induction of PEPCK gene transcription is mediated by multiple promoter elements. J. Biol. Chem. 266:19095–19102 (1991).
O’Brien, R.M., Lucas, P.C., Forest, C.D., Magnuson, M.A., and Granner, D.K., Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription. Science 249:533–537 (1990).
Conover, C.A., Divertie, G.D., and Lee, P.D.K., Cortisol increases plasma insulin-like growth factor binding protein-1 in humans. Acta Endocrinol. ,in press.
Luo, J., Reid, R.E., and Murphy, L.J., Dexamethasone increases hepatic IGFBP-1 mRNA and serum IGFBP-1 concentrations in the rat. Endocrinol. 127:1456–1462 (1990).
Ooi, G.T., Tseng, L.Y.-H., Tran, M.Q., and Rechler, M.M., Insulin rapidly decreases IGFBP-1 gene transcription in streptozotocin-diabetic rats. Mol. Endocrinol 6:2219–2228 (1992).
Lewitt, M.S., and Baxter, R.C., Regulation of growth hormone-independent IGFBP (BP-28) in cultured human fetal liver explants. J. Clin. Endocrinol. Metab. 69:246–252 (1989).
Orlowski, C.C., Ooi, G.T., and Rechler, M.M., Dexamethasone stimulates transcription of the IGFBP-1 gene in H4-II-E rat hepatoma cells. Mol. Endocrinol. 4:1592–1599 (1990).
Powell, D.R., Suwanichkul, A., Cubbage, M.L., DePaolis, L.A., Snuggs, M.B., and Lee, P.D.K., Insulin inhibits transcription of the human gene for IGFBP-1. J. Biol. Chem. 266:18868–18876 (1991).
Unterman, T.G., (Dehler, D.T., Murphy, L.J., and Lacson, R.G., Multihormonal regulation of IGFBP-1 in rat H4IIE hepatoma cells: The dominant role of insulin. Endocrinol. 128:2693–2701 (1991).
Powell, D.R., Lee, P.D.K., DePaolis, L.A., Morris, S.L., and Suwanichkul, A., Dexamethasone stimulates expression of IGFBP-1 in HEP G2 human hepatoma cells. Growth Reg. 3:11–13 (1993).
Suwanichkul, A., DePaolis, L.A., Lee, P.D.K., and Powell, D.R., Identification of a promoter element which participates in cAMP-stimulated expression of human IGFBP-1. J. Biol. Chem. ,in press.
Imai, E., Miner, J.N., Mitchell, J.A., Yamamoto, K.R., and Granner, D.K., Glucoœrticoid receptorcAMP response element binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids. J. Biol. Chem. 268:5353–5356 (1993).
Park, E.A., Roesler, W.J., Liu, J., Klemm, D.L., Gurney, A.L., Thatcher, J.D., Shuman, J., Friedman, A., and Hanson, R.W., The role of the CCAAT/Enhancer binding-protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase (GTP). Mol. Cell. Biol. 10:6264–6272 (1990).
Suwanichkul, A., Cubbage, M.L., and Powell, D.R., The promoter of the human gene for insulin-like growth factor binding protein-1. J. Biol. Chem. 265:21185–21193 (1990).
déWet, J.,Wood, K., De Luca, M., Helinski, D., and Subramani, S., Firefly luciferase gene: Structure and expression in mammalian cells. Mol. Cell. Biol. 7:725–737 (1987).
Borman, C., Moffat, L., and Howard, B., Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044–1051 (1982).
Needleman, S.B., and Wunsch, C.D., A general method applicable to the search for similarities in the amino acid sequence of two proteins. J. Mol. Biol. 48:443–453 (1970).
Unterman, T.G., Lacson, R.G., McGary, E., Whalen, C., Purple, C., and Goswami, R.G., Cloning of the rat IGFBP-1 gene and analysis of its’ 5’ promoter region. Biochem. Biophys. Res. Comm. 185:993–999 (1992).
Mendel, D.B., and Crabtree, G.R., HNF-1, a member of a novel class of dimerizing homeodomain proteins. J. Biol. Chem. 266:677–680 (1991).
Powell, D.R., and Suwanichkul, A., HNF1 activates transcription of the human gene for IGFBP-1. DNA Cell Biol. 12:283–289 (1993).
Blumenfeld, M., Maury, M., Chouard, T., Yaniv, M., and Condamine, H., HNF1 shows a wider distribution than products of its known target genes in developing mouse. Development 113:589–599 (1991).
De Simone, V., DeMagistris, L., Lazzaro, D., Gerstner, J., Monaci, P., Nicosia, N., and Cortese, R., LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia. EMBOJ 10:1435–1444 (1991).
Chin, E., Zhou, J., and Bondy, C., Anatomical relationships in the patterns of IGF-I, IGFBP-1, and IGF-I receptor gene expression in the rat kidney. Endocrinol 130:3237–3245 (1992).
Suikkari, A.-M., Koivisto, V.A., Koistinen, R., Seppala, M., and Yki-Jarvinen, H., Dose-response characteristics for suppression of low MW IGFBP by insulin. J. Clin. Endocrinol. Metab. 68:135–140 (1989).
Conover, C.A., and Lee, P.D.K., Insulin regulation of IGFBP production in cultured HEP G2 cells. J. Clin. Endocrinol. Metab. 70:1062–1067 (1990).
Lee, P.D.K., Suwanichkul, A., DePaolis, L.A., Snuggs, M.B., Morris, S.L., and Powell, D.R., IGF suppression of IGFBP-1 production: Evidence for mediation by the type I IGF receptor.. Reg. Peptides, in press.
Suwanichkul, A., Morris, S.L., and Powell, D.R., Identification of an insulin responsive element in the promoter of the human gene for IGFBP-1. J. Biol. Chem. ,in press.
Johnson, T.M., Rosenberg, M.P., and Meisler, M.H., An insulin-responsive element in the pancreatic enhancer of the amylase gene. J. Biol. Chem. 268:464–468,1993.
Hilding, A., Thoren, M., and Hall, K., The effect of glucagon on serum IGFBP-1 levels in GH deficient patients. In: Binoux, M., Zapf, J., eds. 2nd International Workshop on IGFBPs ,Opio, France, 111 (abstract 98B) (1992).
Montminy, M.R., Gonzalez, G.A., and Yamamoto, K., Characteristics of the cAMP response unit. Rec. Prog. Hormone Res. 46:219–230 (1990).
Habener, J.F., Cyclic AMP response element binding proteins: A cornucopia of transcription factors. Mol. Endocrinol. 4:1087–1094 (1990).
Imai, E., Stromstedt, P.-E., Quinn, P.G., Carlstedt-Duke, J., Gustafsson, J.-A., and Granner, D.K., Characterization of a complex glucocorticoid response unit in the PEPCK gene. Mol. Cell. Biol. 10:4712–4719 (1990).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
Powell, D.R., Lee, P.D.K., Suwanichkul, A. (1994). Multihormonal Regulation of IGFBP-1 Promoter Activity. In: Le Roith, D., Raizada, M.K. (eds) Current Directions in Insulin-Like Growth Factor Research. Advances in Experimental Medicine and Biology, vol 343. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2988-0_20
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2988-0_20
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6301-9
Online ISBN: 978-1-4615-2988-0
eBook Packages: Springer Book Archive