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The Insulin-Like Growth Factor-II/Mannose-6-Phosphate Receptor: Structure, Function and Differential Expression

  • Wieland Kiess
  • Andreas Hoeflich
  • Yi Yang
  • Ulrike Kessler
  • Allan Flyvbjerg
  • Bruno Barenton
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 343)

Abstract

The insulin like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor is a bifunc-tional binding protein that binds lysosomal enzymes bearing the M6P recognition marker and IGF-II at distinct binding sites (45, 52). In addition, transforming growth factor (TGF) beta precursor, thyroglobulin and proliferin, a protein which is expressed in rapidly proliferating cells are also recognized by this receptor (Table 1). In avian and amphibian cells the receptor lacks the binding site for IGF-II but serves as a binding protein for M6P bearing ligands (7,9,76). Almost all mammalian cells described until today express IGF-II/M6P receptors that bind both classes of ligands, namely M6P-containing glycoproteins and IGF-II (55–59).

Keywords

Lysosomal Enzyme MCF7 Mammary Carcinoma Cell MCF7 Mammary Carcinoma Trisphosphate Formation Extracytoplasmic Region 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Wieland Kiess
    • 1
  • Andreas Hoeflich
    • 1
  • Yi Yang
    • 2
  • Ulrike Kessler
    • 1
  • Allan Flyvbjerg
    • 3
  • Bruno Barenton
    • 4
  1. 1.Cell Biology Laboratory, Dept. Pediatric Endocrinology, Children’s HospitalUniversity of MunichMunich 2Germany
  2. 2.Children’s HospitalMedical UniversityShanghaiPeople’s Republic of China
  3. 3.Institute of Experimental Clinical ResearchKommunehospitalet University of AarhusAarhusDenmark
  4. 4.Laboratoire de Croissance et Differenciation CellulaireINRAF-Montpellier CedexFrance

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