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Multihormonal Regulation of IGFBP-1 Promoter Activity

  • David R. Powell
  • Phillip D. K. Lee
  • Adisak Suwanichkul
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 343)

Abstract

Insulin-like growth factor binding protein-1 (IGFBP-1) is a 25 kiloDalton protein which can compete with IGF receptors for binding of IGF-I and IGF-II peptides. Such high affinity binding allows IGFBP-1 to influence IGF action; IGFBP-1 can inhibit or potentiate the effects of IGF peptides depending on experimental conditions and on post-translational modifications of this binding protein (1). IGFBP-1 is expressed in a tissue-specific manner, with significant expression essentially limited to liver and uterus in most individuals (2,3).

Keywords

Promoter Activity Phosphoenolpyruvate Carboxykinase cAMP Effect PEPCK Gene CGTCA Motif 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • David R. Powell
    • 1
  • Phillip D. K. Lee
    • 1
  • Adisak Suwanichkul
    • 1
  1. 1.Department of PediatricsBaylor College of MedicineHoustonUSA

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