Abstract
The interaction of the IGF-1 receptor with its ligands (IGF-1, IGF-II and insulin at supraphysiological concentrations) plays a major role in normal development and in the control of both normal and abnormal growth (for reviews, see Werner et al., 1991 and Lowe, 1991). The importance of the IGF-1 receptor in development is especially supported by the seminal experiments of Efstratiadis and co-workers (DeChiara et al., 1990, and personal communication). These investigators have shown that targeted disruption of the IGF-II gene results in progeny, which, at birth, has a body weight that is 70% the body weight of wild type litter mates. When both the IGF-II and the IGF-1 receptor genes are disrupted by homologous recombination, the homozygous mutant embryos at birth have a body weight that is only 30% the weight of wild type litter mates. Thus, it can be stated that the activation of IGF-1 receptor by its ligands (IGF-1 or IGF-II) accounts for 70% of embryonal murine growth.
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Abbreviations
- IGF-1 or IGF-II:
-
insulin-like growth factor 1 or II
- SV40:
-
simian virus 40
- PDGF:
-
platelet derived growth factor
- EGF:
-
epidermal growth factor
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© 1994 Springer Science+Business Media New York
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Baserga, R., Porcu, P., Rubini, M., Sell, C. (1994). Cell Cycle Control by the IGF-1 Receptor and Its Ligands. In: Le Roith, D., Raizada, M.K. (eds) Current Directions in Insulin-Like Growth Factor Research. Advances in Experimental Medicine and Biology, vol 343. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2988-0_11
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DOI: https://doi.org/10.1007/978-1-4615-2988-0_11
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