Abstract
The insulin-like growth factor-I receptor (IGF-I-R) is a trans-membrane tyrosine kinase which mediates the trophic, metabolic, and differentiative effects of IGF-I and IGF-II1,2. Beginning at early organogenesis, the IGF-I-R gene is constitutively expressed by most body tissues, consistent with the putative role of IGF-I as a progression factor in the cell cycle3. Recent studies have shown that overexpression of the IGF-I-R in a fibroblast cell line abrogates all requirements for exogenous growth factors, suggesting that this receptor does, in fact, mediate a central mechanism in the cell cycle4.
Keywords
- Chinese Hamster Ovary Cell
- Normal Kidney Tissue
- Heterologous Element
- Normal Adjacent Kidney
- Liver Nuclear Extract
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
D. LeRoith, M. Adamo, H. Werner, and C.T. Roberts, Jr, Insulin-like growth factors, their binding proteins and receptors as growth regulators in normal physiology and pathological states, Trends in Endocrinol. Metab. 2:134–139 (1991).
H. Werner, M. Woloschak, B. Stannard, Z. Shen-Orr, C.T. Roberts, Jr., and D. LeRoith, The insulin-like growth factor I receptor: molecular biology, heterogeneity and regulation, in: “Insulin-Like Growth Factors: Molecular and Cellular Aspects,” D. LeRoith, ed., CRC Press, Boca Raton (1991).
E. Di Cicco-Bloom and I.B. Black, Insulin growth factors regulate the mitotic cycle in cultured rat sympathetic neuroblasts, Proc. Natl. Acad. Sci. USA. 85:4066–(1988).
Z. Pietrzkowski, R. Lammers, G. Carpenter, A.M. Soderquist, M. Limardo, P.D.Phillips, A. Ullrich, and R. Baserga, Constitutive expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor abrogates all requirements for exogenous growth factors, Cell Growth and Differentiation ,3:199–205 (1992).
H. Werner, M. Woloschak, M. Adamo, Z. Shen-Orr, C.T. Roberts, Jr., and D. LeRoith,Developmental regulation of the rat insulin-like growth factor I receptor gene, Proc. Natl. Acad. Sci. USA. 86:7451–7455 (1989).
W.L. Lowe, Jr., M. Adamo, C.T. Roberts, Jr., and D. LeRoith, Regulation by fasting of rat insulin-like growth factor I and its receptor: effects on gene expression and binding, J. Clin. Invest. 84:619–626 (1989).
A. Ota, Z. Shen-Orr, C.T. Roberts, Jr., and D. LeRoith, TPA-induced neurite formation in a neuroblastoma cell line (SH-SY5Y) is associated with increased IGF-I receptor mRNA and binding, Mol Brain Res. 6:69–76 (1989).
H. Werner, Z. Shen-Orr, B. Stannard, B. Burguera, C.T. Roberts, Jr., and D. LeRoith, Experimental diabetes increases insulin-like growth factor I and II receptor concentration and gene expression in kidney, Diabetes 39:1490–1497 (1990).
K.J. Cullen, D. Yee, W.L. Sly, J. Perdue, B. Hampton, M.E. Lippman, N. Rosen, Insulin-like growth factor receptor expression and function in human breast cancer, Cancer Res. 50:48–53 (1990).
R.P. Glick, R. Gettleman, K. Patel, R. Lakshman, J.C.M Tsibris, Insulin and insulinlike growth factor I in brain tumors: binding and in vitro effects, Neurosurgery 24:791–797 (1989).
H. Werner, B. Stannard, M.A. Bach, D. LeRoith, and C.T. Roberts, Jr., Cloning and characterization of the proximal promoter region of the rat insulin-like growth factor I (IGF-I) receptor gene, Biochem. Biophys. Res. Commun. 169:1021–1027 (1990).
H. Werner, M.A. Bach, B. Stannard, C.T. Roberts, Jr., and D. LeRoith, Structural and functional analysis of the insulin-like growth factor I receptor gene promoter, Mol Endocrinol. 6:1545–1558 (1992).
D.W. Cooke, L.A. Bankert, C.T. Roberts, Jr., D. LeRoith, and S.J. Casella, Analysis of he human type I insulin-like growth factor receptor promoter region, Biochem. Biophys. Res. Commun. 177:1113–1120 (1991).
P.W. Mamula and I.D. Goldfine, Cloning and characterization of the human insulin-like growth factor-I receptor gene 5’-flanking region, DNA and Cell Biology 11:43–50 (1992).
S.T. Smale and D. Baltimore, The “initiator” as a transcription control element, Cell 57:103–113 (1989).
M.R. Briggs, J.T. Kadonaga, S.P. Bell, and R. Tjian, Purification and biochemical characterization of the promoter-specific transcription factor Sp1, Science ,234:47–52 (1986).
A.J. Courey and R. Tjian, Analysis of Spl in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif, Cell 55:887–898 (1988).
J.D. Saffer, S.P. Jackson, and M.B. Annarella, Developmental expression of Spl in the mouse, Mol. Cell Biol. 11:2189–2199 (1991).
R. Ammendola, M. Mesuraca, T. Russo, and F. Cimino, Spl DNA binding efficiency is highly reduced in nuclear extracts from aged rat tissues, J. Biol. Chem. 267:17944–17948 (1992).
C.A. Bondy, H. Werner, C.T. Roberts, Jr., and D. LeRoith, Cellular pattern of insulinlike growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expression, Mol. Endocrinol. 4:1386–1398 (1990).
C.A. Bondy, H. Werner, C.T. Roberts, Jr., and D. LeRoith, Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors-I and -II, Neuroscience 46:909–923 (1991).
E. Chin, J. Zhou, and C.A. Bondy, Anatomical relationships in the patterns of insulinlike growth factor (IGF)-I, IGF binding protein -1, and IGF-I receptor gene expression in the rat kidney, Endocrinology 130:3237–3245 (1992).
M. Kaleko, W.J. Rutter, and A.D. Miller, Overexpression of the human insulin-like growth factor I receptor promotes ligand-dependent neoplastic transformation, Mol. Cell Biol. 10:464–473 (1990).
A.J. Altman and A.D. Schwartz. “Malignant Diseases of Infancy, Childhood and Adolescence,” W.B. Saunders, Philadelphia (1978).
K.M. Call, T. Glaser, C.Y. Ito, A.J. Buckler, J. Pelletier, D.A. Haber, E.A. Rose, A. Kral, H. Yeger, W.H. Lewis, C. Jones, and D.E. Housman, Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms’ tumor locus, Cell 60:509–520 (1990).
E.A. Rose, T. Glaser, C. Jones, C.L. Smith, W.H. Lewis, K.M. Call, M. Minden, E. Champagne, W. Lewis, L. Bonetta, H. Yeger, and D.E. Housman, Complete physical map of the WAGR region of llpl3 localizes a candidate Wilms’ tumor gene, Cell 60:495–508 (1990).
F.G. Conti, L.J. Striker, M.A. Lesniak, K. Mackay, J. Roth, and G.E. Striker, Studies on binding and mitogenic effects of insulin and insulin-like growth factor I in glomerular mesangial cells, Endocrinology 122:2788–2795 (1988).
T. Gansler, K.D. Allen, C.F. Burant, T. Inabnett, A. Scott, M.G. Buse, D.A. Sens, and A.J. Garvin, Detection of type I insulinlike growth factor (IGF) receptors in Wilms’ tumors, Am. J. Pathol. 130:431–435 (1988).
T. Gansler, R. Furlanetto, T. Stokes-Gramling, K.A. Robinson, N. Blocker, M.G. Buse, D.A. Sens, and A.J. Garvin, Antibody to type I insulinlike growth factor receptor inhibits growth of Wilms, tumor in culture and in athymic mice, Am. J. Pathol. 135:961–966 (1989).
H. Werner, G.G. Re, I.A. Drummond, V.P. Sukhatme, F.J. Rauscher, III, D.A. Sens, A.J. Garvin, D. LeRoith, and C.T. Roberts, Jr., Increased expression of the insulin-like growth factor I receptor (IGF-I-R) gene in Wilms‘ tumor is correlated with modulation of IGF-I-R promoter activity by the WT1 Wilms’ tumor gene product, Submitted (1993).
A.E. Reeve, M.R. Eccles, R.J. Wilins, G.I. Bell, and L.J. Millow, Expression of insulinlike growth factor II transcripts in Wilms’ tumor, Nature 317:258–260 (1985).
G.K. Haselbacher, J.C. Irminger, J. Zapf, W.H. Ziegler, and R.E. Humbel, Insulin-like growth factor II in human adrenal pheochromocytomas and Wilms’ tumors: expression at the mRNA and protein level, Proc. Natl. Acad. Sci. USA 84:1104–1106 (1987).
F.J. Rauscher, III, J.F. Morris, O.E. Tournay, D.M. Cook, and T. Curran, Binding of the Wilms’ tumor locus zinc finger protein to the EGR-1 consensus sequence, Science 250:1259–1261 (1990).
S.L. Madden, D.M. Cook, J.F. Morris, A. Gashler, V.P. Sukhatme, and F.J. Rauscher, III, Transcriptional repression mediated by the WT1 Wilms tumor gene product, Science 253:1550–1553 (1991).
I.A. Drummond, S.L. Madden, P. Rohwer-Nutter, G.I. Bell, V.P. Sukhatme, and F.J. Rauscher, III, Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1, Science 257:674–678 (1992).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
Werner, H., Roberts, C.T., LeRoith, D. (1994). The Regulation of IGF-I Receptor Gene Expression by Positive and Negative Zinc-Finger Transcription Factors. In: Le Roith, D., Raizada, M.K. (eds) Current Directions in Insulin-Like Growth Factor Research. Advances in Experimental Medicine and Biology, vol 343. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2988-0_10
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2988-0_10
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6301-9
Online ISBN: 978-1-4615-2988-0
eBook Packages: Springer Book Archive