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Multiple Pathogens May Induce Growth Factor Cascade Resulting in KS

  • Chapter
Drugs of Abuse, Immunity, and AIDS

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 335))

Abstract

In this brief review a list of potential pathogens is provided that are associated with Kaposi’s sarcoma (KS) and may contribute to the initiation and/or maintenance of growth of KS cells. For the end result, which is the characteristic appearance and grouping of KS cells, the same growth factors are needed in a set sequence and combination. However, the pathogens inducing these growth factors may be different. Induction of the same growth factors by diverse pathogens can result in the generation of endothelial cell growth and transformation in sequence recognized as various subtypes of KS. Indeed there has to be an initiator of growth factor release from CD4 lymphocytes other than HIV in classical (Mediterranean) KS. On the other hand, HIV infection alone is not enough to induce KS: patients with hemophilia acquiring HIV infection through blood products die with AIDS but without developing KS.

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Author information

Authors and Affiliations

  1. Cancer Inst, St. Joseph’s Hospital, USA

    J. G. Sinkovics, J. E. Szakacs & F. Gyorkey

  2. Depts. of Med. & Med. Microbiol, Univ. of S. Florida College of Med, Tampa, FL, USA

    J. G. Sinkovics, J. E. Szakacs & F. Gyorkey

  3. H. Lee Moffitt Cancer Ctr. and Dept. of Pathol, University of S. Florida College of Med, Tampa, FL, USA

    J. G. Sinkovics, J. E. Szakacs & F. Gyorkey

  4. Veterans Adm. Med. Ctr. and Depts. of Pathol. and Virol, Baylor College of Med, Houston, TX, USA

    J. G. Sinkovics, J. E. Szakacs & F. Gyorkey

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  1. J. G. Sinkovics
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  2. J. E. Szakacs
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  3. F. Gyorkey
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Editors and Affiliations

  1. University of South Florida, Tampa, Florida, USA

    Herman Friedman , Thomas W. Klein  & Steven Specter ,  & 

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Sinkovics, J.G., Szakacs, J.E., Gyorkey, F. (1993). Multiple Pathogens May Induce Growth Factor Cascade Resulting in KS. In: Friedman, H., Klein, T.W., Specter, S. (eds) Drugs of Abuse, Immunity, and AIDS. Advances in Experimental Medicine and Biology, vol 335. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2980-4_35

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  • DOI: https://doi.org/10.1007/978-1-4615-2980-4_35

  • Publisher Name: Springer, Boston, MA

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