Abstract
It has been suggested1 that in order to inactivate a cell, the nucleus must receive one or more direct hits from a heavy charged particle. This principle could be extended to the a particles and the 7Li recoil ions produced in the 10B(n,α)7Li reaction, which is central to the principle of boron neutron capture therapy (BNCT). As a result, the microdistribution of a boron compound in tissue can drastically change the dose needed to inactivate malignant cells. Therefore, being able to determine microscopically the effect of different boron compounds through their microdistributions is clearly of major importance to BNCT. Previous microdosimetric analyses of the 10B(n,α)7Li reaction have been accomplished by assuming mathematical models of cells and calculating the absorbed doses due to the α particle and 7Li recoil ion based on assumed boron microdistribution 2–7
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© 1993 Springer Science+Business Media New York
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Solares, G.R., Zamenhof, R.G., Cano, G. (1993). Microdosimetry and Compound Factors for Neutron Capture Therapy. In: Soloway, A.H., Barth, R.F., Carpenter, D.E. (eds) Advances in Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2978-1_42
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DOI: https://doi.org/10.1007/978-1-4615-2978-1_42
Publisher Name: Springer, Boston, MA
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