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Immunological Studies of Type I IGF Receptors and Insulin Receptors: Characterisation of Hybrid and Atypical Receptor Subtypes

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Current Directions in Insulin-Like Growth Factor Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 343))

Abstract

The insulin receptor (IR) and type I IGF receptor (IGFR) are widely distributed in mammalian tissues, though varying in concentration between different cell types. The receptors show considerable similarity in primary sequence within a common disulphide linked (αβ)2 subunit structure. The insulin receptor-related receptor (IRR), a third member of this receptor family for which a ligand has yet to be identified, apparently has a much more restricted tissue distribution (Shier and Watt, 1992). The IR and IGFR mediate overlapping biological responses for which the intrinsic tyrosine-specific kinase activity of the receptors appears to be essential. These tyrosine kinases are highly homologous and differences in signalling capacities of the IR and IGFR in a given cell background have not been clearly defined.

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Authors and Affiliations

  1. Department of Clinical Biochemistry, University of Cambridge, Addenbrooke’s Hospital, Cambridge, CB2 2QR, UK

    Maria A. Soos, Barbara T. Navé & Kenneth Siddle

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  1. Maria A. Soos
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  2. Barbara T. Navé
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  3. Kenneth Siddle
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Editors and Affiliations

  1. National Institutes of Health, Bethesda, Maryland, USA

    Derek Le Roith M.D., Ph.D.

  2. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada Ph.D.

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Soos, M.A., Navé, B.T., Siddle, K. (1994). Immunological Studies of Type I IGF Receptors and Insulin Receptors: Characterisation of Hybrid and Atypical Receptor Subtypes. In: Le Roith, D., Raizada, M.K. (eds) Current Directions in Insulin-Like Growth Factor Research. Advances in Experimental Medicine and Biology, vol 343. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2988-0_15

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  • DOI: https://doi.org/10.1007/978-1-4615-2988-0_15

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