Skip to main content
SpringerLink
Log in

Small Animal Model of AIDS and the Feline Immunodeficiency Virus

  • Chapter
Drugs of Abuse, Immunity, and AIDS

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 335))

Abstract

Many aspects of the virology, epidemiology and prevention of AIDS are fairly well known, but the mechanisms whereby HIV produces the characteristic severe immune deficiency remain essentially obscure. Even more importantly, the armamentarium for controlling HIV infection is still extremely limited. For these reasons it is generally believed that AIDS research might profit greatly from the study of animal models.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. M. Bendinelli, D. Matteucci and H. Friedman, Retrovirus induced acquired immunodeficiencies, Adv. Cancer Res. 45:125 (1985).

    Article  PubMed  CAS  Google Scholar 

  2. M. B. Gardner and P.A. Luciw, Animal models of AIDS, FASEB J. 3:2593 (1989).

    PubMed  CAS  Google Scholar 

  3. H. Schellekens and M.C. Horzinek, “Animal models in AIDS,” Elsevier, Amsterdam (1990).

    Google Scholar 

  4. N. C. Pedersen, E.W. Ho, M.L. Brown and J.H. Yamamoto, Isolation of a T lymphotropic virus from domestic cats with an immunodeficiency-like syndrome, Science 235:790 (1987).

    Article  PubMed  CAS  Google Scholar 

  5. P. Bandecchi, D. Matteucci, F. Baldinotti, G. Guidi, F. Abramo, F. Tozzini F. and M. Bendinelli, Prevalence of feline immunodeficiency virus and other retroviral infections in Italy, Vet. Immunol. Immunopathol. 31:337 (1992).

    Article  PubMed  CAS  Google Scholar 

  6. N. C. Pedersen, Feline immunodeficiency virus infection, in: “The Retroviruses” vol. 2, in press, JA. Levy, ed., Plenum Press, New York (1992).

    Google Scholar 

  7. A. Poli, C. Giannelli, M. Pistello, L. Zaccaro, D. Pieracci, M. Bendinelli and G. Malvaldi, Detection of salivary antibodies in cats infected with feline immunodeficiency virus, J. Clin. Microb. 30:2038 (1992).

    CAS  Google Scholar 

  8. F. Mancianti, C. Giannelli, M. Bendinelli M. and A. Poli, Mycological findings in feline immunodeficiency virus-infected cats, Med. Vet. Mycol ,30:257 (1992).

    Article  CAS  Google Scholar 

  9. A. Poli, F. Abramo, E. Taccini, G. Guidi, P. Barsotti, M. Bendinelli and G. Malvaldi, Renal involvement in feline immunodeficiency virus infection: a clinico-pathological study, Nephron ,in press.

    Google Scholar 

  10. W. C. Brown, L. Bissey, K.S. Logan, N.C. Pedersen, J.H. Elder and E.W. Collíson, Feline immunodeficiency virus infects both CD4+ and CD8+ T lymphocytes, J. Virol. 65:3359 (1991).

    PubMed  CAS  Google Scholar 

  11. F. Tozzini, D. Matteucci, P. Bandecchi, F. Baldinotti, A. Poli, M. Pistello, K. H. J. Siebelink, L. Ceccherini-Nelli and M. Bendinelli, Simple in vitro methods for titrating feline immunodeficiency virus (F1V) and F1V neutralizing antibodies, J. Virol. Meth. 37:241 (1992).

    Article  CAS  Google Scholar 

  12. B. J. Willett, M.J. Hosie, T.H. Dunsford, J.C. Neil and O. Jarrett, Productive infection of T helper lymphocytes with feline immunodeficiency virus is accompanied by reduced expression of CD4,AIDS 5:1469 (1991).

    Article  PubMed  CAS  Google Scholar 

  13. L. Ceccherini-Nelli, R. Ghilarducci, M. Pistello, M. Rossi, M. Giorgi and M. Bendinelli, Molecular cloning and partial characterization of an Italian isolate of F1V from CNS tissue DNA, Proc. Workshop Eur. Commission Concerted Action on Feline AIDS, Lucca 18–21 June 1992, p. 11.

    Google Scholar 

  14. D. Matteucci, F. Baldinotti, P. Mazzetti, M. Pistello, P. Bandecchi, R. Ghilarducci, A. Poli, F. Tozzini and M. Bendinelli, Detection of feline immunodeficiency virus in saliva and plasma by cultivation and polymerase chain reaction, submitted.

    Google Scholar 

  15. N. C. Pedersen, M. Torten, B. Rideout, E. Sparger, T. Tonachini, P.A. Luciw, C.D. Ackley, N. Levy and J.H. Yamamoto, Feline leukemia virus infection as a potentiating cofactor for the primary and secondary stages of experimentally induced feline immunodeficiency virus infection, J. Virol. 64:598 (1990).

    PubMed  CAS  Google Scholar 

  16. C. Bartolomew, W.A. Blattner and F. Cleghorn, Progression to AIDS in homosexual men co-infected with HIV and HTLV-1 in Trinidad, Lancet 2:1469 (1987).

    Article  Google Scholar 

  17. D. Lin, D.D. Bowman and R.H. Jacobson, Immunological changes in cats with concurrent Toxoplasma gondii and feline immunodeficiency virus infections, J. Clin. Microb. 30:17 (1992).

    CAS  Google Scholar 

  18. S. Lombardi, M. Bendinelli and C. Garzelli, Detection of B epitopes on the p24 gag protein of feline immunodeficiency virus by monoclonal antibodies, Submitted.

    Google Scholar 

  19. T. W. North, R.C. Cronn, K.M. Remington and R.T. Tandberg, Direct comparison of inhibitor sensitivities of reverse transcriptases from feline and human immunodeficiency viruses, Antimicr ób. Agents Chemother. 34:1505 (1990).

    Article  CAS  Google Scholar 

  20. R. C. Cronn, J.D. Whitmer and T.W. North, Rnase H activity associated with reverse transcriptase from feline immunodeficiency virus, J. Virol. 66:1215 (1992).

    PubMed  CAS  Google Scholar 

  21. K. M. Remington, B. Chesebro, K. Wehrly, N.C. Pedersen and T.W. North, Mutants of feline immunodeficiency virus resistant to 3’-azido-3’-deoxythymidine, J. Virol. 65:308 (1991).

    PubMed  CAS  Google Scholar 

  22. F. Tozzini, D. Matteucci, P. Bandecchi, F. Baldinotti, K.H.J. Siebelink, A. Osterhaus and M. Bendinelli, Neutralizing antibodies in feline immunodeficiency virus infected cats, submitted.

    Google Scholar 

  23. T. Miyazawa, M. Fukasawa, A. Hasegawa, N. Maki, K. Ikuta, E. Takahashi, M. Hayami and T. Mikami, Molecular cloning of a novel isolate of feline immunodeficiency virus biologically and genetically different from the original U.S. isolate, J. Virol. 65:1572 (1991).

    PubMed  CAS  Google Scholar 

  24. K. H. J. Siebelink, I. Chu, G.F. Rimmelzwaan, K. Weijer, A.D.M.E. Osterhaus and M. L. Bosch, Isolation and partial characterization of infectious molecular clones of feline immunodeficiency virus obtained directly from bone marrow DNA of a naturally infected cat, J. Virol. 66:1091 (1992).

    PubMed  CAS  Google Scholar 

  25. T. R. Phillips, R.L. Talbott, C. Lamont, S. Muir, K. Lovelace and J.H. Elder, Comparison of two host cell range variants of feline immunodeficiency virus, J. Virol. 64:4605 (1990).

    PubMed  CAS  Google Scholar 

  26. S. Morikawa, H. Lutz, A. Aubert and D.H.L. Bishop, Identification of conserved and variable regions in the envelope glycoprotein sequences of two feline immunodeficiency viruses isolated in Zurich, Switzerland, Virus Res. 21:53 (1991).

    Article  PubMed  CAS  Google Scholar 

  27. M. Riçby, N. Macckay, J. Neil, E. Holmes, M. Pistello and M. Bosch, Sequence variation in FIV env: Evidence of distinct geographical clusters of isolates and of selection for change at variable regions, Proc. Workshop Eur. Commission Concerted Action on Feline AIDS, Lucca 18–21 June 1992, p. 9.

    Google Scholar 

  28. P. Nara, R.R. Garrity and J. Gousmit, Neutralization of HIV-1: A paradox of humoral proportions, FASEB. J. 5:2437 (1991).

    PubMed  CAS  Google Scholar 

  29. F. Esposito, C. La Rosa, A. Habluetzel, S. Lombardi, C. Garzelli, D. Matteucci, and M. Bendinelli, Mapping of linear B epitopes on the V3 region of feline immunodeficiency virus surface glycoprotein, Proc. Workshop Eur. Commission Concerted Action on Feline AIDS, Lucca 18–21 June 1992, p. 14.

    Google Scholar 

  30. C. Locardi, P. Puddu, M. Ferrantini, E. Parlanti, P. Sestili, F. Varano and F. Belardelli, Persistent infection of normal mice with human immunodeficiency virus, J. Virol. 66:1649 (1992).

    PubMed  CAS  Google Scholar 

  31. H. F. Egberink and M.C Horzinek, Phenotypic mixing leads to broadening of cell spectrum of feline immunodeficiency virus, Proc. 1st Inter. Conf. F1V Res. ,Davis 4–7 September, 1991, p. 20.

    Google Scholar 

  32. Y. Kawaguchi, T. Miyazawa, T. Horimoto, S.-I. Itagaki, M. Fukasawa, E. Takahashi and T. Mikami, Activation of feline immunodeficiency virus long terminal repeat by feline herpesvirus type 1, Virol. 184:449 (1991).

    Article  CAS  Google Scholar 

  33. M. J. Hosie, G. Reid, J.C. Neil and O. Jarrett, Enhancement of FIV infection after vaccination, Proc. 1st Inter. Conf. FIV Res. ,Davis 4–7 September, 1991, p. 64.

    Google Scholar 

  34. J. K. Yamamoto, T. Okuda, C.D. Ackley, H. Zochlinski, E. Penbroke, and M.B. Gardner, Experimental vaccine protection against FIV, Proc. 1st Inter. Conf. FIV Res. ,Davis 4–7 September, 1991, p. 63.

    Google Scholar 

  35. J. K. Yamamoto, T. Okuda, C.D. Ackley, H. Louie, E. Penbroke, H. Zochlinski, R.J. Munn and M.B. Gardner, Experimental vaccine protection against feline immunodeficiency virus, AIDS Res. Hum. Retrov. 7:911 (1991).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dipartimento di Biomedicina e, Università di Camerino, Italy

    M. Bendinelli, M. Pistello, D. Matteucci, S. Lombardi, F. Baldinotti, R. Ghilarducci, L. Ceccherini-Nelli, C. Garzelli & G. Malvaldi

  2. Dipartimento di Patologia Animale, Università di Pisa e, Italy

    P. Bandecchi, A. Poli & F. Tozzini

  3. Dipartimento di Biologia Cellulare e Molecolare, Università di Camerino, Italy

    F. Esposito

Authors
  1. M. Bendinelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Pistello
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. Matteucci
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Lombardi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. F. Baldinotti
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. P. Bandecchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. R. Ghilarducci
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. L. Ceccherini-Nelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. C. Garzelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. A. Poli
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. F. Esposito
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. G. Malvaldi
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. F. Tozzini
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of South Florida, Tampa, Florida, USA

    Herman Friedman , Thomas W. Klein  & Steven Specter ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer Science+Business Media New York

About this chapter

Cite this chapter

Bendinelli, M. et al. (1993). Small Animal Model of AIDS and the Feline Immunodeficiency Virus. In: Friedman, H., Klein, T.W., Specter, S. (eds) Drugs of Abuse, Immunity, and AIDS. Advances in Experimental Medicine and Biology, vol 335. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2980-4_27

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-2980-4_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6297-5

  • Online ISBN: 978-1-4615-2980-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation