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Multihormonal Regulation of IGFBP-1 Promoter Activity

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Current Directions in Insulin-Like Growth Factor Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 343))

Abstract

Insulin-like growth factor binding protein-1 (IGFBP-1) is a 25 kiloDalton protein which can compete with IGF receptors for binding of IGF-I and IGF-II peptides. Such high affinity binding allows IGFBP-1 to influence IGF action; IGFBP-1 can inhibit or potentiate the effects of IGF peptides depending on experimental conditions and on post-translational modifications of this binding protein (1). IGFBP-1 is expressed in a tissue-specific manner, with significant expression essentially limited to liver and uterus in most individuals (2,3).

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Authors and Affiliations

  1. Department of Pediatrics, Baylor College of Medicine, Houston, Texas, 77030, USA

    David R. Powell, Phillip D. K. Lee & Adisak Suwanichkul

Authors
  1. David R. Powell
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  2. Phillip D. K. Lee
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  3. Adisak Suwanichkul
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Editors and Affiliations

  1. National Institutes of Health, Bethesda, Maryland, USA

    Derek Le Roith M.D., Ph.D.

  2. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada Ph.D.

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© 1994 Springer Science+Business Media New York

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Powell, D.R., Lee, P.D.K., Suwanichkul, A. (1994). Multihormonal Regulation of IGFBP-1 Promoter Activity. In: Le Roith, D., Raizada, M.K. (eds) Current Directions in Insulin-Like Growth Factor Research. Advances in Experimental Medicine and Biology, vol 343. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2988-0_20

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  • DOI: https://doi.org/10.1007/978-1-4615-2988-0_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6301-9

  • Online ISBN: 978-1-4615-2988-0

  • eBook Packages: Springer Book Archive

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